YRC Public Data Repository - Protein Structure Prediction

Protein:	RNH70
Organism:	Saccharomyces cerevisiae
Length:	553 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RNH70.

Description	E-value	Query Range	Subject Range
YFE9_SCHPO - Uncharacterized exonuclease C637.09 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC63... SPAC637.09 - ribonuclease H70	436.0	[0..23]	[553..41]
SDN5_ARATH - Small RNA degrading nuclease 5 OS=Arabidopsis thaliana GN=SDN5 PE=2 SV=2	426.0	[0..18]	[532..4]
CG8368-PB, CG8368-PA - This gene is referred to in FlyBase by the symbol Dmel\CG8368 (CG8368, FBgn0035707). It is a protein... gi\|220951894 - gi\|220951894\|gb\|ACL88490.1\| CG8368-PA [synthetic construct]	319.0	[0..38]	[502..141]
gi\|13272524, gi\|... - gi\|13569913\|ref\|NP_112203.1\| exonuclease NEF-sp [Homo sapiens], gi\|13272524\|gb\|AAK17192.1\|AF332193_1...	288.0	[0..45]	[460..38]
gi\|114661383, gi... - gi\|114661391\|ref\|XP_001158108.1\| PREDICTED: exonuclease NEF-sp isoform 1 [Pan troglodytes], gi\|11466...	285.0	[0..45]	[460..38]
gi\|109127815, gi... - gi\|109127819\|ref\|XP_001088716.1\| PREDICTED: similar to exonuclease NEF-sp isoform 3 [Macaca mulatta]...	281.0	[0..45]	[460..38]
gi\|49640571 - gi\|49640571\|emb\|CAH03028.1\| KLLA0A10065p [Kluyveromyces lactis] gi\|50303005, gi\|... - gi\|50303005\|ref\|XP_451440.1\| unnamed protein product [Kluyveromyces lactis], gi\|49640571\|emb\|CAH0302...	281.0	[0..60]	[553..151]

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Predicted Domain #1

Region A:
Residues: [1-163]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQVEGPDTNF VSDLALGSKK RRLSKTSVQE DDHTNVVSEV NKNKKKKKAK PMTCTLLKSV  60
   61 VEKGIGIKDV RDMTQYLLQA ENNSPKWIDI CNRSSLQKMI VLFIPGLQPD DFENGKNTFN 120
  121 EISDDNFKYI PGEIASTFHT FPVMAPGSKM TLFSPYNSFI NVG

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [164-462]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSKMEKINKL KELQKKKKIT INDLVLSEQQ LVANDYPLDS GDTNFDTDWV QTVDFTHGGS  60
   61 HIFALDCEMC LSEQGLVLTR ISLVNFDNEV IYEELVKPDV PIVDYLTRYS GITEEKLTVG 120
  121 AKKTLREVQK DLLKIISRSD ILIGHSLQND LKVMKLKHPL VVDTAIIYHH KAGDPFKPSL 180
  181 KYLSETFLNK SIQNGEHDSV EDARACLELT KLKILNGLAF GIGINTENLF TKLHRFEVKT 240
  241 VLLNDMIIKN HTEDDSKGQL IRCVEDDETW THIHENLNKD VKLIVGRIKN LERSRNYNK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.30103
Match:	1dpiA
Description:	STRUCTURE OF LARGE FRAGMENT OF ESCHERICHIA COLI DNA POLYMERASE I COMPLEXED WITH D/TMP
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [463-553]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPRKETPSFD ASMVLHDIGQ HLTQLYENAT PGTMILIMSG TGDTRPWNNL STELEFIQDK  60
   61 KERLDKRRER EPEIVEAIKL ARGGVASFTV K

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits