| Protein: | DOT1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 582 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DOT1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..582] | [1..582] |
|
|
3.0E-62 | [293..580] | [6..300] |
|
|
7.0E-49 | [247..569] | [25..345] |
|
|
7.0E-45 | [249..507] | [30..270] |
|
|
7.0E-44 | [344..579] | [129..365] |
|
|
5.0E-37 | [267..569] | [47..347] |
|
|
1.0E-36 | [341..552] | [152..358] |
|
|
4.0E-36 | [267..532] | [47..301] |
|
Region A: Residues: [1-174] |
1 11 21 31 41 51
| | | | | |
1 MGGQESISNN NSDSFIMSSP NLDSQESSIS PIDEKKGTDM QTKSLSSYSK GTLLSKQVQN 60
61 LLEEANKYDP IYGSSLPRGF LRDRNTKGKD NGLVPLVEKV IPPIHKKTNN RNTRKKSSTT 120
121 TKKDVKKPKA AKVKGKNGRT NHKHTPISKQ EIDTAREKKP LKKGRANKKN DRDS
|
| Detection Method: |  |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [175-327] |
1 11 21 31 41 51
| | | | | |
1 PSSTFVDWNG PCLRLQYPLF DIEYLRSHEI YSGTPIQSIS LRTNSPQPTS LTSDNDTSSV 60
61 TTAKLQSILF SNYMEEYKVD FKRSTAIYNP MSEIGKLIEY SCLVFLPSPY AEQLKETILP 120
121 DLNASFDNSD TKGFVNAINL YNKMIREIPR QRI
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.286 | 0.289 | histone methylation | b.40.4 | Nucleic acid-binding proteins |
| View | Download | 0.278 | 0.094 | histone methylation | a.118.1 | ARM repeat |
| View | Download | 0.350 | 0.091 | histone methylation | b.2.5 | p53-like transcription factors |
| View | Download | 0.424 | 0.077 | histone methylation | a.118.8 | TPR-like |
| View | Download | 0.286 | 0.011 | histone methylation | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.225 | N/A | N/A | a.25.1 | Ferritin-like |
| View | Download | 0.219 | N/A | N/A | a.149.1 | RNase III endonuclease catalytic domain |
| Term | Confidence | Notes |
| protein methyltransferase activity | 5.03267617653315 | bayes_pls_golite062009 |
| S-adenosylmethionine-dependent methyltransferase activity | 4.4632173842967 | bayes_pls_golite062009 |
| histone methyltransferase activity | 4.40911163698179 | bayes_pls_golite062009 |
| methyltransferase activity | 4.15445027778357 | bayes_pls_golite062009 |
| N-methyltransferase activity | 4.07806017452628 | bayes_pls_golite062009 |
| transferase activity, transferring one-carbon groups | 4.07153733729662 | bayes_pls_golite062009 |
| protein-arginine N-methyltransferase activity | 3.26663548517117 | bayes_pls_golite062009 |
| arginine N-methyltransferase activity | 3.26663548517117 | bayes_pls_golite062009 |
| histone-arginine N-methyltransferase activity | 2.86617323549909 | bayes_pls_golite062009 |
| protein-arginine omega-N monomethyltransferase activity | 2.48017990451667 | bayes_pls_golite062009 |
| histone methyltransferase activity (H4-R3 specific) | 2.25250509433971 | bayes_pls_golite062009 |
| transferase activity | 2.22303238506686 | bayes_pls_golite062009 |
| DNA-methyltransferase activity | 2.18991764495147 | bayes_pls_golite062009 |
| transcription regulator activity | 2.0187748912503 | bayes_pls_golite062009 |
| rRNA methyltransferase activity | 1.93505048403302 | bayes_pls_golite062009 |
| DNA binding | 1.86585662505513 | bayes_pls_golite062009 |
| nucleic acid binding | 1.71901340148111 | bayes_pls_golite062009 |
| protein-arginine omega-N asymmetric methyltransferase activity | 1.69391860928068 | bayes_pls_golite062009 |
| catalytic activity | 1.25333584501255 | bayes_pls_golite062009 |
| binding | 0.976078016260105 | bayes_pls_golite062009 |
| histone binding | 0.964746527369069 | bayes_pls_golite062009 |
| protein-arginine omega-N symmetric methyltransferase activity | 0.865238728135767 | bayes_pls_golite062009 |
| lysine N-methyltransferase activity | 0.858129308056814 | bayes_pls_golite062009 |
| protein-lysine N-methyltransferase activity | 0.858129308056814 | bayes_pls_golite062009 |
| histone-lysine N-methyltransferase activity | 0.858129308056814 | bayes_pls_golite062009 |
| RNA methyltransferase activity | 0.817509452491588 | bayes_pls_golite062009 |
| site-specific DNA-methyltransferase (adenine-specific) activity | 0.703178429468566 | bayes_pls_golite062009 |
| rRNA (adenine) methyltransferase activity | 0.229189844833659 | bayes_pls_golite062009 |
| rRNA (adenine-N6,N6-)-dimethyltransferase activity | 0.152064081957651 | bayes_pls_golite062009 |
|
Region A: Residues: [328-391] |
1 11 21 31 41 51
| | | | | |
1 IDHLETIDKI PRSFIHDFLH IVYTRSIHPQ ANKLKHYKAF SNYVYGELLP NFLSDVYQQC 60
61 QLKK
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [392-511] |
1 11 21 31 41 51
| | | | | |
1 GDTFMDLGSG VGNCVVQAAL ECGCALSFGC EIMDDASDLT ILQYEELKKR CKLYGMRLNN 60
61 VEFSLKKSFV DNNRVAELIP QCDVILVNNF LFDEDLNKKV EKILQTAKVG CKIISLKSLR 120
121
|
| Detection Method: | |
| Confidence: | 680.211549 |
| Match: | 1m0rA_ |
| Description: | No description for 1m0rA_ was found. |
|
Region A: Residues: [512-582] |
1 11 21 31 41 51
| | | | | |
1 SLTYQINFYN VENIFNRLKV QRYDLKEDSV SWTHSGGEYY ISTVMEDVDE SLFSPAARGR 60
61 RNRGTPVKYT R
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.559 | d.58.1 | 4Fe-4S ferredoxins |
| View | Download | 0.686 | d.58.17 | Metal-binding domain |
| View | Download | 0.572 | d.52.1 | Alpha-lytic protease prodomain |
| View | Download | 0.681 | d.58.24 | CheY-binding domain of CheA |
| View | Download | 0.619 | d.58.17 | Metal-binding domain |
| View | Download | 0.534 | d.58.10 | Acylphosphatase-like |
| View | Download | 0.523 | d.58.18 | Regulatory domain in the aminoacid metabolism |
| View | Download | 0.513 | d.58.3 | Protease propeptides/inhibitors |
| View | Download | 0.472 | d.58.18 | Regulatory domain in the aminoacid metabolism |
| View | Download | 0.453 | d.58.17 | Metal-binding domain |
| View | Download | 0.446 | d.50.3 | PI-Pfui intein middle domain |
| View | Download | 0.422 | d.58.10 | Acylphosphatase-like |
| View | Download | 0.401 | d.58.17 | Metal-binding domain |
| View | Download | 0.397 | d.58.10 | Acylphosphatase-like |
| View | Download | 0.397 | d.58.11 | EF-G/eEF-2 domains III and V |
| View | Download | 0.394 | d.141.1 | Ribosomal protein L6 |
| View | Download | 0.385 | d.58.2 | Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain |
| View | Download | 0.382 | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.381 | d.58.10 | Acylphosphatase-like |
| View | Download | 0.374 | g.44.1 | RING/U-box |
| View | Download | 0.365 | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.365 | a.65.1 | Annexin |
| View | Download | 0.362 | d.58.5 | GlnB-like |
| View | Download | 0.354 | d.58.3 | Protease propeptides/inhibitors |
| View | Download | 0.353 | d.58.10 | Acylphosphatase-like |
| View | Download | 0.334 | d.58.49 | YajQ-like |
| View | Download | 0.331 | d.58.38 | Urease metallochaperone UreE, C-terminal domain |
| View | Download | 0.325 | a.28.3 | Retrovirus capsid protein C-terminal domain |
| View | Download | 0.323 | d.50.3 | PI-Pfui intein middle domain |
| View | Download | 0.323 | a.6.1 | Putative DNA-binding domain |
| View | Download | 0.315 | b.84.1 | Single hybrid motif |
| View | Download | 0.315 | d.58.17 | Metal-binding domain |
| View | Download | 0.311 | d.50.3 | PI-Pfui intein middle domain |
| View | Download | 0.300 | d.58.1 | 4Fe-4S ferredoxins |
| View | Download | 0.299 | d.58.10 | Acylphosphatase-like |
| View | Download | 0.297 | a.163.1 | Crustacean CHH/MIH/GIH neurohormone |
| View | Download | 0.281 | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.277 | d.58.11 | EF-G/eEF-2 domains III and V |
| View | Download | 0.275 | a.6.1 | Putative DNA-binding domain |
| View | Download | 0.270 | d.58.10 | Acylphosphatase-like |
| View | Download | 0.256 | a.163.1 | Crustacean CHH/MIH/GIH neurohormone |
| View | Download | 0.241 | b.61.3 | D-aminopeptidase, middle and C-terminal domains |
| View | Download | 0.241 | d.19.1 | MHC antigen-recognition domain |
| View | Download | 0.240 | d.58.1 | 4Fe-4S ferredoxins |
| View | Download | 0.238 | d.58.1 | 4Fe-4S ferredoxins |
| View | Download | 0.236 | b.71.1 | Glycosyl hydrolase domain |
| View | Download | 0.235 | g.3.11 | EGF/Laminin |
| View | Download | 0.234 | a.77.1 | DEATH domain |
| View | Download | 0.229 | d.58.4 | Dimeric alpha+beta barrel |
| View | Download | 0.223 | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.219 | a.35.1 | lambda repressor-like DNA-binding domains |
