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View Structure Prediction Details

Protein: PUS2
Organism: Saccharomyces cerevisiae
Length: 370 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PUS2.

Description E-value Query
Range
Subject
Range
PUS2 - Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; effi...
gi|6321375|ref|N... - Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; effi...
0.0 [1..370] [1..370]
gi|23308411, gi|... - gi|6573728|gb|AAF17648.1|AC009978_24 T23E18.5 [Arabidopsis thaliana], gi|23308411|gb|AAN18175.1| At1...
2.0E-85 [1..368] [26..435]
PUS2_SCHPO - tRNA pseudouridine synthase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pus2 PE=3 SV...
pus2 - tRNA pseudouridylate synthase Pus2
1.0E-75 [1..364] [43..440]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
6.0E-67 [2..346] [5..330]
gi|293415611|ref... - tRNA pseudouridine synthase A [Escherichia coli B185]
TRUA_ECOL6 - tRNA pseudouridine synthase A OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=truA...
gi|209764792, gi... - pir||C85873 pseudouridylate synthase I [imported] - Escherichia coli (strain O157:H7, substrain EDL...
gi|291283559|ref... - tRNA pseudouridine synthase A [Escherichia coli O55:H7 str. CB9615]
gi|12516677, gi|... - gi|15802865|ref|NP_288892.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 EDL933], gi|125...
gi|189362830, gi... - gi|189362830|gb|EDU81249.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. EC4486], gi...
TRUA_ECO57 - tRNA pseudouridine synthase A OS=Escherichia coli O157:H7 GN=truA PE=3 SV=1
gi|168761239, gi... - gi|189368293|gb|EDU86709.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. EC4501], gi...
TRUA_ECOL6 - tRNA pseudouridine synthase A OS=Escherichia coli O6 GN=truA PE=3 SV=1
gi|189357607, gi... - gi|189357607|gb|EDU76026.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. EC4401], gi...
gi|293410675|ref... - tRNA pseudouridine synthase A [Escherichia coli B354]
gi|261223227|ref... - tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. FRIK2000]
gi|188017261, gi... - gi|188017261|gb|EDU55383.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. EC4113], gi...
gi|168798493, gi... - gi|189378874|gb|EDU97290.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. EC508], gi|...
gi|168787230, gi... - gi|189372810|gb|EDU91226.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. EC869], gi|...
gi|168780178, gi... - gi|189001906|gb|EDU70892.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. EC4076], gi...
gi|187771144, gi... - gi|187771144|gb|EDU34988.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. EC4196], gi...
gi|293405784|ref... - tRNA pseudouridine synthase A [Escherichia coli FVEC1412]
gi|13362672, gi|... - gi|15832456|ref|NP_311229.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. Sakai], gi...
gi|261259223|ref... - tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. FRIK966]
TRUA_ECOLU - tRNA pseudouridine synthase A OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=truA PE=3 S...
TRUA_ECO7I - tRNA pseudouridine synthase A OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=truA PE=3 SV=1
gi|208811862, gi... - gi|208811862|ref|ZP_03253191.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. EC4045]...
gi|208727696, gi... - gi|208807895|ref|ZP_03250232.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. EC4206]...
gi|195935697 - gi|195935697|ref|ZP_03081079.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. EC4024]
TRUA_ECOSM - tRNA pseudouridine synthase A OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=truA PE=3 SV=1
TRUA_ECO55 - tRNA pseudouridine synthase A OS=Escherichia coli (strain 55989 / EAEC) GN=truA PE=3 SV=1
gi|217319539, gi... - gi|217327172|ref|ZP_03443255.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. TW14588...
TRUA_ECO5E - tRNA pseudouridine synthase A OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=truA PE=3 SV=1
gi|208741667, gi... - gi|208821544|ref|ZP_03261864.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. EC4042]...
gi|293446655|ref... - tRNA pseudouridine synthase A [Escherichia coli B088]
gi|254794211, gi... - gi|254794211|ref|YP_003079048.1| tRNA pseudouridine synthase A [Escherichia coli O157:H7 str. TW1435...
gi|227887378, gi... - gi|227887378|ref|ZP_04005183.1| tRNA pseudouridine synthase A [Escherichia coli 83972], gi|227835728...
TRUA_SHIDS - tRNA pseudouridine synthase A OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=truA PE=3 SV=1
3.0E-59 [1..215] [14..218]

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Predicted Domain #1
Region A:
Residues: [1-124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLGYCGSGY YGMQYNPPHK TIEGEILTKL FDVGAISEEN SLAPKKNSFM AAARTDKGVH  60
   61 AMLNLLSLKI TLREDTVAKL NAALPPEIRV WGIQPVNKKF NARSACDSRW YQYLIPEFIL 120
  121 IGPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 109.980454
Match: 1dj0A_
Description: Pseudouridine synthase I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
pseudouridine synthase activity 5.19957135839682 bayes_pls_golite062009
intramolecular transferase activity 3.78688422405974 bayes_pls_golite062009
isomerase activity 2.91720316078381 bayes_pls_golite062009
transcription regulator activity 2.31595692797262 bayes_pls_golite062009
catalytic activity 2.02180970970004 bayes_pls_golite062009
nucleic acid binding 2.01176877679953 bayes_pls_golite062009
DNA binding 1.95629441517514 bayes_pls_golite062009
binding 1.32358464424761 bayes_pls_golite062009
transcription activator activity 1.27357280497723 bayes_pls_golite062009
protein binding 1.10318302423731 bayes_pls_golite062009
RNA binding 0.706879359688019 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [125-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSSLLHRNVG GSYREDGSQE VWDTFLEQTR GRFSGDELCR LQDTAQKLSE SDPLVQDYVG  60
   61 LLSGTLSGYC LSPSKLDAFE AAMQEYVGTH N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 109.980454
Match: 1dj0A_
Description: Pseudouridine synthase I
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [216-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FHNFTTGKLW GDPSAQRHIK KVVVSQASPG WICVRIHGQS FMLHQIRRMV ALAVLAARCQ  60
   61 LPPNIVRNYF NAGPRKYIPR APAQGLLLEG PVFDGYNTKL RNLLYCEIRP DDITLERMCR 120
  121 FRERQICTAI AHEETQRHVF CHFVRQMNRL ATPLI

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 7.920819
Match: PF01416
Description: tRNA pseudouridine synthase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle