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View Structure Prediction Details

Protein: YFL052W
Organism: Saccharomyces cerevisiae
Length: 465 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YFL052W.

Description E-value Query
Range
Subject
Range
gi|3881 - gi|3881|emb|CAA33319.1| unnamed protein product [Saccharomyces cerevisiae]
gi|151946690 - gi|151946690|gb|EDN64911.1| MAL-activator protein [Saccharomyces cerevisiae YJM789]
0.0 [1..465] [1..470]
gi|171885|gb|AAA... - maltose activator protein (MAL63)
gi|171885 - gi|171885|gb|AAA34755.1| maltose activator protein (MAL63)
ID=asmbl_4865|m.3169 - ID=asmbl_4865|g.3169 ORF ID=asmbl_4865|g.3169 ID=asmbl_4865|m.3169 type:complete len:471 (+) ID=asm...
0.0 [1..465] [1..470]

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Predicted Domain #1
Region A:
Residues: [1-43]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARNRQACDC CCIRRVKCDR KKPCKCCLQH NLQCTYLRPL KKR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.221849
Match: 1d66A_
Description: Gal4; CD2-Gal4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.56444258780502 bayes_pls_golite062009
DNA binding 4.26146437716972 bayes_pls_golite062009
nucleic acid binding 4.17369933547911 bayes_pls_golite062009
transcription factor activity 3.049435548132 bayes_pls_golite062009
binding 2.91929847152301 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.03201524223606 bayes_pls_golite062009
sequence-specific DNA binding 1.87955444697212 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.86200506906385 bayes_pls_golite062009
transcription activator activity 0.915626626047549 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [44-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPKPVKVRNL KKVDDVQVFS KSSSGGIMKV PKALIDQCLR LYNDKLYVIW PLLCYDDLYE  60
   61 LLEKRYDETC VYWFLVSLSA ATLSDLQTEI ESEGGVTFTG IQLSSFCMSS RQEFDDFNGS 120
  121 DIFKIMTYYC LNRCYAQMSN SRTSYRLSCE AVGLIKLAGF HREETLKLLP FDEQQLGRKV 180
  181 YYLLLLTERY FSVYTHCATS LDTTIAPPQP ENVTDPRLSL DSFLEMIRVF TVPGKCFFDA 240
  241 LATDSANVTC TEDSLKKIWR ELHTVPLEIE PWSYGYVDIS FSRHWIRTLA WKLVLQISGM 300
  301 RISFLSN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [351-465]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKNTHIPVEI ARDMLEDTFL IPKNLYAVHG PGISVKALEI ADALVDVVNQ YDQNAESEAW  60
   61 NFLFDISKFV FSLKHCDSTL VDKFTTKCQC ALITLPLSNP LESTDGSKED VDALP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.677 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.555 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.584 a.24.4 Hemerythrin
View Download 0.745 e.20.1 Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
View Download 0.586 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.489 e.20.1 Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
View Download 0.457 a.24.17 Group V grass pollen allergen
View Download 0.446 a.64.1 Saposin
View Download 0.445 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.437 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.431 a.24.4 Hemerythrin
View Download 0.415 a.24.3 Cytochromes
View Download 0.405 a.24.17 Group V grass pollen allergen
View Download 0.398 a.29.4 RecG, N-terminal domain
View Download 0.395 e.20.1 Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
View Download 0.373 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.370 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.369 a.24.4 Hemerythrin
View Download 0.366 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.359 a.4.1 Homeodomain-like
View Download 0.358 a.24.4 Hemerythrin
View Download 0.350 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.346 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.340 a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.334 a.64.1 Saposin
View Download 0.334 a.118.8 TPR-like
View Download 0.333 a.24.17 Group V grass pollen allergen
View Download 0.324 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.305 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.300 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.289 a.29.4 RecG, N-terminal domain
View Download 0.287 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.284 a.29.4 RecG, N-terminal domain
View Download 0.272 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.271 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.268 a.24.17 Group V grass pollen allergen
View Download 0.267 a.29.4 RecG, N-terminal domain
View Download 0.267 d.58.26 GHMP Kinase, C-terminal domain
View Download 0.266 c.78.2 Aspartate/glutamate racemase
View Download 0.266 a.81.1 N-terminal domain of DnaB helicase
View Download 0.266 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.265 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.264 a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.263 a.29.4 RecG, N-terminal domain
View Download 0.263 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.259 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.258 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.254 e.20.1 Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
View Download 0.254 a.24.17 Group V grass pollen allergen
View Download 0.254 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.245 a.24.17 Group V grass pollen allergen
View Download 0.240 a.4.1 Homeodomain-like
View Download 0.239 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.238 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.238 d.58.26 GHMP Kinase, C-terminal domain
View Download 0.237 a.29.4 RecG, N-terminal domain
View Download 0.236 a.24.4 Hemerythrin
View Download 0.236 a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.236 a.24.4 Hemerythrin
View Download 0.235 c.78.2 Aspartate/glutamate racemase
View Download 0.234 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.230 a.141.1 Frizzled cystein-rich domain
View Download 0.228 a.156.1 S13-like H2TH domain
View Download 0.227 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.224 a.118.8 TPR-like
View Download 0.223 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.223 d.8.1 Urease, gamma-subunit
View Download 0.223 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.221 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.219 a.24.11 Bacterial GAP domain
View Download 0.218 i.11.1 Computational models partly based on NMR data
View Download 0.213 a.24.3 Cytochromes
View Download 0.212 a.24.17 Group V grass pollen allergen
View Download 0.210 a.26.1 4-helical cytokines
View Download 0.210 a.24.4 Hemerythrin
View Download 0.210 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.209 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.207 a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.201 a.24.4 Hemerythrin
View Download 0.201 a.74.1 Cyclin-like

Predicted Domain #4
Region A:
Residues: [315-465]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WSYGYVDISF SRHWIRTLAW KLVLQISGMR ISFLSNSKNT HIPVEIARDM LEDTFLIPKN  60
   61 LYAVHGPGIS VKALEIADAL VDVVNQYDQN AESEAWNFLF DISKFVFSLK HCDSTLVDKF 120
  121 TTKCQCALIT LPLSNPLEST DGSKEDVDAL P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.745 e.20.1 Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
View Download 0.677 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.586 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.584 a.24.4 Hemerythrin
View Download 0.555 a.24.13 Domain of the SRP/SRP receptor G-proteins


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle