YRC Public Data Repository - Protein Structure Prediction

Protein:	PRB1
Organism:	Saccharomyces cerevisiae
Length:	635 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRB1.

Description	E-value	Query Range	Subject Range
PRTB_YEAST - Cerevisin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRB1 PE=1 SV=1 PRB1 - Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degrad...	0.0	[1..635]	[1..635]
ALP2_ASPFC - Alkaline protease 2 OS=Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) GN=alp2 PE=3 SV... gi\|2143220, gi\|5... - gi\|5139328\|emb\|CAB45520.1\| serine proteinase [Aspergillus fumigatus], gi\|2143220\|emb\|CAA73782.1\| cel... ALP2_ASPFU - Alkaline protease 2 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)...	0.0	[137..635]	[1..485]
gi\|17385556 - gi\|17385556\|emb\|CAC85639.1\| serine protease 2 [Pyrenopeziza brassicae]	0.0	[137..626]	[1..482]
gi\|171680111 - gi\|171680111\|ref\|XP_001905001.1\| unnamed protein product [Podospora anserina] gi\|7400480, gi\|1... - gi\|7400480\|gb\|AAC03564.2\| subtilisin-like serine protease [Podospora anserina], gi\|170939682\|emb\|CAP...	0.0	[137..630]	[1..487]
gi\|6624950 - gi\|6624950\|emb\|CAB63907.1\| Subtilisin-like protease PR1H [Metarhizium anisopliae var. anisopliae] gi\|6624950 - gi\|6624950\|emb\|CAB63907.1\| Subtilisin-like protease PR1H [Metarhizium anisopliae var. anisopliae]	0.0	[147..631]	[2..522]
gi\|15808807 - gi\|15808807\|gb\|AAL08510.1\|AF413106_1 subtilase [Ophiostoma piliferum]	0.0	[141..587]	[2..445]
gi\|7963902 - gi\|7963902\|gb\|AAF71379.1\|AF264027_1 allergen Pen n 18 [Penicillium chrysogenum]	0.0	[137..635]	[1..484]
gi\|16215673 - gi\|16215673\|emb\|CAC95047.1\| subtilisin-like serine protease PR1H [Metarhizium anisopliae var. acridu...	0.0	[147..633]	[2..506]

Back

Predicted Domain #1

Region A:
Residues: [1-111]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLENTLFTL GALGSISAAL VIPNLENAAD HHELINKEDH HERPRKVEFT KDDDEEPSDS  60
   61 EDKEHGKFHK KGRKGQDKES PEFNGKRASG SHGSAHEGGK GMKPKHESSN D

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [112-282]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDNDDKKKKP HHKGGCHENK VEEKKMKGKK VKGKKHHEKT LEKGRHHNRL APLVSTAQFN  60
   61 PDAISKIIPN RYIIVFKRGA PQEEIDFHKE NVQQAQLQSV ENLSAEDAFF ISTKDTSLST 120
  121 SEAGGIQDSF NIDNLFSGYI GYFTQEIVDL IRQNPLVDFV ERDSIVEATE F

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.0
Match:	1scjB_
Description:	Subtilisin prosegment
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [283-635]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTQNSAPWGL ARISHRERLN LGSFNKYLYD DDAGRGVTSY VIDTGVNINH KDFEKRAIWG  60
   61 KTIPLNDEDL DGNGHGTHCA GTIASKHYGV AKNANVVAVK VLRSNGSGTM SDVVKGVEYA 120
  121 AKAHQKEAQE KKKGFKGSTA NMSLGGGKSP ALDLAVNAAV EVGIHFAVAA GNENQDACNT 180
  181 SPASADKAIT VGASTLSDDR AYFSNWGKCV DVFAPGLNIL STYIGSDDAT ATLSGTSMAS 240
  241 PHVAGLLTYF LSLQPGSDSE FFELGQDSLT PQQLKKKLIH YSTKDILFDI PEDTPNVLIY 300
  301 NGGGQDLSAF WNDTKKSHSS GFKQELNMDE FIGSKTDLIF DQVRDILDKL NII

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	630.917458
Match:	1ic6A_
Description:	Proteinase K
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	4.68838733699853	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	4.20928698248021	bayes_pls_golite062009
endopeptidase activity	3.45296270246929	bayes_pls_golite062009
hydrolase activity	3.36483239319728	bayes_pls_golite062009
serine hydrolase activity	1.90036575189745	bayes_pls_golite062009
serine-type peptidase activity	1.89198766955068	bayes_pls_golite062009
binding	1.85875472341221	bayes_pls_golite062009
serine-type endopeptidase activity	1.23150012549143	bayes_pls_golite062009
catalytic activity	0.597535457699629	bayes_pls_golite062009
protein binding	0.380935140681308	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: