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View Structure Prediction Details

Protein: NMA2
Organism: Saccharomyces cerevisiae
Length: 395 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NMA2.

Description E-value Query
Range
Subject
Range
NMA2 - Nicotinic acid mononucleotide adenylyltransferase, involved in de novo and salvage synthesis of NAD(...
NMA2_YEAST - Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 OS=Saccharomyces cerevisiae (strain...
0.0 [1..395] [1..395]
SPAC806.06c - nicotinamide mononucleotide (NMN) adenylyltransferase
NMAH_SCHPO - Putative nicotinamide-nucleotide adenylyltransferase C806.06c OS=Schizosaccharomyces pombe (strain 9...
3.0E-99 [57..390] [12..354]
gi|11596129, gi|... - gi|11596129|gb|AAG38490.1|AF260927_1 D4Cole1e [Mus musculus], gi|10442021|gb|AAG17286.1|AF260925_1 D...
1.0E-69 [146..385] [75..340]
NMNAT1 - nicotinamide nucleotide adenylyltransferase 1
2.0E-68 [152..385] [1..259]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPTKAPDFK PPQPNEELQP PPDPTHTIPK SGPIVPYVLA DYNSSIDAPF NLDIYKTLSS  60
   61 RKKNANSSNR MDHIPLNTSD FQPLSRDVSS EEESEGQSNG IDATLQDVTM TG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [113-395]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLGVLKSQIA DLEEVPHTIV RQARTIEDYE FPVHRLTKKL QDPEKLPLII VACGSFSPIT  60
   61 YLHLRMFEMA LDDINEQTRF EVVGGYFSPV SDNYQKRGLA PAYHRVRMCE LACERTSSWL 120
  121 MVDAWESLQS SYTRTAKVLD HFNHEINIKR GGIMTVDGEK MGVKIMLLAG GDLIESMGEP 180
  181 HVWADSDLHH ILGNYGCLIV ERTGSDVRSF LLSHDIMYEH RRNILIIKQL IYNDISSTKV 240
  241 RLFIRRGMSV QYLLPNSVIR YIQEYNLYIN QSEPVKQVLD SKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 604.228787
Match: 1kkuA_
Description: Nicotinamide mononucleotide (NMN) adenylyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ligase activity, forming aminoacyl-tRNA and related compounds 5.66762539052452 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 5.66762539052452 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 5.65398773296369 bayes_pls_golite062009
ligase activity 4.61911329839139 bayes_pls_golite062009
nicotinate-nucleotide adenylyltransferase activity 2.94996967804011 bayes_pls_golite062009
nicotinamide-nucleotide adenylyltransferase activity 2.8149071156304 bayes_pls_golite062009
catalytic activity 2.37674226834122 bayes_pls_golite062009
glutamate-tRNA ligase activity 2.21467185575886 bayes_pls_golite062009
methionine-tRNA ligase activity 2.14891246680781 bayes_pls_golite062009
nucleic acid binding 1.64840822019417 bayes_pls_golite062009
tyrosine-tRNA ligase activity 1.47110858685627 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.32767284282317 bayes_pls_golite062009
binding 1.11291710031577 bayes_pls_golite062009
arginine-tRNA ligase activity 1.0861830757171 bayes_pls_golite062009
adenylyltransferase activity 1.08055019963499 bayes_pls_golite062009
tryptophan-tRNA ligase activity 0.725178047574893 bayes_pls_golite062009
nucleotidyltransferase activity 0.564359271862248 bayes_pls_golite062009
pantetheine-phosphate adenylyltransferase activity 0.454904507512502 bayes_pls_golite062009
cysteine-tRNA ligase activity 0.430902479559327 bayes_pls_golite062009
transferase activity 0.364668631710285 bayes_pls_golite062009
pantoate-beta-alanine ligase activity 0.282286652169846 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle