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View Structure Prediction Details

Protein: SKN7
Organism: Saccharomyces cerevisiae
Length: 622 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SKN7.

Description E-value Query
Range
Subject
Range
SKN7 - Nuclear response regulator and transcription factor, part of a branched two-component signaling syst...
SKN7_YEAST - Transcription factor SKN7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SKN7 PE=1 SV=1
gi|151944151 - gi|151944151|gb|EDN62444.1| suppressor of kre null [Saccharomyces cerevisiae YJM789]
0.0 [1..622] [1..622]
HSF1_CHICK - Heat shock factor protein 1 OS=Gallus gallus GN=HSF1 PE=2 SV=1
1.0E-89 [65..434] [1..395]
gi|10175779, gi|... - gi|15615719|ref|NP_244023.1| two-component response regulator involved in phosphate regulation [Baci...
gi|25300880 - pir||E84044 two-component response regulator involved in phosphate regulation phoP [imported] - Baci...
4.0E-88 [375..611] [1..239]
HSF1 - heat shock transcription factor 1
gi|61362382, gi|... - gi|61362386|gb|AAX42211.1| heat shock transcription factor 1 [synthetic construct], gi|61362382|gb|A...
3.0E-87 [73..374] [4..293]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
3.0E-87 [73..374] [4..293]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-86 [378..608] [5..234]
gi|25301054 - pir||AG1955 two-component response regulator alr1194 [imported] - Nostoc sp. (strain PCC 7120)
gi|17130541, gi|... - gi|17228689|ref|NP_485237.1| two-component response regulator [Nostoc sp. PCC 7120], gi|17130541|dbj...
1.0E-86 [375..607] [1..225]
gi|25300922 - pir||G97109 response regulator (CheY-like receiver domain and DNA-binding HTH domain) [imported] - C...
gi|15894977, gi|... - gi|15894977|ref|NP_348326.1| response regulator [Clostridium acetobutylicum ATCC 824], gi|15024664|g...
3.0E-86 [378..604] [5..227]
gi|4982229, gi|1... - gi|4982229|gb|AAD36722.1|AE001807_13 response regulator DrrA [Thermotoga maritima MSB8], gi|15644403...
gi|7444020 - pir||D72228 response regulator DrrA - Thermotoga maritima (strain MSB8)
4.0E-86 [377..607] [12..243]
gi|1575577 - gi|1575577|gb|AAC44436.1| DNA-binding response regulator [Thermotoga maritima]
8.0E-86 [377..607] [4..235]

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Predicted Domain #1
Region A:
Residues: [1-67]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFSTINSNV NKTTGDSNNN TTENSSTADL LGMDLLQSGP RLMNTMQPNN SSDMLHINNK  60
   61 TNNVQQP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.461 a.65.1 Annexin
View Download 0.605 d.95.2 Homing endonucleases
View Download 0.425 d.74.2 C-terminal domain of arginine repressor
View Download 0.494 d.230.3 Amyloid beta a4 protein copper binding domain (domain 2)
View Download 0.466 d.47.1 Ribosomal protein L11, N-terminal domain
View Download 0.413 d.58.17 Metal-binding domain
View Download 0.404 a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.401 a.4.5 "Winged helix" DNA-binding domain
View Download 0.399 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.370 d.68.7 R3H domain
View Download 0.355 d.15.7 Immunoglobulin-binding domains
View Download 0.350 d.68.3 SirA-like
View Download 0.336 d.88.1 SRF-like
View Download 0.336 a.4.5 "Winged helix" DNA-binding domain
View Download 0.323 d.76.1 GYF domain
View Download 0.322 d.68.5 C-terminal domain of ProRS
View Download 0.321 d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.316 d.58.17 Metal-binding domain
View Download 0.306 d.58.7 RNA-binding domain, RBD
View Download 0.301 a.28.1 ACP-like
View Download 0.299 d.26.3 Chitinase insertion domain
View Download 0.293 d.15.8 Translation initiation factor IF3, N-terminal domain
View Download 0.286 a.144.1 PABC (PABP) domain
View Download 0.285 a.6.1 Putative DNA-binding domain
View Download 0.266 a.4.5 "Winged helix" DNA-binding domain
View Download 0.263 d.39.1 Dynein light chain 8 (DLC8)
View Download 0.261 d.58.42 N-utilization substance G protein NusG, N-terminal domain
View Download 0.261 d.95.2 Homing endonucleases
View Download 0.258 a.60.2 RuvA domain 2-like
View Download 0.255 a.2.3 Chaperone J-domain
View Download 0.232 d.58.7 RNA-binding domain, RBD
View Download 0.212 d.201.1 SRP19

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 4.84466441605416 bayes_pls_golite062009
nucleic acid binding 4.57954522145536 bayes_pls_golite062009
transcription factor activity 4.12685284895733 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
sequence-specific DNA binding 2.3918869755162 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.70025468248325 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
two-component response regulator activity 0.290986349914258 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [68-201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGNTNISSAN AGAKAPANEF VRKLFRILEN NEYPDIVTWT ENGKSFVVLD TGKFTTHILP  60
   61 NHFKHSNFAS FVRQLNKYDF HKVKRSPEER QRCKYGEQSW EFQHPEFRVH YGKGLDNIKR 120
  121 KIPAQRKVLL DESQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 200.9897
Match: 1hks__
Description: Heat-shock transcription factor
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [202-369]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KALLHFNSEG TNPNNPSGSL LNESTTELLL SNTVSKDAFG NLRRRVDKLQ KELDMSKMES  60
   61 YATKVELQKL NSKYNTVIES LITFKTINEN LLNNFNTLCS TLANNGIEVP IFGDNGNRNP 120
  121 TGNTNPATTT AIQSNNNTNN ASPATSTVSL QLPNLPDQNS LTPNAQNN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [370-500]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVTLRKGFHV LLVEDDAVSI QLCSKFLRKY GCTVQVVSDG LSAISTLEKY RYDLVLMDIV  60
   61 MPNLDGATAT SIVRSFDNET PIIAMTGNIM NQDLITYLQH GMNDILAKPF TRDDLHSILI 120
  121 RYLKDRIPLC E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 122.232149
Match: 1kgsA_
Description: PhoB; PhoB receiver domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [501-622]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQLPPRNSSP QTHSNTNTAN SNPNTINEQS LAMLPQDNPS TTTPVTPGAS ISSAQHVQQG  60
   61 QQEQQHQIFH AQQQQQHHNA IANARSDVAI PNLEHEINTV PHSSMGSTPQ LPQSTLQENQ 120
  121 LS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 122.232149
Match: 1kgsA_
Description: PhoB; PhoB receiver domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle