YRC Public Data Repository - Protein Structure Prediction

Protein:	DOT1
Organism:	Saccharomyces cerevisiae
Length:	582 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DOT1.

Description	E-value	Query Range	Subject Range
DOT1 - Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic che... DOT1_YEAST - Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Saccharomyces cerevisiae (strain ATCC 2...	0.0	[1..582]	[1..582]
gi\|2995577 - gi\|2995577\|gb\|AAC08316.1\| R29381_1 [Homo sapiens]	3.0E-62	[293..580]	[6..300]
gi\|11277873 - pir\|\|A81324 cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) Cj1183c [similarity] - Campy... gi\|15792507, gi\|... - gi\|6968616\|emb\|CAB73437.1\| putative cyclopropane-fatty-acyl-phospholipid synthase [Campylobacter jej...	7.0E-49	[247..569]	[25..345]
gi\|15894164, gi\|... - gi\|15894164\|ref\|NP_347513.1\| cyclopropane fatty acid synthase [Clostridium acetobutylicum ATCC 824],... gi\|25300077 - pir\|\|B97008 cyclopropane fatty acid synthase [imported] - Clostridium acetobutylicum	7.0E-45	[249..507]	[30..270]
CE03424 - status:Partially_confirmed UniProt:Q20856 protein_id:CAA90610.1	7.0E-44	[344..579]	[129..365]
gi\|7443722 - pir\|\|H64571 cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) - Helicobacter pylori (strai... gi\|2313520, gi\|1... - gi\|2313520\|gb\|AAD07482.1\| cyclopropane fatty acid synthase (cfa) [Helicobacter pylori 26695], gi\|156...	5.0E-37	[267..569]	[47..347]
gi\|13492588 - gi\|13492588\|gb\|AAK28284.1\| unknown [Leishmania major]	1.0E-36	[341..552]	[152..358]
gi\|7443721 - pir\|\|B71865 cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) - Helicobacter pylori (strai... gi\|4155557, gi\|1... - gi\|4155557\|gb\|AAD06552.1\| CYCLOPOCYCLOPROPANE FATTY ACID SYNTHASE [Helicobacter pylori J99], gi\|1561...	4.0E-36	[267..532]	[47..301]

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Predicted Domain #1

Region A:
Residues: [1-174]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGQESISNN NSDSFIMSSP NLDSQESSIS PIDEKKGTDM QTKSLSSYSK GTLLSKQVQN  60
   61 LLEEANKYDP IYGSSLPRGF LRDRNTKGKD NGLVPLVEKV IPPIHKKTNN RNTRKKSSTT 120
  121 TKKDVKKPKA AKVKGKNGRT NHKHTPISKQ EIDTAREKKP LKKGRANKKN DRDS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [175-327]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSSTFVDWNG PCLRLQYPLF DIEYLRSHEI YSGTPIQSIS LRTNSPQPTS LTSDNDTSSV  60
   61 TTAKLQSILF SNYMEEYKVD FKRSTAIYNP MSEIGKLIEY SCLVFLPSPY AEQLKETILP 120
  121 DLNASFDNSD TKGFVNAINL YNKMIREIPR QRI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
protein methyltransferase activity	5.03267617653315	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	4.4632173842967	bayes_pls_golite062009
histone methyltransferase activity	4.40911163698179	bayes_pls_golite062009
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
N-methyltransferase activity	4.07806017452628	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	3.26663548517117	bayes_pls_golite062009
arginine N-methyltransferase activity	3.26663548517117	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	2.86617323549909	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	2.48017990451667	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	2.25250509433971	bayes_pls_golite062009
transferase activity	2.22303238506686	bayes_pls_golite062009
DNA-methyltransferase activity	2.18991764495147	bayes_pls_golite062009
transcription regulator activity	2.0187748912503	bayes_pls_golite062009
rRNA methyltransferase activity	1.93505048403302	bayes_pls_golite062009
DNA binding	1.86585662505513	bayes_pls_golite062009
nucleic acid binding	1.71901340148111	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	1.69391860928068	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
binding	0.976078016260105	bayes_pls_golite062009
histone binding	0.964746527369069	bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity	0.865238728135767	bayes_pls_golite062009
lysine N-methyltransferase activity	0.858129308056814	bayes_pls_golite062009
protein-lysine N-methyltransferase activity	0.858129308056814	bayes_pls_golite062009
histone-lysine N-methyltransferase activity	0.858129308056814	bayes_pls_golite062009
RNA methyltransferase activity	0.817509452491588	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	0.229189844833659	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	0.152064081957651	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [328-391]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDHLETIDKI PRSFIHDFLH IVYTRSIHPQ ANKLKHYKAF SNYVYGELLP NFLSDVYQQC  60
   61 QLKK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [392-511]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDTFMDLGSG VGNCVVQAAL ECGCALSFGC EIMDDASDLT ILQYEELKKR CKLYGMRLNN  60
   61 VEFSLKKSFV DNNRVAELIP QCDVILVNNF LFDEDLNKKV EKILQTAKVG CKIISLKSLR 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	680.211549
Match:	1m0rA_
Description:	No description for 1m0rA_ was found.

Predicted Domain #5

Region A:
Residues: [512-582]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLTYQINFYN VENIFNRLKV QRYDLKEDSV SWTHSGGEYY ISTVMEDVDE SLFSPAARGR  60
   61 RNRGTPVKYT R

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: