YRC Public Data Repository - Protein Structure Prediction

Protein:	PRP18
Organism:	Saccharomyces cerevisiae
Length:	219 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP18.

Description	E-value	Query Range	Subject Range
PRP18_YEAST - Pre-mRNA-splicing factor 18 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP18 PE=1 S... PRP18 - Splicing factor involved in the positioning of the 3' splice site during the second catalytic step o... gi\|151943293 - gi\|151943293\|gb\|EDN61606.1\| RNA splicing factor [Saccharomyces cerevisiae YJM789]	9.0E-86	[1..211]	[1..207]
gi\|15221867, gi\|... - gi\|3776560\|gb\|AAC64877.1\| Similar to gb\|U51990 hPrp18 (splicing factor) gene from Homo sapiens. [Ara...	4.0E-46	[59..213]	[1..171]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-44	[51..213]	[146..295]
gi\|114629422, gi... - gi\|114629424\|ref\|XP_001142558.1\| PREDICTED: PRP18 pre-mRNA processing factor 18 homolog isoform 6 [P... PRPF18 - PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae) gi\|109088233 - gi\|109088233\|ref\|XP_001086905.1\| PREDICTED: PRP18 pre-mRNA processing factor 18 homolog isoform 5 [M...	2.0E-43	[51..213]	[146..295]
prp18 - U5 snRNP-associated protein Prp18 PRP18_SCHPO - Pre-mRNA-splicing factor 18 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=prp18 PE=3 SV=...	1.0E-24	[114..211]	[207..299]

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Predicted Domain #1

Region A:
Residues: [1-78]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLDLASILK GEISKKKKEL ANSKGVQPPC TEKFQPHESA NIDETPRQVE QESTDEENLS  60
   61 DNQSDDIRTT ISKLENRP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [79-219]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERIQEAIAQD KTISVIIDPS QIGSTEGKPL LSMKCNLYIH EILSRWKASL EAYHPELFLD  60
   61 TKKALFPLLL QLRRNQLAPD LLISLATVLY HLQQPKEINL AVQSYMKLSI GNVAWPIGVT 120
  121 SVAFMLVVHI RKFKEAGMLL T

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	619.70927
Match:	1dvkA_
Description:	Functional domain of the splicing factor Prp18
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits