YRC Public Data Repository - Protein Structure Prediction

Protein:	YHR112C
Organism:	Saccharomyces cerevisiae
Length:	378 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YHR112C.

Description	E-value	Query Range	Subject Range
gi\|13699175, gi\|... - gi\|51261011\|gb\|AAH78869.1\| Cystathionase (cystathionine gamma-lyase) [Rattus norvegicus], gi\|1403106...	0.0	[4..374]	[17..396]
CGL_MOUSE - Cystathionine gamma-lyase OS=Mus musculus GN=Cth PE=1 SV=1	0.0	[4..374]	[17..396]
MEGL_FUSNN - L-methionine gamma-lyase OS=Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130...	0.0	[3..374]	[7..395]
METB_HELPY - Cystathionine gamma-synthase OS=Helicobacter pylori (strain ATCC 700392 / 26695) GN=metB PE=1 SV=1 METB_HELPY - Cystathionine gamma-synthase OS=Helicobacter pylori GN=metB PE=3 SV=1	0.0	[2..374]	[1..379]
gi\|15023241, gi\|... - gi\|15893681\|ref\|NP_347030.1\| cystathionine gamma-synthase [Clostridium acetobutylicum ATCC 824], gi\|... gi\|25292095 - pir\|\|G96947 cystathionine gamma-synthase [imported] - Clostridium acetobutylicum	0.0	[3..373]	[8..384]
gi\|9929259 - gi\|9929259\|emb\|CAC05298.1\| cystathionine beta-lyase [Lactobacillus reuteri]	2.0E-99	[2..374]	[1..379]
MCCB_BACSU - Cystathionine gamma-lyase OS=Bacillus subtilis GN=mccB PE=1 SV=1 gi\|221324186 - gi\|221324186\|ref\|ZP_03605480.1\| cystathionine beta-lyase [Bacillus subtilis subsp. subtilis str. SMY... gi\|221319905 - gi\|221319905\|ref\|ZP_03601199.1\| cystathionine beta-lyase [Bacillus subtilis subsp. subtilis str. JH6... gi\|221314984 - gi\|221314984\|ref\|ZP_03596789.1\| cystathionine beta-lyase [Bacillus subtilis subsp. subtilis str. NCI... MCCB_BACSU - Cystathionine gamma-lyase OS=Bacillus subtilis (strain 168) GN=mccB PE=1 SV=1	2.0E-98	[2..374]	[1..379]
gi\|5104901, gi\|1... - gi\|5104901\|dbj\|BAA80215.1\| cystathionine gamma-lyase [Aeropyrum pernix K1], gi\|14601268\|ref\|NP_14780... gi\|7437088 - pir\|\|A72595 probable cystathionine gamma-lyase APE1226 - Aeropyrum pernix (strain K1)	5.0E-98	[1..373]	[1..383]

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Predicted Domain #1

Region A:
Residues: [1-252]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDLSTALIH GDDKDNRVTD VAPPINVSTT FRYDDDDLIP WTERENLDFM EKKPVYSRLA  60
   61 HPNSTRLESI FSEILDGYAV IYSSGLAAFY AAMVHYNPKK IFIGQSYHGV RAIANILTRN 120
  121 YGIEQHPLED IEKCASEGDI VHLESPVNPY GTSSDIESLA RRAHAKGALL IVDSTFASPP 180
  181 LQYAWNFGAD IVLYSATKYF GGHSDLLSGV LVVKEEATSR QLKDDRIYLG TNVANLESFM 240
  241 LLRSLRTYEM RI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [290-299]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVKKQLVGGY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	452.0
Match:	1ibjA_
Description:	Cystathionine beta-lyase, CBL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	2.82824364293374	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	2.82824364293374	bayes_pls_golite062009
catalytic activity	2.29878871754893	bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity	1.87460342369605	bayes_pls_golite062009
transcription regulator activity	1.67701710033155	bayes_pls_golite062009
DNA binding	1.4774443071095	bayes_pls_golite062009
transferase activity	1.44093490824786	bayes_pls_golite062009
nucleic acid binding	1.39741122443159	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
transcription factor activity	1.15775909410582	bayes_pls_golite062009
binding	1.09053123792737	bayes_pls_golite062009
O-phospho-L-serine:2-oxoglutarate aminotransferase activity	0.994935084630764	bayes_pls_golite062009
ligase activity	0.827063849687833	bayes_pls_golite062009
carbon-sulfur lyase activity	0.698312655247044	bayes_pls_golite062009
cystathionine beta-lyase activity	0.6849039330512	bayes_pls_golite062009
vitamin binding	0.66463470119531	bayes_pls_golite062009
cystathionine gamma-lyase activity	0.505859361763689	bayes_pls_golite062009
alanine-glyoxylate transaminase activity	0.48682493494502	bayes_pls_golite062009
O-acyltransferase activity	0.452440867878365	bayes_pls_golite062009
cysteine synthase activity	0.417849187928985	bayes_pls_golite062009
structural molecule activity	0.347975812448725	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	0.271623203801431	bayes_pls_golite062009
pyridoxal phosphate binding	0.16957228630576	bayes_pls_golite062009
vitamin B6 binding	0.16957228630576	bayes_pls_golite062009
adenosylmethionine-8-amino-7-oxononanoate transaminase activity	0.0669652799570574	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [253-289]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKQSENATKL VRFLSDHQSE FDKVLKTIYH SSLQTEE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [300-378]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPVFAITLYT KEQCKQLPLK LKYFHHATSL GGIESLVEWR AMTDPYIDQT LIRVSVGCES  60
   61 ANDLIKDLAS ALKELQDAA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	452.0
Match:	1ibjA_
Description:	Cystathionine beta-lyase, CBL
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: