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View Structure Prediction Details

Protein: TEL2
Organism: Saccharomyces cerevisiae
Length: 688 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TEL2.

Description E-value Query
Range
Subject
Range
gi|1181669 - gi|1181669|gb|AAB60317.1| Tel2p
0.0 [1..688] [1..688]
TEL2_SCHPO - DNA replication checkpoint protein tel2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=te...
SPAC458.03 - nuclear telomere cap complex subunit
0.0 [302..655] [350..742]
TELO2 - TEL2, telomere maintenance 2, homolog (S. cerevisiae)
2.0E-91 [315..658] [379..738]
gi|42602056, gi|... - gi|42602056|gb|AAS21644.1| unknown; 1200003M09Rik protein [Mus musculus], gi|15029722|gb|AAH11077.1|...
6.0E-87 [316..626] [380..704]
gi|30693041, gi|... - gi|7630034|emb|CAB88328.1| putative protein [Arabidopsis thaliana], gi|30693041|ref|NP_680117.2| EMB...
5.0E-74 [311..625] [446..837]
clk-2 - status:Confirmed UniProt:Q95YE9 protein_id:AAK85444.3
3.0E-55 [400..626] [504..739]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLETLKQGL DSSQIHEALI QLDSYPREPV DLDASMVLIK FVIPVYPSLP ERSKVILRRL  60
   61 ASKSFTFLCQ IVTFSRTISG RDGLQEIRIY QEILEDIISF EPGCLTFYLK ASTTSKADRD 120
  121 SIKALFFGSK LFNVLANRID MAKYLGYLRL QWKFLLES

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [159-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NETDPPGFLG EWLVSSFLLN PVLAADMLLG ELFLLKESYF FSFQKIISAS SLIDQKRLIA  60
   61 KFLLPYIQVI VTLENLNDVR KILRRFDLDK IISLSVLFEI QSLPLKEVIV RLMSNHSSTK 120
  121 FVSALVSKFA DFTDEEVDTK TCELLVLFAV HNLNHSQREE IAHDERFL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [346-408]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FIAKLLSGGH LKYESDFKIN IPNVKFESNS DDKIIDFQSL KNPSICNTQT DVGKDKITEV  60
   61 SGH

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.14
Match: 1h6kA
Description: CBP80, 80KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [327-345]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGVTKHLGSN EREARERAM

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [409-552]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQSLTLDCSD SDDEDENDER EIVKRIVFLK DLMKEYEKTG ESRKAPLIPL LKQTVKLIRQ  60
   61 KADFQLEVGY YAQGILSSIV CLNNEFDEPL FEQWRINALT SILVVLPEKV NGAINILFNS 120
  121 ELSLQQRMSL LSALGLSARE LRGL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.14
Match: 1h6kA
Description: CBP80, 80KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [553-688]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDPTIVKPKF DFPTNRLPWD DQSHHNSRLV EVQESTSMIK KTKTVWKSRK LGKDREKGTQ  60
   61 NRFRKYAGLF FYPLAHGWLN GIDVGTYNQL FKSHYLTTLR IIYSCANPVH DFESMTELMN 120
  121 HIISSAIEEG ISLNKG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.569 a.133.1 Phospholipase A2, PLA2
View Download 0.555 a.24.3 Cytochromes
View Download 0.509 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.442 a.24.4 Hemerythrin
View Download 0.593 a.63.1 Apolipophorin-III
View Download 0.419 a.133.1 Phospholipase A2, PLA2
View Download 0.412 d.110.4 SNARE-like
View Download 0.392 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.385 a.24.4 Hemerythrin
View Download 0.385 a.24.4 Hemerythrin
View Download 0.378 a.63.1 Apolipophorin-III
View Download 0.366 d.54.1 Enolase N-terminal domain-like
View Download 0.360 a.118.1 ARM repeat
View Download 0.353 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.335 a.24.17 Group V grass pollen allergen
View Download 0.309 a.24.9 alpha-catenin/vinculin
View Download 0.292 e.20.1 Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
View Download 0.289 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.287 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.271 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.267 a.24.17 Group V grass pollen allergen
View Download 0.265 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.263 a.18.1 T4 endonuclease V
View Download 0.261 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.261 a.24.4 Hemerythrin
View Download 0.260 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.238 a.39.1 EF-hand
View Download 0.230 e.37.1 Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains
View Download 0.223 a.118.1 ARM repeat
View Download 0.217 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.213 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.209 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.207 a.118.7 14-3-3 protein
View Download 0.207 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.205 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.202 a.118.9 ENTH/VHS domain
View Download 0.202 a.63.1 Apolipophorin-III

Predicted Domain #5
Region A:
Residues: [559-688]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPKFDFPTNR LPWDDQSHHN SRLVEVQEST SMIKKTKTVW KSRKLGKDRE KGTQNRFRKY  60
   61 AGLFFYPLAH GWLNGIDVGT YNQLFKSHYL TTLRIIYSCA NPVHDFESMT ELMNHIISSA 120
  121 IEEGISLNKG 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.593 a.63.1 Apolipophorin-III
View Download 0.569 a.133.1 Phospholipase A2, PLA2
View Download 0.555 a.24.3 Cytochromes
View Download 0.509 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.442 a.24.4 Hemerythrin


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle