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View Structure Prediction Details

Protein: PRP43
Organism: Saccharomyces cerevisiae
Length: 767 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP43.

Description E-value Query
Range
Subject
Range
gi|151943690 - gi|151943690|gb|EDN62000.1| RNA helicase [Saccharomyces cerevisiae YJM789]
PRP43 - RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript...
PRP43_YEAST - Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 OS=Saccharomyces cerevisiae (strain ATCC 2...
0.0 [1..753] [1..753]
DEAH2_ARATH - Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 OS=Arabidopsis thaliana GN=At3g62...
0.0 [36..759] [4..726]
DHX15_SCHPO - Probable pre-mRNA-splicing factor ATP-dependent RNA helicase prp43 OS=Schizosaccharomyces pombe (str...
prp43 - ATP-dependent RNA helicase Prp43
0.0 [20..756] [3..735]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [3..754] [10..768]
gi|85080337 - gi|85080337|ref|XP_956523.1| probable ATP-binding protein PRP16 [MIPS] [Neurospora crassa OR74A]
gi|32415143, gi|... - gi|32415143|ref|XP_328051.1| probable ATP-binding protein PRP16 [MIPS] [Neurospora crassa], gi|28917...
0.0 [3..754] [10..768]
FBpp0307849, CG1... - This gene is referred to in FlyBase by the symbol Dmel\CG11107 (CG11107, FBgn0033160). It is a prote...
gi|220947046 - gi|220947046|gb|ACL86066.1| CG11107-PA [synthetic construct]
0.0 [68..748] [47..721]
gi|114593352 - gi|114593352|ref|XP_001164599.1| PREDICTED: similar to Putative pre-mRNA-splicing factor ATP-depende...
DHX15 - DEAH (Asp-Glu-Ala-His) box polypeptide 15
0.0 [3..743] [43..783]

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Predicted Domain #1
Region A:
Residues: [1-70]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSKRRFSSE HPDPVETSIP EQAAEIAEEL SKQHPLPSEE PLVHHDAGEF KGLQRHHTSA  60
   61 EEAQKLEDGK 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.557 a.77.1 DEATH domain
View Download 0.517 a.28.2 Colicin E immunity proteins
View Download 0.359 d.74.2 C-terminal domain of arginine repressor
View Download 0.371 a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.377 a.60.11 Hypothetical protein YjbJ
View Download 0.337 a.144.1 PABC (PABP) domain
View Download 0.335 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.317 a.28.1 ACP-like
View Download 0.293 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.278 a.28.1 ACP-like
View Download 0.273 a.40.1 Calponin-homology domain, CH-domain
View Download 0.255 d.58.17 Metal-binding domain
View Download 0.250 a.64.1 Saposin
View Download 0.250 d.45.1 ClpS-like
View Download 0.241 a.144.2 Ribosomal protein L20
View Download 0.236 a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.222 d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.215 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.214 d.2.1 Lysozyme-like
View Download 0.212 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.206 a.28.1 ACP-like
View Download 0.205 a.77.1 DEATH domain
View Download 0.205 d.58.18 Regulatory domain in the aminoacid metabolism

Predicted Domain #2
Region A:
Residues: [71-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INPFTGREFT PKYVDILKIR RELPVHAQRD EFLKLYQNNQ IMVFVGETGS GKTTQIPQFV  60
   61 LFDEMPHLEN TQVACTQPRR VAAMSVAQRV AEEMDVKLGE EVGYSIRFEN KTSNKTILKY 120
  121 MTDGMLLREA MEDHDLSRYS CIILDEAHER TLATDILMGL LKQVVKRRPD LKIIIMSATL 180
  181 DAEKFQRYFN DAPLLAVPGR TYP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.69897
Match: 1hv8A_
Description: Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [274-453]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VELYYTPEFQ RDYLDSAIRT VLQIHATEEA GDILLFLTGE DEIEDAVRKI SLEGDQLVRE  60
   61 EGCGPLSVYP LYGSLPPHQQ QRIFEPAPES HNGRPGRKVV ISTNIAETSL TIDGIVYVVD 120
  121 PGFSKQKVYN PRIRVESLLV SPISKASAQQ RAGRAGRTRP GKCFRLYTEE AFQKELIEQS 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.69897
Match: 1hv8A_
Description: Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [454-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPEILRSNLS STVLELKKLG IDDLVHFDFM DPPAPETMMR ALEELNYLAC LDDEGNLTPL  60
   61 GRLASQFPLD 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.23
Match: 1jr3D
Description: delta subunit; delta subunit of DNA polymerase III, N-domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [524-666]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PMLAVMLIGS FEFQCSQEIL TIVAMLSVPN VFIRPTKDKK RADDAKNIFA HPDGDHITLL  60
   61 NVYHAFKSDE AYEYGIHKWC RDHYLNYRSL SAADNIRSQL ERLMNRYNLE LNTTDYESPK 120
  121 YFDNIRKALA SGFFMQVAKK RSG

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.23
Match: 1jr3D
Description: delta subunit; delta subunit of DNA polymerase III, N-domain
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [667-767]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKGYITVKDN QDVLIHPSTV LGHDAEWVIY NEFVLTSKNY IRTVTSVRPE WLIEIAPAYY  60
   61 DLSNFQKGDV KLSLERIKEK VDRLNELKQG KNKKKSKHSK K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.548 0.044 mitochondrion a.118.8 TPR-like
View Download 0.569 0.013 pre-mRNA splicing factor activity a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.752 0.008 pre-mRNA splicing factor activity a.24.17 Group V grass pollen allergen
View Download 0.725 0.004 pre-mRNA splicing factor activity a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.534 N/A N/A a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.480 N/A N/A a.24.4 Hemerythrin
View Download 0.413 N/A N/A a.60.13 Putative methyltransferase TM0872, insert domain
View Download 0.401 N/A N/A d.15.4 2Fe-2S ferredoxin-like
View Download 0.394 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.384 N/A N/A a.2.3 Chaperone J-domain
View Download 0.363 N/A N/A a.25.1 Ferritin-like
View Download 0.354 N/A N/A a.74.1 Cyclin-like
View Download 0.344 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.335 N/A N/A d.15.1 Ubiquitin-like
View Download 0.313 N/A N/A d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.308 N/A N/A a.29.4 RecG, N-terminal domain
View Download 0.308 N/A N/A c.78.2 Aspartate/glutamate racemase
View Download 0.296 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.289 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.282 N/A N/A a.24.11 Bacterial GAP domain
View Download 0.278 N/A N/A a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.239 N/A N/A a.74.1 Cyclin-like
View Download 0.238 N/A N/A a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.237 N/A N/A b.82.4 Regulatory protein AraC
View Download 0.235 N/A N/A a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.233 N/A N/A a.24.3 Cytochromes
View Download 0.233 N/A N/A d.15.6 Superantigen toxins, C-terminal domain
View Download 0.229 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.228 N/A N/A d.58.9 RuBisCO, large subunit, small (N-terminal) domain
View Download 0.224 N/A N/A a.7.8 GAT domain
View Download 0.224 N/A N/A c.23.1 CheY-like
View Download 0.222 N/A N/A a.26.1 4-helical cytokines
View Download 0.220 N/A N/A d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.218 N/A N/A a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.218 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.208 N/A N/A a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.205 N/A N/A a.139.1 Type I dockerin domain
View Download 0.205 N/A N/A d.29.1 Ribosomal protein L31e
View Download 0.205 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle