YRC Public Data Repository - Protein Structure Prediction

Protein:	PRP18
Organism:	Saccharomyces cerevisiae
Length:	219 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP18.

Description	E-value	Query Range	Subject Range
PRP18_YEAST - Pre-mRNA-splicing factor 18 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP18 PE=1 S... PRP18 - Splicing factor involved in the positioning of the 3' splice site during the second catalytic step o... gi\|151943293 - gi\|151943293\|gb\|EDN61606.1\| RNA splicing factor [Saccharomyces cerevisiae YJM789]	9.0E-86	[1..211]	[1..207]
gi\|15221867, gi\|... - gi\|3776560\|gb\|AAC64877.1\| Similar to gb\|U51990 hPrp18 (splicing factor) gene from Homo sapiens. [Ara...	4.0E-46	[59..213]	[1..171]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-44	[51..213]	[146..295]
gi\|114629422, gi... - gi\|114629424\|ref\|XP_001142558.1\| PREDICTED: PRP18 pre-mRNA processing factor 18 homolog isoform 6 [P... PRPF18 - PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae) gi\|109088233 - gi\|109088233\|ref\|XP_001086905.1\| PREDICTED: PRP18 pre-mRNA processing factor 18 homolog isoform 5 [M...	2.0E-43	[51..213]	[146..295]
prp18 - U5 snRNP-associated protein Prp18 PRP18_SCHPO - Pre-mRNA-splicing factor 18 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=prp18 PE=3 SV=...	1.0E-24	[114..211]	[207..299]

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Predicted Domain #1

Region A:
Residues: [1-78]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLDLASILK GEISKKKKEL ANSKGVQPPC TEKFQPHESA NIDETPRQVE QESTDEENLS  60
   61 DNQSDDIRTT ISKLENRP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.316	a.39.1	EF-hand
View	Download	0.368	a.35.1	lambda repressor-like DNA-binding domains
View	Download	0.231	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.253	a.42.1	MDM2
View	Download	0.216	a.36.1	Signal peptide-binding domain

Predicted Domain #2

Region A:
Residues: [79-219]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERIQEAIAQD KTISVIIDPS QIGSTEGKPL LSMKCNLYIH EILSRWKASL EAYHPELFLD  60
   61 TKKALFPLLL QLRRNQLAPD LLISLATVLY HLQQPKEINL AVQSYMKLSI GNVAWPIGVT 120
  121 SVAFMLVVHI RKFKEAGMLL T

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	619.70927
Match:	1dvkA_
Description:	Functional domain of the splicing factor Prp18
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits