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View Structure Prediction Details

Protein: TCP1
Organism: Saccharomyces cerevisiae
Length: 559 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TCP1.

Description E-value Query
Range		 Subject
Range
gi|4973187, gi|4... - gi|4973187|gb|AAD34970.1|AF143493_1 t-complex polypeptide 1 [Danio rerio], gi|42542939|gb|AAH66538.1...
 0.0 [5..556] [1..543]
TCPA_CRIGR - T-complex protein 1 subunit alpha OS=Cricetulus griseus GN=TCP1 PE=2 SV=1
 0.0 [6..557] [1..543]
TCPA_RAT - T-complex protein 1 subunit alpha OS=Rattus norvegicus GN=Tcp1 PE=1 SV=1
 0.0 [6..557] [1..543]
TCP1 - Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; inv...
gi|151942192 - gi|151942192|gb|EDN60548.1| chaperonin subunit alpha [Saccharomyces cerevisiae YJM789]
gi|190404836 - gi|190404836|gb|EDV08103.1| T-complex protein 1 subunit alpha [Saccharomyces cerevisiae RM11-1a]
TCPA_YEAST - T-complex protein 1 subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TCP1 P...
 0.0 [1..559] [1..559]
TCPA_MOUSE - T-complex protein 1 subunit alpha OS=Mus musculus GN=Tcp1 PE=1 SV=3
gi|258450 - gi|258450|gb|AAB23855.1| t-complex polypeptide 1; TCP-1 [Mus sp.]
gi|55249846 - gb|AAH86000.1| Unknown (protein for MGC:98023) [Xenopus laevis]
 0.0 [6..557] [1..543]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
 0.0 [6..557] [1..543]
gi|18978346, gi|... - gi|18978346|ref|NP_579703.1| thermosome, single subunit [Pyrococcus furiosus DSM 3638], gi|18894178|...
 0.0 [1..549] [1..526]

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Predicted Domain #1
Region A:
Residues: [1-110] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQLFNNSRS DTLFLGGEKI SGDDIRNQNV LATMAVANVV KSSLGPVGLD KMLVDDIGDF  60
   61 TVTNDGATIL SLLDVQHPAG KILVELAQQQ DREIGDGTTS VVIIASELLK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [144-420] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSTSVDTLGK ETLINIAKTS MSSKIIGADS DFFSNMVVDA LLAVKTQNSK GEIKYPVKAV  60
   61 NVLKAHGKSA TESLLVPGYA LNCTVASQAM PKRIAGGNVK IACLDLNLQK ARMAMGVQIN 120
  121 IDDPEQLEQI RKREAGIVLE RVKKIIDAGA QVVLTTKGID DLCLKEFVEA KIMGVRRCKK 180
  181 EDLRRIARAT GATLVSSMSN LEGEETFESS YLGLCDEVVQ AKFSDDECIL IKGTSKHSSS 240
  241 SIILRGANDY SLDEMERSLH DSLSVVKRTL ESGNVVP

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [515-559] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGVLEPTISK VKSLKSALEA CVAILRIDTM ITVDPEPPKE DPHDH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1008.9897
Match: 1a6dA_
Description: Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
unfolded protein binding 7.60116801069598 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 3.6934849790316 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 3.40373598585301 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 3.28982639907979 bayes_pls_golite062009
binding 2.07154556649829 bayes_pls_golite062009
nucleic acid binding 1.67284737458957 bayes_pls_golite062009
DNA binding 1.60256620441721 bayes_pls_golite062009
transporter activity 1.27879339110564 bayes_pls_golite062009
transmembrane transporter activity 1.08697283907212 bayes_pls_golite062009
chaperone binding 0.91200031047441 bayes_pls_golite062009
substrate-specific transporter activity 0.828920415160435 bayes_pls_golite062009
ATPase activity, coupled 0.787685249362834 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.75018875403424 bayes_pls_golite062009
pyrophosphatase activity 0.69634667457441 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.682843768728088 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.680378643689288 bayes_pls_golite062009
protein binding 0.634982583867058 bayes_pls_golite062009
ATPase activity 0.584574936611857 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.573106450426516 bayes_pls_golite062009
catalytic activity 0.424959044318554 bayes_pls_golite062009
ion transmembrane transporter activity 0.280310103153739 bayes_pls_golite062009
active transmembrane transporter activity 0.275534581026027 bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism 0.26275673855778 bayes_pls_golite062009
primary active transmembrane transporter activity 0.252704226951294 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.243984617084631 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.205808843369749 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.202279803135899 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.20198255686005 bayes_pls_golite062009
transferase activity 0.18639662517366 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.16424934648837 bayes_pls_golite062009
kinase activity 0.0871496920547826 bayes_pls_golite062009
cation transmembrane transporter activity 0.0778814959589007 bayes_pls_golite062009
hydrolase activity 0.0491351110520448 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [111-143] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RANELVKNKI HPTTIITGFR VALREAIRFI NEV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [421-514] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGCVEAALN IYLDNFATTV GSREQLAIAE FAAALLIIPK TLAVNAAKDS SELVAKLRSY  60
   61 HAASQMAKPE DVKRRSYRNY GLDLIRGKIV DEIH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1008.9897
Match: 1a6dA_
Description: Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle