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View Structure Prediction Details

Protein: PAC11
Organism: Saccharomyces cerevisiae
Length: 533 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PAC11.

Description E-value Query
Range		 Subject
Range
PAC11 - Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microt...
PAC11_YEAST - WD repeat-containing protein PAC11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAC11...
 0.0 [1..533] [1..533]
HETE1_PODAS - Vegetative incompatibility protein HET-E-1 OS=Podospora anserina GN=HET-E1 PE=3 SV=1
 5.0E-82 [161..528] [879..1247]
gi|17232326, gi|... - gi|17232326|ref|NP_488874.1| WD repeat-containing protein [Nostoc sp. PCC 7120], gi|17133971|dbj|BAB...
gi|25530232 - pir||AB2410 WD-repeat protein [imported] - Nostoc sp. (strain PCC 7120)
 3.0E-81 [2..530] [836..1311]
gi|207113124, gi... - gi|4633650|gb|AAD26852.1|AF123074_2 cytoplasmic dynein intermediate chain 1 [Homo sapiens], gi|20711...
gi|114614624 - gi|114614624|ref|XP_001170561.1| PREDICTED: dynein, cytoplasmic, intermediate polypeptide 1 isoform ...
 8.0E-79 [4..527] [39..566]
gi|3493589 - gi|3493589|gb|AAC33445.1| cytoplasmic dynein intermediate chain 1B [Mus musculus]
 2.0E-75 [4..527] [39..566]

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Predicted Domain #1
Region A:
Residues: [1-140] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERLKQLEEK RRQLKELRER RKQASLFPGS ETMGHHPTEV HAKATMVSVS VQTDMEEGSK  60
   61 IQEPQSAYLR RKEVITYDKG IQTDQIEEEQ LQENENHTTT DAVAIETTAA DENNKDKAEN 120
  121 DQPRLELAKP FLVEEAAATL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.232 0.979 microtubule motor activity c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.463 0.006 microtubule motor activity a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.241 N/A N/A a.121.1 Tetracyclin repressor-like, C-terminal domain

Predicted Domain #2
Region A:
Residues: [141-533] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNASFARLET EVSASGQQAP SNMQQDKDNL MQWNMVSENL QSETDCDCIA QEYDPGKGVL  60
   61 VVVYLRLPPA DLQYASSEAA WSVVNVVKCD NASGRNGLLI DMVEFRGTRI MTATILRRYH 120
  121 PESNVISILL ATLTGKIILY ELRLKQKKPE TPVVYVVQRN MVARHYFQHP VVAVIETSSV 180
  181 QDQERVLVAA DNGNIMELSC LDLTVLRKPQ QLRPVPLSQL LSLENDTCTY TERLQRLAKF 240
  241 DEVGIACMAY TSEDPQYVWI GGEDGGIYKV FWDQPGPLYL SLDNNGFQPA ENHSTRVTGL 300
  301 EFHWDDARRL MLLLSCSTDW TVRLWDARAG KAIIGAPLLL GGPVLRARWL EKNNGGENSR 360
  361 TLRCQVWCAD GRLVVVNWAF DAKTSLYTAT VIS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.69897
Match: 1erjA_
Description: Tup1, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
tubulin binding 2.76945430061825 bayes_pls_golite062009
microtubule binding 2.72684103222924 bayes_pls_golite062009
binding 2.56763106794721 bayes_pls_golite062009
dynein binding 1.73730057055973 bayes_pls_golite062009
cytoskeletal protein binding 1.6857070194499 bayes_pls_golite062009
protein binding 1.11897341394404 bayes_pls_golite062009
dynactin binding 1.09205354470481 bayes_pls_golite062009
transcription repressor activity 1.05679861435905 bayes_pls_golite062009
microtubule plus-end binding 1.01166033978052 bayes_pls_golite062009
transcription regulator activity 0.831480546979987 bayes_pls_golite062009
myosin binding 0.79466819364522 bayes_pls_golite062009
transporter activity 0.692270256454453 bayes_pls_golite062009
nucleic acid binding 0.626057815566445 bayes_pls_golite062009
dynein intermediate chain binding 0.443846546939402 bayes_pls_golite062009
DNA polymerase activity 0.428715007921149 bayes_pls_golite062009
DNA binding 0.387799300258449 bayes_pls_golite062009
transcription corepressor activity 0.375646066797591 bayes_pls_golite062009
structural constituent of cytoskeleton 0.136160694936939 bayes_pls_golite062009
substrate-specific transporter activity 0.121183207943714 bayes_pls_golite062009
actin binding 0.120045107841246 bayes_pls_golite062009
structural molecule activity 0.0588151480189092 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00585398682921312 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [467-533] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARAGKAIIGA PLLLGGPVLR ARWLEKNNGG ENSRTLRCQV WCADGRLVVV NWAFDAKTSL  60
   61 YTATVIS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.69897
Match: 1nexB
Description: Cdc4 F-box and linker domains; Cdc4 propeller domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle