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View Structure Prediction Details

Protein: MET18
Organism: Saccharomyces cerevisiae
Length: 1032 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MET18.

Description E-value Query
Range
Subject
Range
MMS19_MOUSE - MMS19 nucleotide excision repair protein homolog OS=Mus musculus GN=Mms19 PE=1 SV=1
0.0 [23..1027] [28..1027]
MET18 - DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymeras...
MET18_YEAST - DNA repair/transcription protein MET18/MMS19 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c...
0.0 [1..1032] [1..1032]
MMS19 - MMS19 nucleotide excision repair homolog (S. cerevisiae)
0.0 [23..1027] [27..1026]
MMS19_SCHPO - DNA repair/transcription protein mms19 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mms...
SPAC1071.02 - TFIIH regulator
0.0 [7..1024] [3..1017]

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Predicted Domain #1
Region A:
Residues: [1-207]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTPDELNSAV VTFMANLNID DSKANETAST VTDSIVHRSI KLLEVVVALK DYFLSENEVE  60
   61 RKKALTCLTT ILAKTPKDHL SKNECSVIFQ FYQSKLDDQA LAKEVLEGFA ALAPMKYVSI 120
  121 NEIAQLLRLL LDNYQQGQHL ASTRLWPFKI LRKIFDRFFV NGSSTEQVKR INDLFIETFL 180
  181 HVANGEKDPR NLLLSFALNK SITSSLQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [208-458]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVENFKEDLF DVLFCYFPIT FKPPKHDPYK ISNQDLKTAL RSAITATPLF AEDAYSNLLD  60
   61 KLTASSPVVK NDTLLTLLEC VRKFGGSSIL ENWTLLWNAL KFEIMQNSEG NENTLLNPYN 120
  121 KDQQSDDVGQ YTNYDACLKI INLMALQLYN FDKVSFEKFF THVLDELKPN FKYEKDLKQT 180
  181 CQILSAIGSG NVEIFNKVIS STFPLFLINT SEVAKLKLLI MNFSFFVDSY IDLFGRTSKE 240
  241 SLGTPVPNNK M

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [459-849]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEYKDEIIMI LSMALTRSSK AEVTIRTLSV IQFTKMIKMK GFLTPEEVSL IIQYFTEEIL  60
   61 TDNNKNIYYA CLEGLKTISE IYEDLVFEIS LKKLLDLLPD CFEEKIRVND EENIHIETIL 120
  121 KIILDFTTSR HILVKESITF LATKLNRVAK ISKSREYCFL LISTIYSLFN NNNQNENVLN 180
  181 EEDALALKNA IEPKLFEIIT QESAIVSDNY NLTLLSNVLF FTNLKIPQAA HQEELDRYNE 240
  241 LFISEGKIRI LDTPNVLAIS YAKILSALNK NCQFPQKFTV LFGTVQLLKK HAPRMTETEK 300
  301 LGYLELLLVL SNKFVSEKDV IGLFDWKDLS VINLEVMVWL TKGLIMQNSL ESSEIAKKFI 360
  361 DLLSNEEIGS LVSKLFEVFV MDISSLKKFK G

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.96084803796407 bayes_pls_golite062009
nucleic acid binding 2.2915564382469 bayes_pls_golite062009
transcription regulator activity 2.19067997822967 bayes_pls_golite062009
DNA binding 1.71679738414596 bayes_pls_golite062009
protein binding 1.61131270705552 bayes_pls_golite062009
transcription factor activity 1.01026749293758 bayes_pls_golite062009
structural molecule activity 0.851103372489505 bayes_pls_golite062009
structure-specific DNA binding 0.384349606267362 bayes_pls_golite062009
translation regulator activity 0.378889783888265 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.348192604482187 bayes_pls_golite062009
RNA binding 0.243875756041061 bayes_pls_golite062009
transcription activator activity 0.142253868848261 bayes_pls_golite062009
transcription factor binding 8.79739237675814E-4 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [850-1032]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISWNNNVKIL YKQKFFGDIF QTLVSNYKNT VDMTIKCNYL TALSLVLKHT PSQSVGPFIN  60
   61 DLFPLLLQAL DMPDPEVRVS ALETLKDTTD KHHTLITEHV STIVPLLLSL SLPHKYNSVS 120
  121 VRLIALQLLE MITTVVPLNY CLSYQDDVLS ALIPVLSDKK RIIRKQCVDT RQVYYELGQI 180
  181 PFE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle