YRC Public Data Repository - Protein Structure Prediction

Protein:	BZZ1
Organism:	Saccharomyces cerevisiae
Length:	633 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BZZ1.

Description	E-value	Query Range	Subject Range
gi\|45270106 - gi\|45270106\|gb\|AAS56434.1\| YHR114W [Saccharomyces cerevisiae]	368.0	[0..1]	[633..1]
gi\|68388302 - gi\|68388302\|ref\|XP_696268.1\| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]	309.0	[0..2]	[529..2099]
SPBC12C2.05c - diacylglycerol binding protein Bzz1 BZZ1_SCHPO - Protein BZZ1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=bzz1 PE=3 SV=1	298.0	[0..7]	[632..8]
gi\|50757613 - gi\|50757613\|ref\|XP_415578.1\| PREDICTED: similar to myosin heavy chain [Gallus gallus]	282.0	[0..2]	[529..1046]
gi\|49526680, gi\|... - gi\|50289877\|ref\|XP_447370.1\| hypothetical protein CAGL0I02750g [Candida glabrata CBS138], gi\|4952668... gi\|49526680 - gi\|49526680\|emb\|CAG60307.1\| unnamed protein product [Candida glabrata]	268.0	[0..4]	[632..2]
gi\|109462528 - gi\|109462528\|ref\|XP_001067481.1\| PREDICTED: similar to FCH and double SH3 domains 2 [Rattus norvegic...	266.0	[0..18]	[629..567]
gi\|109107707 - gi\|109107707\|ref\|XP_001110150.1\| PREDICTED: similar to FCH and double SH3 domains 2 [Macaca mulatta]	264.0	[0..33]	[629..244]
gi\|14250231, gi\|... - ref\|NP_659210.1\| myosin, heavy polypeptide 2, skeletal muscle, adult [Mus musculus], gi\|14250231\|gb...	260.0	[0..2]	[484..1102]

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Predicted Domain #1

Region A:
Residues: [1-420]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSADLSIGNE IKDSFKETHK WVQNNLKWLK DIEQFYRERA KLEKDYSERL SRLSAEYFNK  60
   61 KSSTSVPISV GDTPTTTPGS IEAAGVVAWN EILSQTDMIS KDHDQLSTDF ENHVANQLSG 120
  121 LFTKLDMTLS KINGFNNDMV NKKDNIYHEL EKAKKDYDEA CSTMEMARNR YTKASNDRNK 180
  181 KKLDEKEMEM NKCKNEYLIK INQANRTKDK YYFQDVPEVL DLLQDVNEAK TLFLNDLWLK 240
  241 AASVENDLGA NVSKRLQAAN SVVKQNKPSL NTAIFIKHNL KNWKEPQDFV YKPSPVWHDD 300
  301 EKFAVPSSLE VEDLRIKLAK AENDYNSLQD KTQNELSKLS TLNKIKHEMK TNEDNINATK 360
  361 FYDTLKEYLN VVSPFTSHET LKLQAEVQIE SIQNNVPEEY DLSTDNIDLS KTKKKSGIFS 420
  421

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	12.69897
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [421-495]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFKHNILNVD SKPSSGGSTG NGNGGPLHIT SLFNTSRRTR LGSAPNNAGE DSDNNSIRTT  60
   61 STNNTKKTTQ NSSDD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [496-565]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKNKVLYAYV QKDDDEITIT PGDKISLVAR DTGSGWTKIN NDTTGETGLV PTTYIRISSA  60
   61 ATVKANDRGP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	3.154902
Match:	1pnjA
Description:	SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [566-633]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APEVPPPRRS TLPVRTMEAI YAYEAQGDDE ISIDPGDIIT VIRGDDGSGW TYGECDGLKG  60
   61 LFPTSYCK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	36.917458
Match:	1gcqA
Description:	Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits