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View Structure Prediction Details

Protein: INO80
Organism: Saccharomyces cerevisiae
Length: 1489 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for INO80.

Description E-value Query
Range
Subject
Range
gi|6330933 - gi|6330933|dbj|BAA86573.1| KIAA1259 protein [Homo sapiens]
0.0 [296..1488] [132..1293]
gi|17862908 - gi|17862908|gb|AAL39931.1| SD02886p [Drosophila melanogaster]
0.0 [267..1488] [47..1341]
gi|11994423 - gi|11994423|dbj|BAB02425.1| helicase-like protein [Arabidopsis thaliana]
0.0 [163..1486] [2..1264]
SWR1 - Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histo...
SWR1_YEAST - Helicase SWR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SWR1 PE=1 SV=1
gi|151942310 - gi|151942310|gb|EDN60666.1| SWR1 complex component [Saccharomyces cerevisiae YJM789]
0.0 [53..1481] [3..1433]
gi|996018, gi|45... - gi|996018|emb|CAA62831.1| BRG1 protein [Gallus gallus], gi|45384232|ref|NP_990390.1| BRG1 protein [G...
0.0 [282..1261] [345..1324]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
0.0 [282..1185] [346..1245]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [282..1185] [346..1245]

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Predicted Domain #1
Region A:
Residues: [1-420]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLAVLLNKE DKDISDFSKT TAGKSAKKNS RERVADVAPT RVLDKKQAYL SQLNSEFNRI  60
   61 KRRDSIEQLY QDWKFINLQE FELISEWNQQ SKDWQFDNTN DSQDLHFKKL YRDMSMINKE 120
  121 WAEYQSFKNA NLSDIINEKD ADEDEEDDED ELEDGEEDME EDEASTGRHT NGKSMRGNGI 180
  181 QKSRKKDAAA AAAIGKAIKD DQTHADTVVT VNGDENEDGN NGEDEDNDND NENNNDNDND 240
  241 NENENDNDSD NDDEEENGEE DEEEEEIEDL DEEDFAAFEE QDDNDDEDFN PDVEKRRKRS 300
  301 SSSSSSTKLS MNSLSLITSK KINKNITINS DRPKIVRELI KMCNKNKHQK IKKRRFTNCI 360
  361 VTDYNPIDSK LNIKITLKQY HVKRLKKLIN DAKREREREE ALKNNVGLDG NDLDNDEDGS 420
  421 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.154902
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [421-637]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESHKRRKLNN NTANGADDAN KRKFNTRHGL PTYGMKMNAK EARAIQRHYD NTYTTIWKDM  60
   61 ARKDSTKMSR LVQQIQSIRS TNFRKTSSLC AREAKKWQSK NFKQIKDFQT RARRGIREMS 120
  121 NFWKKNEREE RDLKKKIEKE AMEQAKKEEE EKESKRQAKK LNFLLTQTEL YSHFIGRKIK 180
  181 TNELEGNNVS SNDSESQKNI DISALAPNKN DFHAIDF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [638-956]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNENDEQLRL RAAENASNAL AETRAKAKQF DDHANAHEEE EEEDELNFQN PTSLGEITIE  60
   61 QPKILACTLK EYQLKGLNWL ANLYDQGING ILADEMGLGK TVQSISVLAH LAENHNIWGP 120
  121 FLVVTPASTL HNWVNEISKF LPQFKILPYW GNANDRKVLR KFWDRKNLRY NKNAPFHVMV 180
  181 TSYQMVVTDA NYLQKMKWQY MILDEAQAIK SSQSSRWKNL LSFHCRNRLL LTGTPIQNSM 240
  241 QELWALLHFI MPSLFDSHDE FNEWFSKDIE SHAEANTKLN QQQLRRLHMI LKPFMLRRVK 300
  301 KNVQSELGDK IEIDVLCDL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.8
Match: 1gm5A
Description: RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [957-1182]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQRQAKLYQV LKSQISTNYD AIENAATNDS TSNSASNSGS DQNLINAVMQ FRKVCNHPDL  60
   61 FERADVDSPF SFTTFGKTTS MLTASVANNN SSVISNSNMN LSSMSSNNIS NGKFTDLIYS 120
  121 SRNPIKYSLP RLIYEDLILP NYNNDVDIAN KLKNVKFNIF NPSTNYELCL FLSKLTGEPS 180
  181 LNEFFRVSTT PLLKRVIERT NGPKNTDSLS FKTITQELLE VTRNAP

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.8
Match: 1gm5A
Description: RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.470983068319171 bayes_pls_golite062009
hydrolase activity 0.0582794297634999 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [1183-1414]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEGVMASLLN VEKHAYEREY LNCIQRGYHP NVSAPPVTIE VLGSSHVTNS INNELFDPLI  60
   61 SQALSDIPAI TQYNMHVKKG IPVEDFPKTG LFPEPLNKNF SSNISMPSMD RFITESAKLR 120
  121 KLDELLVKLK SEGHRVLIYF QMTKMMDLME EYLTYRQYNH IRLDGSSKLE DRRDLVHDWQ 180
  181 TNPEIFVFLL STRAGGLGIN LTAADTVIFY DSDWNPTIDS QAMDRAHRLG QT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.39794
Match: 1hv8A_
Description: Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1415-1489]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQVTVYRLLV RGTIEERMRD RAKQKEQVQQ VVMEGKTQEK NIKTIEVGEN DSEVTREGSK  60
   61 SISQDGIKEA ASALA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.486 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.566 a.60.1 SAM/Pointed domain
View Download 0.513 c.30.1 PreATP-grasp domain
View Download 0.671 d.80.1 Tautomerase/MIF
View Download 0.488 a.24.17 Group V grass pollen allergen
View Download 0.439 d.58.3 Protease propeptides/inhibitors
View Download 0.433 a.24.4 Hemerythrin
View Download 0.398 d.68.4 YhbY-like
View Download 0.374 a.74.1 Cyclin-like
View Download 0.363 d.109.1 Actin depolymerizing proteins
View Download 0.342 c.97.1 Cytidine deaminase-like
View Download 0.336 d.68.3 SirA-like
View Download 0.326 d.52.1 Alpha-lytic protease prodomain
View Download 0.313 a.51.1 Cytochrome c oxidase subunit h
View Download 0.297 a.4.5 "Winged helix" DNA-binding domain
View Download 0.289 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.287 d.226.1 GIY-YIG endonuclease
View Download 0.284 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.281 c.66.1 S-adenosyl-L-methionine-dependent methyltransferases
View Download 0.272 c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.262 c.16.1 Lumazine synthase
View Download 0.256 d.88.1 SRF-like
View Download 0.247 d.80.1 Tautomerase/MIF
View Download 0.235 d.88.1 SRF-like
View Download 0.229 c.30.1 PreATP-grasp domain
View Download 0.219 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.215 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.214 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.212 c.55.4 Translational machinery components
View Download 0.211 c.55.4 Translational machinery components
View Download 0.208 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.206 c.16.1 Lumazine synthase
View Download 0.203 d.79.1 YjgF-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle