YRC Public Data Repository - Protein Structure Prediction

Protein:	YGR210C
Organism:	Saccharomyces cerevisiae
Length:	411 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YGR210C.

Description	E-value	Query Range	Subject Range
YGR210C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to th... gi\|151943487 - gi\|151943487\|gb\|EDN61798.1\| conserved protein [Saccharomyces cerevisiae YJM789] YG4I_YEAST - Uncharacterized GTP-binding protein YGR210C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...	1.0E-85	[1..411]	[1..411]
gi\|7450709 - pir\|\|H71165 probable GTP-binding protein - Pyrococcus horikoshii gi\|3256930, gi\|1... - gi\|3256930\|dbj\|BAA29613.1\| 397aa long hypothetical GTP-binding protein [Pyrococcus horikoshii OT3], ...	4.0E-84	[7..403]	[3..393]
gi\|18976746, gi\|... - gi\|18976746\|ref\|NP_578103.1\| translation-associated GTPase [Pyrococcus furiosus DSM 3638], gi\|188923...	7.0E-84	[7..404]	[3..394]
gi\|5458942, gi\|7... - pir\|\|H75066 GTP-binding protein PAB1357 - Pyrococcus abyssi (strain Orsay), gi\|5458942\|emb\|CAB50429.... gi\|5458942, gi\|1... - gi\|5458942\|emb\|CAB50429.1\| GTP-binding protein [Pyrococcus abyssi GE5], gi\|14521723\|ref\|NP_127199.1\|...	2.0E-83	[7..404]	[3..394]
gi\|11496155 - gi\|11496155\|gb\|AAF97355.1\| Obg-like protein [Thermococcus zilligii]	2.0E-80	[7..406]	[3..396]
gi\|218773998, gi... - gi\|218893770\|ref\|YP_002442639.1\| GTP-dependent nucleic acid-binding protein EngD [Pseudomonas aerugi... gi\|107099660 - gi\|107099660\|ref\|ZP_01363578.1\| hypothetical protein PaerPA_01000678 [Pseudomonas aeruginosa PACS2] gi\|9950929, gi\|1... - gi\|9950929\|gb\|AAG08060.1\|AE004881_3 conserved hypothetical protein [Pseudomonas aeruginosa PAO1], gi... gi\|84317258, gi\|... - gi\|84317258\|ref\|ZP_00965709.1\| COG0012: Predicted GTPase, probable translation factor [Pseudomonas a... gi\|11348225 - pir\|\|A83061 conserved hypothetical protein PA4673 [imported] - Pseudomonas aeruginosa (strain PAO1) gi\|116052818, gi... - gi\|32039963\|ref\|ZP_00138235.1\| COG0012: Predicted GTPase, probable translation factor [Pseudomonas a...	2.0E-80	[7..407]	[5..365]
gi\|25328775, gi\|... - gi\|6015732\|emb\|CAB57559.1\| gtp-binding protein [Sulfolobus solfataricus], pir\|\|H90222 GTP binding pr... gi\|13813911, gi\|... - gi\|15897644\|ref\|NP_342249.1\| GTP binding protein [Sulfolobus solfataricus P2], gi\|13813911\|gb\|AAK410...	1.0E-79	[5..403]	[9..401]
ENGD_HAEIN - GTP-dependent nucleic acid-binding protein engD OS=Haemophilus influenzae GN=engD PE=1 SV=2 YCHF_HAEIN - Ribosome-binding ATPase YchF OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) G...	3.0E-79	[6..407]	[4..362]
gi\|15616613, gi\|... - gi\|15616613\|ref\|NP_244919.1\| translation-associated GTPase [Bacillus halodurans C-125], gi\|10176676\|... gi\|25330209 - pir\|\|C84156 GTP-binding protein BH4051 [imported] - Bacillus halodurans (strain C-125)	7.0E-79	[5..407]	[3..365]
gi\|11280368 - pir\|\|D81037 GTP-binding protein, probable NMB1838 [imported] - Neisseria meningitidis (strain MC58 s... gi\|121051586, gi... - gi\|7379353\|emb\|CAB83908.1\| hypothetical protein NMA0618 [Neisseria meningitidis Z2491], gi\|218767578... gi\|7227093, gi\|1... - gi\|7227093\|gb\|AAF42173.1\| putative GTP-binding protein [Neisseria meningitidis MC58], gi\|15677674\|re...	7.0E-79	[4..407]	[2..362]

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Predicted Domain #1

Region A:
Residues: [1-206]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRDPLIGIV GKPSSGKSTT LNSLTDAGAA VGAFPFTTIE PNQATGYLQV ECACSRFGKE  60
   61 DLCKPNYGWC SKGKRHIPIK LLDVAGLVPG AHSGRGLGNK FLDDLRHADA LIHVVDVSGT 120
  121 TDAEGKNTRG YDPLNDIEWL QDEIRLWVEG NLKKRWGSIV RKHTATKSSI VDTLQAQFGG 180
  181 YGSHAPMIQK ALDRLKGLPP LEKWDD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.154902
Match:	1egaA_
Description:	GTPase Era, N-terminal domain; GTPase Era C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.01156339800304	bayes_pls_golite062009
RNA helicase activity	1.02424782546779	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
RNA-dependent ATPase activity	0.95986988363392	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.94128341275411	bayes_pls_golite062009
helicase activity	0.86558574188931	bayes_pls_golite062009
ATP-dependent helicase activity	0.76276524160073	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.76276524160073	bayes_pls_golite062009
hydrolase activity	0.336064858580953	bayes_pls_golite062009
nucleic acid binding	0.163262043570117	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [207-347]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EWITRVVKSF MMEKFPTVLA LNKIDHPDAD KNVSKIMLKY PDTKAVLTSA VTEVFLRKLK  60
   61 KQGFILYEEG TEFVDTFEDE PDKLKPLDDK ILNRIENIRD LVLYRFGSTG VVQVLQAATD 120
  121 ILGLIPVYTV KNIQTFTGGN G

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.154902
Match:	1egaA_
Description:	GTPase Era, N-terminal domain; GTPase Era C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [348-411]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNVFRDCFLV KRGTPVGKVA RYIMGGEVTI ASIETVGGVR VSEESLVEPG KNDILGFKIA  60
   61 PRSA

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.857	N/A	N/A	d.37.1	CBS-domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: