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View Structure Prediction Details

Protein: HOS4
Organism: Saccharomyces cerevisiae
Length: 1083 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HOS4.

Description E-value Query
Range
Subject
Range
HOS4 - Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes tha...
HOS4_YEAST - Protein HOS4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOS4 PE=1 SV=1
0.0 [1..1083] [1..1083]
ANK2 - ankyrin 2, neuronal
0.0 [87..928] [2..811]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [93..928] [18..813]
gi|3885972 - gi|3885972|gb|AAC78143.1| 270 kDa ankyrin G isoform [Rattus norvegicus]
0.0 [93..928] [18..821]

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Predicted Domain #1
Region A:
Residues: [1-202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNETTTKQPL KKRSLSSYLS NVSTRREELE KISKQETSEE EDTAGKHEQR ETLSEEVSDK  60
   61 FPENVASFRS QTTSVHQATQ NNLNAKESED LAHKNDASSH EGEVNGDSRP DDVPETNEKI 120
  121 SQAIRAKISS SSSSPNVRNV DIQNHQPFSR DQLRAMLKEP KRKTVDDFIE EEGLGAVEEE 180
  181 DLSDEVLEKN TTEPENVEKD IE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [203-301]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSDSDKDTDD VGSDDPTAPN SPIKLGRRKL VRGDQLDATT SSMFNNESDS ELSDIDDSKN  60
   61 IALSSSLFRG GSSPVKETNN NLSNMNSSPA QNPKRGSVS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 73.67837
Match: 1ihbA_
Description: p18ink4C(ink6)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [302-388]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSNDSNKSSH IAVSKRPKQK KGIYRDSGGR TRLQIACDKG KYDVVKKMIE EGGYDINDQD  60
   61 NAGNTALHEA ALQGHIEIVE LLIENGA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 73.67837
Match: 1ihbA_
Description: p18ink4C(ink6)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.60916417202222 bayes_pls_golite062009
protein binding 1.64872738860757 bayes_pls_golite062009
cytoskeletal protein binding 1.39841714205637 bayes_pls_golite062009
structural constituent of cytoskeleton 0.89889442280136 bayes_pls_golite062009
transcription factor binding 0.84590123339816 bayes_pls_golite062009
structural molecule activity 0.808967137205604 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 0.68541709976608 bayes_pls_golite062009
transcription regulator activity 0.589753112911856 bayes_pls_golite062009
protein kinase regulator activity 0.576422771673579 bayes_pls_golite062009
histone methyltransferase activity 0.457348070377128 bayes_pls_golite062009
kinase regulator activity 0.4228431685549 bayes_pls_golite062009
protein kinase activity 0.348635473808088 bayes_pls_golite062009
nucleic acid binding 0.280340492381105 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.144979134227429 bayes_pls_golite062009
DNA binding 0.139886855398905 bayes_pls_golite062009
transcription repressor activity 0.108244697820437 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0107560517063403 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [389-481]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVNIKSIEMF GDTPLIDASA NGHLDVVKYL LKNGADPTIR NAKGLTAFES VDDESEFDDE  60
   61 EDQKILREIK KRLSIAAKKW TNRAGIHNDK SKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 111.9897
Match: 1awcB_
Description: GA bindinig protein (GABP) beta 1
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [482-557]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNNAHTIDQP PFDNTTKAKN EKAADSPSMA SNIDEKAPEE EFYWTDVTSR AGKEKLFKAS  60
   61 KEGHLPYVGT YVENGG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [558-625]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIDLRSFFES VKCGHEDITS IFLAFGFPVN QTSRDNKTSA LMVAVGRGHL GTVKLLLEAG  60
   61 ADPTKRDK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 134.29073
Match: 1myo__
Description: Myotrophin
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [626-678]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGRTALYYAK NSIMGITNSE EIQLIENAIN NYLKKHSEDN NDDDDDDDNN NET

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 134.29073
Match: 1myo__
Description: Myotrophin
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [679-939]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKHEKKREKT QSPILASRRS ATPRIEDEED DTRMLNLADD DFNNDRDVKE STTSDSRKRL  60
   61 DDNENVGTQY SLDWKKRKTN ALQDEEKLKS ISPLSMEPHS PKKAKSVEIS KIHEETAAER 120
  121 EARLKEEEEY RKKRLEKKRK KEQELLQKLA EDEKKRIEEQ EKQKVLEMER LEKATLEKAR 180
  181 KMEREKEMEE ISYRRAVRDL YPLGLKIINF NDKLDYKRFL PLYYFVDEKN DKFVLDLQVM 240
  241 ILLKDIDLLS KDNQPTSEKI P

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 11.83
Match: 1ldvA
Description: No description for 1ldvA was found.

Predicted Domain #9
Region A:
Residues: [940-1083]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDPSHLTPLW NMLKFIFLYG GSYDDKKNNM ENKRYVVNFD GVDLDTKIGY ELLEYKKFVS  60
   61 LPMAWIKWDN VVIENHAKRK EIEGNMIQIS INEFARWRND KLNKAQQPTR KQRSLKIPRE 120
  121 LPVKFQHRMS ISSVLQQTSK EPFW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle