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View Structure Prediction Details

Protein: POT1
Organism: Saccharomyces cerevisiae
Length: 417 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for POT1.

Description E-value Query
Range
Subject
Range
gi|3309206 - gi|3309206|gb|AAC26026.1| thiolase B [Clostridium acetobutylicum]
gi|14994394, gi|... - gi|3309206|gb|AAC26026.1| thiolase B [Clostridium acetobutylicum], gi|15004782|ref|NP_149242.1| acet...
0.0 [33..417] [1..392]
gi|13622708, gi|... - gi|15675510|ref|NP_269684.1| putative acetyl-CoA:acetyltransferase [Streptococcus pyogenes M1 GAS], ...
gi|71853939, gi|... - gi|71911157|ref|YP_282707.1| acetyl-CoA acetyltransferase [Streptococcus pyogenes MGAS5005], gi|7185...
0.0 [33..414] [1..391]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [33..416] [1..392]
gi|19746559, gi|... - gi|19748772|gb|AAL98194.1| putative acetyl-CoA:acetyltransferase [Streptococcus pyogenes MGAS8232], ...
0.0 [33..414] [1..391]
THLA_STAAM - Probable acetyl-CoA acyltransferase OS=Staphylococcus aureus (strain Mu50 / ATCC 700699) GN=SAV0354 ...
THLA_STAAN - Probable acetyl-CoA acyltransferase OS=Staphylococcus aureus (strain N315) GN=SA0342 PE=1 SV=1
gi|156720817, gi... - gi|156978682|ref|YP_001440941.1| acetyl-CoA C-acetyltransferase homologue [Staphylococcus aureus sub...
gi|25286405 - pir||C89801 hypothetical protein SA0342 [imported] - Staphylococcus aureus (strain N315)
gi|253316545 - gi|253316545|ref|ZP_04839758.1| hypothetical protein SauraC_10450 [Staphylococcus aureus subsp. aure...
gi|255005149 - gi|255005149|ref|ZP_05143750.2| hypothetical protein SauraM_01740 [Staphylococcus aureus subsp. aure...
0.0 [33..416] [1..391]
gi|170711812, gi... - gi|170711812|gb|EDT23994.1| acetyl-CoA acetyltransferase [Clostridium perfringens B str. ATCC 3626],...
gi|110799474, gi... - gi|110799474|ref|YP_696874.1| acetyl-CoA acetyltransferase [Clostridium perfringens ATCC 13124], gi|...
gi|168213701, gi... - gi|170714774|gb|EDT26956.1| acetyl-CoA acetyltransferase [Clostridium perfringens CPE str. F4969], g...
gi|18145860, gi|... - gi|18311177|ref|NP_563111.1| acetyl-CoA acetyltransferase [Clostridium perfringens str. 13], gi|1814...
0.0 [33..416] [1..392]
gi|145013|gb|AAA... - 3-hydroxybutyric acid
THIL_CHRVI - Acetyl-CoA acetyltransferase OS=Chromatium vinosum GN=phbA PE=3 SV=1
0.0 [34..416] [3..393]
THIK_YEAST - 3-ketoacyl-CoA thiolase, peroxisomal OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=POT...
POT1 - 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA an...
gi|207344449 - gi|207344449|gb|EDZ71592.1| YIL160Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|151943006 - gi|151943006|gb|EDN61341.1| 3-oxoacyl CoA thiolase [Saccharomyces cerevisiae YJM789]
gi|190406372 - gi|190406372|gb|EDV09639.1| 3-oxoacyl CoA thiolase [Saccharomyces cerevisiae RM11-1a]
0.0 [1..417] [1..417]

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Predicted Domain #1
Region A:
Residues: [1-417]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQRLQSIKD HLVESAMGKG ESKRKNSLLE KRPEDVVIVA ANRSAIGKGF KGAFKDVNTD  60
   61 YLLYNFLNEF IGRFPEPLRA DLNLIEEVAC GNVLNVGAGA TEHRAACLAS GIPYSTPFVA 120
  121 LNRQCSSGLT AVNDIANKIK VGQIDIGLAL GVESMTNNYK NVNPLGMISS EELQKNREAK 180
  181 KCLIPMGITN ENVAANFKIS RKDQDEFAAN SYQKAYKAKN EGLFEDEILP IKLPDGSICQ 240
  241 SDEGPRPNVT AESLSSIRPA FIKDRGTTTA GNASQVSDGV AGVLLARRSV ANQLNLPVLG 300
  301 RYIDFQTVGV PPEIMGVGPA YAIPKVLEAT GLQVQDIDIF EINEAFAAQA LYCIHKLGID 360
  361 LNKVNPRGGA IALGHPLGCT GARQVATILR ELKKDQIGVV SMCIGTGMGA AAIFIKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10122.0
Match: 1afwA_
Description: Thiolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
acetyl-CoA C-acyltransferase activity 8.08119341370748 bayes_pls_golite062009
long-chain-3-hydroxyacyl-CoA dehydrogenase activity 7.45371477074071 bayes_pls_golite062009
long-chain-enoyl-CoA hydratase activity 5.63866392580915 bayes_pls_golite062009
transferase activity, transferring acyl groups 4.96408928512745 bayes_pls_golite062009
fatty acid synthase activity 3.79121338118181 bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] synthase activity 3.71249191203055 bayes_pls_golite062009
C-acyltransferase activity 3.27532895419051 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.14957464437124 bayes_pls_golite062009
acyltransferase activity 3.06879684191353 bayes_pls_golite062009
transferase activity 2.15834234036431 bayes_pls_golite062009
catalytic activity 2.14505178497871 bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity 1.87304265492939 bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 1.77798276950874 bayes_pls_golite062009
acetyl-CoA C-acetyltransferase activity 1.50839304016514 bayes_pls_golite062009
C-acetyltransferase activity 1.19264084089277 bayes_pls_golite062009
hydroxymethylglutaryl-CoA synthase activity 1.16785899347652 bayes_pls_golite062009
acetyltransferase activity 0.6519546920419 bayes_pls_golite062009
binding 0.415385255550741 bayes_pls_golite062009
enoyl-CoA hydratase activity 0.21899828831708 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle