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View Structure Prediction Details

Protein: YHL008C
Organism: Saccharomyces cerevisiae
Length: 627 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YHL008C.

Description E-value Query
Range		 Subject
Range
YHL008C - Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appea...
YHA8_YEAST - Uncharacterized transporter YHL008C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YHL0...
 0.0 [1..627] [1..627]
gi|3850133 - gi|3850133|emb|CAA21934.1| transporter family [Candida albicans]
 0.0 [2..436] [1..387]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 2.0E-78 [5..279] [18..285]
gi|8071620 - gi|8071620|gb|AAF71816.1|AF141642_1 putative aquaporin PIP2-1 [Vitis berlandieri x Vitis rupestris]
 2.0E-77 [5..279] [16..280]
gi|3158476 - gi|3158476|gb|AAC17529.1| aquaporin 2 [Samanea saman]
 5.0E-77 [5..282] [16..286]
gi|13486938 - gi|13486938|dbj|BAB40141.1| plasma membrane intrinsic protein 2-1 [Pyrus communis]
 5.0E-77 [5..280] [16..280]
gi|255646628 - gi|255646628|gb|ACU23788.1| unknown [Glycine max]
PIP27_MAIZE - Aquaporin PIP2-7 OS=Zea mays GN=PIP2-7 PE=2 SV=1
 1.0E-76 [5..280] [17..286]
gi|17025878 - gi|17025878|gb|AAL32127.1| aquaporin [Medicago truncatula]
 1.0E-75 [5..280] [17..286]

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Predicted Domain #1
Region A:
Residues: [1-150] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDDSNYLTP HETALAVVAT AMKKARLQLD TLLINSILGG VLFSSGSFLL VAVYSEDPDI  60
   61 VARNPGIVNL ITGVNFAMGL FYVVMMGADL FNSNILFFSV GVLRKAVTIY DLMISWVVSW 120
  121 LGNIAGSLFV SYLFGHLSGI SSQKLWIIGS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.39794
Match: 1fqyA_
Description: Aquaporin-1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [151-317] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQIIEQKVSY SFVQTFLKGI ACNFFVCLAI YLQLMAKPIH VKFILMSFPI IDFIGIGFTH  60
   61 VVGDMSASFI AMLNGANVSV GKYIWKLLIP ASLGNIVGGL FFSAVVPFYL HLVVVERDRK 120
  121 RLSLPEYEAR DEQPELNMDS RVVRIQKNEC DDDATETGED LENLTEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.39794
Match: 1fqyA_
Description: Aquaporin-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
substrate-specific channel activity 4.290527875436 bayes_pls_golite062009
channel activity 4.28130462644143 bayes_pls_golite062009
passive transmembrane transporter activity 4.28130462644143 bayes_pls_golite062009
transporter activity 3.97659347318494 bayes_pls_golite062009
substrate-specific transporter activity 3.61874387899829 bayes_pls_golite062009
transmembrane transporter activity 3.53121060060615 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.25745583133819 bayes_pls_golite062009
water transmembrane transporter activity 2.7217137755064 bayes_pls_golite062009
water channel activity 2.56765170084404 bayes_pls_golite062009
ion transmembrane transporter activity 1.3732368130886 bayes_pls_golite062009
binding 0.839813420313223 bayes_pls_golite062009
cation transmembrane transporter activity 0.692853799846217 bayes_pls_golite062009
anion transmembrane transporter activity 0.570477584712317 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.357749002379944 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 0.309690615793197 bayes_pls_golite062009
organic acid transmembrane transporter activity 0.303822585218745 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [318-627] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFASIYNTNH DNSSYFTGRS LNSLRSIPSS VITSDNVTME SDLGEPVQFI PKSNSTTRSP  60
   61 HLGLPHNLPH NHSIKSINRH RINKRHSLRS PPGVFPVRGM GEPLEREKTI EDATYDPKEN 120
  121 ELFLRRAETH NSAYVKNKKK EDDNLLRLVK TEEDREQKEY EKNGGYNILE NKPGTRLEKI 180
  181 ITHLAENVSS REVTPPILPR TTQDTFPHNA PASSPAYTDD AHSLRKANST TLGGLFRAVS 240
  241 KEFHSSKDAE SPDDLLKKMA AVGINRNARI TANNVAGIVN LNKEDLDSTT RRQKITEPKN 300
  301 FYNRHTSPQL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle