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View Structure Prediction Details

Protein: PCF11
Organism: Saccharomyces cerevisiae
Length: 626 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PCF11.

Description E-value Query
Range
Subject
Range
PCF11 - mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA)...
PCF11_YEAST - Protein PCF11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PCF11 PE=1 SV=2
0.0 [1..626] [1..626]
YD14_SCHPO - Uncharacterized protein C4G9.04c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC4G9.0...
SPAC4G9.04c - cleavage and polyadenylation specificity factor
0.0 [11..620] [7..575]
PCFS1_ARATH - Polyadenylation and cleavage factor homolog 1 OS=Arabidopsis thaliana GN=PCFS1 PE=1 SV=1
6.0E-86 [224..605] [36..392]
gi|18642418 - gi|18642418|emb|CAC81237.1| putative PCF11 protein [Brassica napus]
3.0E-85 [236..609] [38..365]
gi|13435542 - gi|13435542|gb|AAH04648.1| Pcf11 protein [Mus musculus]
1.0E-83 [153..618] [61..488]
gi|6069478 - gi|6069478|dbj|BAA85453.1| S-locus protein 4 [Brassica rapa]
4.0E-81 [236..609] [38..401]
PCF11 - PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)
3.0E-78 [153..618] [1157..1596]

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Predicted Domain #1
Region A:
Residues: [1-117]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHDTEVIVK DFNSILEELT FNSRPIITTL TKLAEENISC AQYFVDAIES RIEKCMPKQK  60
   61 LYAFYALDSI CKNVGSPYTI YFSRNLFNLY KRTYLLVDNT TRTKLINMFK LWLNPND

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.578 0.238 mRNA cleavage a.25.1 Ferritin-like
View Download 0.666 0.039 mRNA cleavage a.7.8 GAT domain
View Download 0.644 0.023 mRNA cleavage a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.533 0.006 mRNA cleavage d.164.1 SMAD MH1 domain
View Download 0.595 N/A N/A f.35.1 Multidrug efflux transporter AcrB transmembrane domain
View Download 0.525 N/A N/A a.1.1 Globin-like
View Download 0.515 N/A N/A a.118.8 TPR-like
View Download 0.502 N/A N/A d.65.1 Hedgehog/DD-pepidase
View Download 0.488 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.483 N/A N/A a.90.1 Transcription factor STAT-4 N-domain
View Download 0.474 N/A N/A a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.469 N/A N/A f.1.1 Colicin
View Download 0.467 N/A N/A a.25.1 Ferritin-like
View Download 0.458 N/A N/A a.22.1 Histone-fold
View Download 0.457 N/A N/A a.19.1 Fertilization protein
View Download 0.452 N/A N/A a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.452 N/A N/A d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.448 N/A N/A a.149.1 RNase III endonuclease catalytic domain
View Download 0.447 N/A N/A c.92.2 "Helical backbone" metal receptor
View Download 0.442 N/A N/A a.29.4 RecG, N-terminal domain
View Download 0.434 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.426 N/A N/A c.12.1 Ribosomal proteins L15p and L18e
View Download 0.415 N/A N/A a.22.1 Histone-fold
View Download 0.395 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.371 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.365 N/A N/A a.25.1 Ferritin-like
View Download 0.354 N/A N/A a.61.1 Retroviral matrix proteins
View Download 0.351 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.350 N/A N/A a.22.1 Histone-fold
View Download 0.348 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.340 N/A N/A a.118.11 Cytochrome c oxidase subunit E
View Download 0.338 N/A N/A a.49.1 C-terminal domain of B transposition protein
View Download 0.337 N/A N/A a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.334 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.334 N/A N/A a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.328 N/A N/A a.26.1 4-helical cytokines
View Download 0.317 N/A N/A d.189.1 PX domain
View Download 0.314 N/A N/A d.79.1 YjgF-like
View Download 0.309 N/A N/A a.22.1 Histone-fold
View Download 0.297 N/A N/A d.110.4 SNARE-like
View Download 0.291 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.286 N/A N/A a.26.1 4-helical cytokines
View Download 0.286 N/A N/A a.72.1 Functional domain of the splicing factor Prp18
View Download 0.282 N/A N/A a.47.2 t-snare proteins
View Download 0.281 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.281 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.279 N/A N/A d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.278 N/A N/A a.29.2 Bromodomain
View Download 0.276 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.273 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.273 N/A N/A a.118.8 TPR-like
View Download 0.273 N/A N/A a.142.1 PTS-regulatory domain, PRD
View Download 0.270 N/A N/A a.39.1 EF-hand
View Download 0.263 N/A N/A d.189.1 PX domain
View Download 0.263 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.262 N/A N/A a.4.1 Homeodomain-like
View Download 0.258 N/A N/A a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.257 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.255 N/A N/A a.25.1 Ferritin-like
View Download 0.252 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.251 N/A N/A c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.251 N/A N/A a.81.1 N-terminal domain of DnaB helicase
View Download 0.248 N/A N/A i.11.1 Computational models partly based on NMR data
View Download 0.246 N/A N/A a.25.1 Ferritin-like
View Download 0.246 N/A N/A a.47.2 t-snare proteins
View Download 0.245 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.245 N/A N/A a.95.1 Influenza virus matrix protein M1
View Download 0.242 N/A N/A d.65.1 Hedgehog/DD-pepidase
View Download 0.241 N/A N/A d.13.1 HIT-like
View Download 0.239 N/A N/A a.77.1 DEATH domain
View Download 0.239 N/A N/A d.79.1 YjgF-like
View Download 0.238 N/A N/A a.19.1 Fertilization protein
View Download 0.237 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.237 N/A N/A a.24.3 Cytochromes
View Download 0.235 N/A N/A a.63.1 Apolipophorin-III
View Download 0.232 N/A N/A d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.230 N/A N/A d.58.34 Formiminotransferase domain of formiminotransferase-cyclodeaminase.
View Download 0.228 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.228 N/A N/A a.74.1 Cyclin-like
View Download 0.227 N/A N/A a.165.1 Myosin phosphatase inhibitor 17kDa protein, CPI-17
View Download 0.225 N/A N/A a.22.1 Histone-fold
View Download 0.223 N/A N/A a.5.6 Hypothetical protein MTH1615
View Download 0.223 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.223 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.222 N/A N/A a.1.1 Globin-like
View Download 0.220 N/A N/A d.150.1 4'-phosphopantetheinyl transferase
View Download 0.220 N/A N/A d.58.5 GlnB-like
View Download 0.215 N/A N/A d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.214 N/A N/A a.2.5 Prefoldin
View Download 0.214 N/A N/A a.1.1 Globin-like
View Download 0.213 N/A N/A d.74.4 Prokaryotic AspRS, insert domain
View Download 0.211 N/A N/A a.24.1 Apolipoprotein
View Download 0.211 N/A N/A d.58.48 MTH1187-like
View Download 0.209 N/A N/A d.41.4 Ribosomal protein L10e
View Download 0.209 N/A N/A e.20.1 Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
View Download 0.209 N/A N/A d.58.16 Poly(A) polymerase, C-terminal domain
View Download 0.208 N/A N/A a.158.1 F-box domain
View Download 0.206 N/A N/A c.61.1 PRTase-like
View Download 0.204 N/A N/A d.92.2 beta-N-acetylhexosaminidase-like domain
View Download 0.203 N/A N/A a.24.3 Cytochromes

Predicted functions:

Term Confidence Notes
binding 3.44539235794744 bayes_pls_golite062009
transcription regulator activity 2.34092044533955 bayes_pls_golite062009
protein binding 1.97365365208963 bayes_pls_golite062009
nucleic acid binding 1.74252996786746 bayes_pls_golite062009
DNA binding 1.73786982174918 bayes_pls_golite062009
transcription factor activity 1.0565013251721 bayes_pls_golite062009
clathrin binding 0.196939581490181 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [118-460]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGLPLFEGSA LEKIEQFLIK ASALHQKNLQ AMLPTPTVPL LLRDIDKLTC LTSERLKNQP  60
   61 NDEKLKMKLL VLSQLKQELK REKLTLNALK QVQMQLRQVF SQDQQVLQER MRYHELQQQQ 120
  121 QQQQQQQQQQ QQQQQQYHET KDMVGSYTQN SNSAIPLFGN NSDTTNQQNS LSSSLFGNIS 180
  181 GVESFQEIEK KKSLNKINNL YASLKAEGLI YTPPKESIVT LYKKLNGHSN YSLDSHEKQL 240
  241 MKNLPKIPLL NDILSDCKAY FATVNIDVLN NPSLQLSEQT LLQENPIVQN NLIHLLYRSK 300
  301 PNKCSVCGKR FGNSESEKLL QNEHLDWHFR INTRIKGSQN TAN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [461-514]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGISNSNLNT TTTRKNIQSR NWYLSDSQWA AFKDDEITST KHKNDYTDPH ANKN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.342 d.17.3 Disulfide bond isomerase, DsbC, N-terminal domain

Predicted Domain #4
Region A:
Residues: [515-626]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDKSALNIHA DENDEGSVDN TLGSDRSNEL EIRGKYVVVP ETSQDMAFKC PICKETVTGV  60
   61 YDEESGEWVW KNTIEVNGKY FHSTCYHETS QNSSKSNSGK VGLDDLKKLV TK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.236 N/A N/A c.51.2 TolB, N-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle