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View Structure Prediction Details

Protein: YGR054W
Organism: Saccharomyces cerevisiae
Length: 642 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YGR054W.

Description E-value Query
Range
Subject
Range
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=...
gi|25530855 - pir||AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)
0.0 [3..623] [918..1512]
YGR054W - Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribos...
EIF2A_YEAST - Eukaryotic translation initiation factor 2A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
gi|151943334 - gi|151943334|gb|EDN61647.1| conserved protein [Saccharomyces cerevisiae YJM789]
0.0 [1..642] [1..642]
gi|17225208 - gi|17225208|gb|AAL37300.1|AF323584_1 beta transducin-like protein HET-E2C*40 [Podospora anserina]
0.0 [12..498] [822..1256]

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Predicted Domain #1
Region A:
Residues: [1-362]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSQFFLKTS QDIELFQSYP TFEQSNTNSK DFPVISSVLS PCGRFLALST KENVKVFTGP  60
   61 CLDNVLLTMK LSDVYDLHFS PAGNYLSTWE RASIQDPNHK NVKVWYLNKP FKKDCVSEDI 120
  121 VPAYEYQAKS QSGWFLQFSK LDNYGLRLFK HDLKIVKLSS ANADNFDFQS PFAVLSDDET 180
  181 SQHFTTYLIS PAEHPTICTF TPEKGGKPAQ LIIWALSEGK ITKKIASKTF FKADSCQLKW 240
  241 NPLGNAILCL AITDFDSSNK SYYGENTLYL LSFQGVNGTL GGNSVRVSLT TGPVHDFTWS 300
  301 PTSRQFGVIA GYMPATISFF DLRGNVVHSL PQQAKNTMLF SPSGHYILIA GFGNLQGSVE 360
  361 IL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.0
Match: 1erjA_
Description: Tup1, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural molecule activity 5.05435272846365 bayes_pls_golite062009
snoRNA binding 2.69983094099712 bayes_pls_golite062009
translation initiation factor activity 2.29806492548141 bayes_pls_golite062009
binding 1.99637157021613 bayes_pls_golite062009
RNA binding 1.54614730254863 bayes_pls_golite062009
1.53488375271101 bayes_pls_golite062009
nucleic acid binding 1.24195336789614 bayes_pls_golite062009
transcription regulator activity 1.21914661317312 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
DNA binding 0.694865434683509 bayes_pls_golite062009
cytoskeletal protein binding 0.523052412917759 bayes_pls_golite062009
mRNA binding 0.273021928390838 bayes_pls_golite062009
transcription factor activity 0.130013114814281 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [363-497]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRLDKFKCVS KFDATNTSVC KWSPGGEFIM TATTSPRLRV DNGVKIWHVS GSLVFVKEFK  60
   61 ELLKVDWRSP CNYKTLENKD EAFFENHIIN NWEPLPDSTT SSLDPKISNK SELQIHSSVQ 120
  121 EYISQHPSRE ASSNG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.30103
Match: 1gxrA_
Description: Groucho/tle1, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [498-642]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGSKAKAGGA YKPPHARRTG GGRIVPGVPP GAAKKTIPGL VPGMSANKDA NTKNRRRRAN  60
   61 KKSSETSPDS TPAPSAPAST NAPTNNKETS PEEKKIRSLL KKLRAIETLK ERQAVGDKLE 120
  121 DTQVLKIQTE EKVLKDLEKL GWKDE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.269 N/A N/A a.1.1 Globin-like
View Download 0.518 N/A N/A a.25.1 Ferritin-like
View Download 0.518 0.074 ribosome a.25.1 Ferritin-like
View Download 0.442 0.004 ribosome a.63.1 Apolipophorin-III
View Download 0.440 N/A N/A a.25.1 Ferritin-like
View Download 0.440 N/A N/A a.25.1 Ferritin-like
View Download 0.392 N/A N/A a.25.1 Ferritin-like
View Download 0.392 N/A N/A a.25.1 Ferritin-like
View Download 0.333 N/A N/A d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.333 N/A N/A d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.253 N/A N/A a.63.1 Apolipophorin-III
View Download 0.239 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.227 N/A N/A f.35.1 Multidrug efflux transporter AcrB transmembrane domain
View Download 0.219 N/A N/A a.24.1 Apolipoprotein
View Download 0.214 N/A N/A a.25.1 Ferritin-like
View Download 0.214 N/A N/A c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.205 N/A N/A c.14.1 ClpP/crotonase


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle