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View Structure Prediction Details

Protein: UBX5
Organism: Saccharomyces cerevisiae
Length: 500 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBX5.

Description E-value Query
Range
Subject
Range
UBX5 - UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
UBX5_YEAST - UBX domain-containing protein 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBX5 PE=...
gi|207346433 - gi|207346433|gb|EDZ72926.1| YDR330Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|151942306 - gi|151942306|gb|EDN60662.1| ubiquitin regulatory X [Saccharomyces cerevisiae YJM789]
gi|190404729 - gi|190404729|gb|EDV07996.1| UBX domain-containing protein 5 [Saccharomyces cerevisiae RM11-1a]
0.0 [1..500] [1..500]
gi|7527718, gi|2... - gi|7527718|gb|AAF63167.1|AC010657_3 T5E21.7 [Arabidopsis thaliana], pir||D86280 protein T5E21.7 [imp...
0.0 [5..488] [10..507]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [4..495] [6..465]
gi|19528655 - gi|19528655|ref|NP_572051.1| FAS-associated factor 1 isoform b [Homo sapiens]
1.0E-94 [3..497] [8..498]

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Predicted Domain #1
Region A:
Residues: [1-202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEGKVDEFM AITGADDAAI ATQFIEMADG NLNTAISLFF ENGGAALLSS NNTPTPSNST  60
   61 PMAPTSVDSD ADAQLAERLQ REAYQQQQPD QDYVRPPDEA RHEVLTETSG FPISYGGIGG 120
  121 RFEPLHRVND MFDEGRPESI FNQRLDDTNT NTYINDNSSD SLDSEEENDD DEYEYVEEPV 180
  181 IELDEDGNIK EYTKLVRKPK TI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [203-354]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKEQKLALLF RPPFSIMSKL DLDAAKQKAR AKQKWIMINI QDSGIFQCQA LNRDLWSSRP  60
   61 VKTIIKENFV FLQYQYESRN AQPYLQFYHL NNKDDLPHIA ILDPITGERV KQWNRVVPIP 120
  121 EQFISEINEF LASFSLDPKV PNPTVNEPLP KV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [355-500]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPTTLTEEQQ MELAIKESLN NNSSKSNQEE VPSTGEEQKR VQEPDPFSTI EARVHPEPPN  60
   61 KPGITTRIQI RTGDGSRLVR RFNALEDTVR TIYEVIKTEM DGFADSRFTL NDHQREDLID 120
  121 KLNMTIADAG LKNSSLLLEK LDPEIE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.221849
Match: 1jruA_
Description: p47
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.672192331361968 bayes_pls_golite062009
binding 0.665189138843282 bayes_pls_golite062009
hydrolase activity 0.150237022038507 bayes_pls_golite062009
transcription regulator activity 0.13699526678272 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [383-500]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEVPSTGEEQ KRVQEPDPFS TIEARVHPEP PNKPGITTRI QIRTGDGSRL VRRFNALEDT  60
   61 VRTIYEVIKT EMDGFADSRF TLNDHQREDL IDKLNMTIAD AGLKNSSLLL EKLDPEIE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.39794
Match: 1s3sG
Description: Crystal structure of AAA ATPase p97/VCP ND1 in complex with p47 C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.19381585790185 bayes_pls_golite062009
small conjugating protein ligase activity 1.83465130904364 bayes_pls_golite062009
protein binding 1.17197911794381 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.16468510691469 bayes_pls_golite062009
acid-amino acid ligase activity 0.919595189902044 bayes_pls_golite062009
nucleic acid binding 0.383121378043805 bayes_pls_golite062009
hydrolase activity 0.247201449341942 bayes_pls_golite062009
DNA binding 0.0840213088061073 bayes_pls_golite062009
transcription regulator activity 0.0485636215870291 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle