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Protein Overview: EIF2A_YEAST

General Information:
Name(s) found: EIF2A_YEAST [Swiss-Prot]
Description(s) found:
  • Eukaryotic translation initiation factor 2A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YGR054W PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 642 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSQFFLKTS QDIELFQSYP TFEQSNTNSK DFPVISSVLS PCGRFLALST KENVKVFTGP  60
   61 CLDNVLLTMK LSDVYDLHFS PAGNYLSTWE RASIQDPNHK NVKVWYLNKP FKKDCVSEDI 120
  121 VPAYEYQAKS QSGWFLQFSK LDNYGLRLFK HDLKIVKLSS ANADNFDFQS PFAVLSDDET 180
  181 SQHFTTYLIS PAEHPTICTF TPEKGGKPAQ LIIWALSEGK ITKKIASKTF FKADSCQLKW 240
  241 NPLGNAILCL AITDFDSSNK SYYGENTLYL LSFQGVNGTL GGNSVRVSLT TGPVHDFTWS 300
  301 PTSRQFGVIA GYMPATISFF DLRGNVVHSL PQQAKNTMLF SPSGHYILIA GFGNLQGSVE 360
  361 ILDRLDKFKC VSKFDATNTS VCKWSPGGEF IMTATTSPRL RVDNGVKIWH VSGSLVFVKE 420
  421 FKELLKVDWR SPCNYKTLEN KDEAFFENHI INNWEPLPDS TTSSLDPKIS NKSELQIHSS 480
  481 VQEYISQHPS REASSNGNGS KAKAGGAYKP PHARRTGGGR IVPGVPPGAA KKTIPGLVPG 540
  541 MSANKDANTK NRRRRANKKS SETSPDSTPA PSAPASTNAP TNNKETSPEE KKIRSLLKKL 600
  601 RAIETLKERQ AVGDKLEDTQ VLKIQTEEKV LKDLEKLGWK DE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..362] PSI-BLAST 50.0 Tup1, C-terminal domain
    2 View Details [363..497] PSI-BLAST 20.30103 Groucho/tle1, C-terminal domain
    3 View Details [498..642] MSA 3.247996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • structural molecule activity
    		•  5.05435272846365 bayes_pls_golite062009
  • snoRNA binding
    		•  2.69983094099712 bayes_pls_golite062009
  • translation initiation factor activity
    		•  2.29806492548141 bayes_pls_golite062009
  • binding
    		•  1.99637157021613 bayes_pls_golite062009
  • RNA binding
    		•  1.54614730254863 bayes_pls_golite062009
    		• 1.53488375271101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.24195336789614 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.21914661317312 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • DNA binding
    		•  0.694865434683509 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.523052412917759 bayes_pls_golite062009
  • mRNA binding
    		•  0.273021928390838 bayes_pls_golite062009
  • transcription factor activity
    		•  0.130013114814281 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle