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View Structure Prediction Details

Protein: ETP1
Organism: Saccharomyces cerevisiae
Length: 585 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ETP1.

Description E-value Query
Range
Subject
Range
ETP1_YEAST - RING finger protein ETP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ETP1 PE=1 SV=1
ETP1 - Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger ...
0.0 [1..563] [1..563]
gi|3252872 - gi|3252872|gb|AAC24200.1| BRCA1-associated protein 2 [Homo sapiens]
3.0E-90 [7..548] [59..547]
BRAP_MOUSE - BRCA1-associated protein OS=Mus musculus GN=Brap PE=1 SV=1
5.0E-84 [7..582] [59..591]
pink-1 - status:Partially_confirmed UniProt:Q09298 protein_id:AAK93845.1
8.0E-71 [11..577] [726..1238]
EPT1_SCHPO - RING finger protein ETP1 homolog OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC16E8....
SPAC16E8.13 - ubiquitin-protein ligase E3
5.0E-61 [70..569] [48..522]
gi|3668187 - gi|3668187|dbj|BAA33452.1| myosin heavy chain [Theragra chalcogramma]
1.0E-46 [339..584] [821..1086]

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Predicted Domain #1
Region A:
Residues: [1-209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQFEYIITL EFGNQNQVES AYQIFKSIPK KLKAKSIGEE SIKSNNQDWQ DWRVCDLEID  60
   61 MITDFKNQTS KEEESDLITS QYLGHGIIRL FKLSNANNTL NEKEILTIPG DDTMICILFV 120
  121 PTYFTVHDLL HFYIGDDIVN KQVSNFRILR NQQKGMGFNF TVLIKFRNAL DAKNFKEEFN 180
  181 GKSFSRMDPE TCHVISVKEI VFQKKLFQR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.507 a.4.1 Homeodomain-like
View Download 0.501 a.4.1 Homeodomain-like
View Download 0.441 c.47.1 Thioredoxin-like
View Download 0.422 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.418 a.65.1 Annexin

Predicted Domain #2
Region A:
Residues: [210-585]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAANEDFPYL LTDPFTVKKK KELVKVELPT CPVCLERMDS ETTGLVTIPC QHTFHCQCLN  60
   61 KWKNSRCPVC RHSSLRLSRE SLLKQAGDSA HCATCGSTDN LWICLICGNV GCGRYNSKHA 120
  121 IKHYEETLHC FAMDIRTQRV WDYAGDNYVH RLVQNEVDGK LVEVGGSGDD DNNDIGNSDE 180
  181 LQNVVYGNRS KNGEKSNSNK KDGELAANFL RHREYHLEYV QVLISQLESQ REYYELKLQE 240
  241 KDQTASDSSN VESLKKSMED LKLQFQVTQK EWQKREMAQK SKLEEDMLVI EGLQANLDHL 300
  301 SKKQEQLERE NKALEESKQD LEEQVKDLMF YLDSQEKFKD ADESVKEGTI LIQQPHGAAQ 360
  361 ASKSKKKRNK NKKAGK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.09691
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.84044925655363 bayes_pls_golite062009
nucleic acid binding 2.16650337913343 bayes_pls_golite062009
RNA binding 1.55443392348354 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.3405047475504 bayes_pls_golite062009
small conjugating protein ligase activity 1.1717600698632 bayes_pls_golite062009
protein binding 1.05805521997665 bayes_pls_golite062009
acid-amino acid ligase activity 0.748751181289242 bayes_pls_golite062009
mRNA binding 0.372645027860457 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.205114038263623 bayes_pls_golite062009
hydrolase activity 0.181856784298799 bayes_pls_golite062009
protein phosphatase 2B binding 0.114018372525846 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [189-585]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PETCHVISVK EIVFQKKLFQ RPAANEDFPY LLTDPFTVKK KKELVKVELP TCPVCLERMD  60
   61 SETTGLVTIP CQHTFHCQCL NKWKNSRCPV CRHSSLRLSR ESLLKQAGDS AHCATCGSTD 120
  121 NLWICLICGN VGCGRYNSKH AIKHYEETLH CFAMDIRTQR VWDYAGDNYV HRLVQNEVDG 180
  181 KLVEVGGSGD DDNNDIGNSD ELQNVVYGNR SKNGEKSNSN KKDGELAANF LRHREYHLEY 240
  241 VQVLISQLES QREYYELKLQ EKDQTASDSS NVESLKKSME DLKLQFQVTQ KEWQKREMAQ 300
  301 KSKLEEDMLV IEGLQANLDH LSKKQEQLER ENKALEESKQ DLEEQVKDLM FYLDSQEKFK 360
  361 DADESVKEGT ILIQQPHGAA QASKSKKKRN KNKKAGK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.69897
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle