YRC Public Data Repository - Protein Structure Prediction

Protein:	YGR210C
Organism:	Saccharomyces cerevisiae
Length:	411 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YGR210C.

Description	E-value	Query Range	Subject Range
YGR210C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to th... gi\|151943487 - gi\|151943487\|gb\|EDN61798.1\| conserved protein [Saccharomyces cerevisiae YJM789] YG4I_YEAST - Uncharacterized GTP-binding protein YGR210C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...	1.0E-85	[1..411]	[1..411]
gi\|7450709 - pir\|\|H71165 probable GTP-binding protein - Pyrococcus horikoshii gi\|3256930, gi\|1... - gi\|3256930\|dbj\|BAA29613.1\| 397aa long hypothetical GTP-binding protein [Pyrococcus horikoshii OT3], ...	4.0E-84	[7..403]	[3..393]
gi\|18976746, gi\|... - gi\|18976746\|ref\|NP_578103.1\| translation-associated GTPase [Pyrococcus furiosus DSM 3638], gi\|188923...	7.0E-84	[7..404]	[3..394]
gi\|5458942, gi\|7... - pir\|\|H75066 GTP-binding protein PAB1357 - Pyrococcus abyssi (strain Orsay), gi\|5458942\|emb\|CAB50429.... gi\|5458942, gi\|1... - gi\|5458942\|emb\|CAB50429.1\| GTP-binding protein [Pyrococcus abyssi GE5], gi\|14521723\|ref\|NP_127199.1\|...	2.0E-83	[7..404]	[3..394]
gi\|11496155 - gi\|11496155\|gb\|AAF97355.1\| Obg-like protein [Thermococcus zilligii]	2.0E-80	[7..406]	[3..396]
gi\|218773998, gi... - gi\|218893770\|ref\|YP_002442639.1\| GTP-dependent nucleic acid-binding protein EngD [Pseudomonas aerugi... gi\|107099660 - gi\|107099660\|ref\|ZP_01363578.1\| hypothetical protein PaerPA_01000678 [Pseudomonas aeruginosa PACS2] gi\|9950929, gi\|1... - gi\|9950929\|gb\|AAG08060.1\|AE004881_3 conserved hypothetical protein [Pseudomonas aeruginosa PAO1], gi... gi\|84317258, gi\|... - gi\|84317258\|ref\|ZP_00965709.1\| COG0012: Predicted GTPase, probable translation factor [Pseudomonas a... gi\|11348225 - pir\|\|A83061 conserved hypothetical protein PA4673 [imported] - Pseudomonas aeruginosa (strain PAO1) gi\|116052818, gi... - gi\|32039963\|ref\|ZP_00138235.1\| COG0012: Predicted GTPase, probable translation factor [Pseudomonas a...	2.0E-80	[7..407]	[5..365]
gi\|25328775, gi\|... - gi\|6015732\|emb\|CAB57559.1\| gtp-binding protein [Sulfolobus solfataricus], pir\|\|H90222 GTP binding pr... gi\|13813911, gi\|... - gi\|15897644\|ref\|NP_342249.1\| GTP binding protein [Sulfolobus solfataricus P2], gi\|13813911\|gb\|AAK410...	1.0E-79	[5..403]	[9..401]
ENGD_HAEIN - GTP-dependent nucleic acid-binding protein engD OS=Haemophilus influenzae GN=engD PE=1 SV=2 YCHF_HAEIN - Ribosome-binding ATPase YchF OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) G...	3.0E-79	[6..407]	[4..362]
gi\|15616613, gi\|... - gi\|15616613\|ref\|NP_244919.1\| translation-associated GTPase [Bacillus halodurans C-125], gi\|10176676\|... gi\|25330209 - pir\|\|C84156 GTP-binding protein BH4051 [imported] - Bacillus halodurans (strain C-125)	7.0E-79	[5..407]	[3..365]
gi\|11280368 - pir\|\|D81037 GTP-binding protein, probable NMB1838 [imported] - Neisseria meningitidis (strain MC58 s... gi\|121051586, gi... - gi\|7379353\|emb\|CAB83908.1\| hypothetical protein NMA0618 [Neisseria meningitidis Z2491], gi\|218767578... gi\|7227093, gi\|1... - gi\|7227093\|gb\|AAF42173.1\| putative GTP-binding protein [Neisseria meningitidis MC58], gi\|15677674\|re...	7.0E-79	[4..407]	[2..362]

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Predicted Domain #1

Region A:
Residues: [1-206]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRDPLIGIV GKPSSGKSTT LNSLTDAGAA VGAFPFTTIE PNQATGYLQV ECACSRFGKE  60
   61 DLCKPNYGWC SKGKRHIPIK LLDVAGLVPG AHSGRGLGNK FLDDLRHADA LIHVVDVSGT 120
  121 TDAEGKNTRG YDPLNDIEWL QDEIRLWVEG NLKKRWGSIV RKHTATKSSI VDTLQAQFGG 180
  181 YGSHAPMIQK ALDRLKGLPP LEKWDD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.154902
Match:	1egaA_
Description:	GTPase Era, N-terminal domain; GTPase Era C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.01156339800304	bayes_pls_golite062009
RNA helicase activity	1.02424782546779	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
RNA-dependent ATPase activity	0.95986988363392	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.94128341275411	bayes_pls_golite062009
helicase activity	0.86558574188931	bayes_pls_golite062009
ATP-dependent helicase activity	0.76276524160073	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.76276524160073	bayes_pls_golite062009
hydrolase activity	0.336064858580953	bayes_pls_golite062009
nucleic acid binding	0.163262043570117	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [207-347]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EWITRVVKSF MMEKFPTVLA LNKIDHPDAD KNVSKIMLKY PDTKAVLTSA VTEVFLRKLK  60
   61 KQGFILYEEG TEFVDTFEDE PDKLKPLDDK ILNRIENIRD LVLYRFGSTG VVQVLQAATD 120
  121 ILGLIPVYTV KNIQTFTGGN G

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.154902
Match:	1egaA_
Description:	GTPase Era, N-terminal domain; GTPase Era C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [348-411]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNVFRDCFLV KRGTPVGKVA RYIMGGEVTI ASIETVGGVR VSEESLVEPG KNDILGFKIA  60
   61 PRSA

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.697	0.631	cytoplasm	c.47.1	Thioredoxin-like
View	Download	0.540	0.080	cytoplasm	c.5.1	MurCD N-terminal domain
View	Download	0.857	N/A	N/A	d.37.1	CBS-domain
View	Download	0.518	N/A	N/A	d.68.5	C-terminal domain of ProRS
View	Download	0.496	N/A	N/A	c.58.1	Aminoacid dehydrogenase-like, N-terminal domain
View	Download	0.475	N/A	N/A	d.11.1	Penicillin-binding protein 2x (pbp-2x), c-terminal domain
View	Download	0.461	N/A	N/A	c.5.1	MurCD N-terminal domain
View	Download	0.455	N/A	N/A	d.58.3	Protease propeptides/inhibitors
View	Download	0.424	N/A	N/A	d.68.1	Translation initiation factor IF3, C-terminal domain
View	Download	0.399	N/A	N/A	d.15.1	Ubiquitin-like
View	Download	0.378	N/A	N/A	b.61.3	D-aminopeptidase, middle and C-terminal domains
View	Download	0.375	N/A	N/A	d.68.4	YhbY-like
View	Download	0.359	N/A	N/A	c.5.1	MurCD N-terminal domain
View	Download	0.351	N/A	N/A	c.51.1	Anticodon-binding domain of Class II aaRS
View	Download	0.329	N/A	N/A	b.1.2	Fibronectin type III
View	Download	0.323	N/A	N/A	d.15.3	MoaD/ThiS
View	Download	0.314	N/A	N/A	d.28.1	Ribosomal protein S19
View	Download	0.312	N/A	N/A	d.197.1	Protein-L-isoaspartyl O-methyltransferase, C-terminal domain
View	Download	0.302	N/A	N/A	c.30.1	PreATP-grasp domain
View	Download	0.276	N/A	N/A	d.7.1	LysM domain
View	Download	0.273	N/A	N/A	d.94.1	HPr-like
View	Download	0.271	N/A	N/A	g.3.7	Scorpion toxin-like
View	Download	0.270	N/A	N/A	g.10.1	Hairpin loop containing domain-like
View	Download	0.259	N/A	N/A	d.58.10	Acylphosphatase-like
View	Download	0.247	N/A	N/A	d.58.7	RNA-binding domain, RBD
View	Download	0.236	N/A	N/A	d.94.1	HPr-like
View	Download	0.231	N/A	N/A	b.12.1	Lipase/lipooxygenase domain (PLAT/LH2 domain)
View	Download	0.231	N/A	N/A	b.2.2	Carbohydrate-binding domain
View	Download	0.218	N/A	N/A	b.24.1	Hyaluronate lyase-like, C-terminal domain
View	Download	0.214	N/A	N/A	c.51.1	Anticodon-binding domain of Class II aaRS
View	Download	0.212	N/A	N/A	d.93.1	SH2 domain
View	Download	0.207	N/A	N/A	d.17.1	Cystatin/monellin
View	Download	0.202	N/A	N/A	c.2.1	NAD(P)-binding Rossmann-fold domains

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: