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View Structure Prediction Details

Protein: INO2
Organism: Saccharomyces cerevisiae
Length: 304 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for INO2.

Description E-value Query
Range
Subject
Range
INO2_YEAST - Protein INO2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=INO2 PE=1 SV=1
gi|190404915 - gi|190404915|gb|EDV08182.1| helix-loop-helix protein [Saccharomyces cerevisiae RM11-1a]
INO2 - Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds i...
gi|207346707 - gi|207346707|gb|EDZ73125.1| YDR123Cp-like protein [Saccharomyces cerevisiae AWRI1631]
0.0 [1..304] [1..304]

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Predicted Domain #1
Region A:
Residues: [1-214]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQATGNELL GILDLDNDID FETAYQMLSS NFDDQMSAHI HENTFSATSP PLLTHELGII  60
   61 PNVATVQPSH VETIPADNQT HHAPLHTHAH YLNHNPHQPS MGFDQALGLK LSPSSSGLLS 120
  121 TNESNAIEQF LDNLISQDMM SSNASMNSES HLHIRSPKKQ HRYTELNQRY PETHPHSNTG 180
  181 ELPTNTADVP TEFTTREGPH QPIGNDHYNP PPFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [215-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPEIRIPDSD IPANIEDDPV KVRKWKHVQM EKIRRINTKE AFERLIKSVR TPPKENGKRI  60
   61 PKHILLTCVM NDIKSIRSAN EALQHILDDS 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 2.522879
Match: PF00010
Description: Helix-loop-helix DNA-binding domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.08855036296174 bayes_pls_golite062009
DNA binding 4.87243318281876 bayes_pls_golite062009
nucleic acid binding 4.77537175825177 bayes_pls_golite062009
transcription factor activity 4.43134840465732 bayes_pls_golite062009
binding 3.63719401349018 bayes_pls_golite062009
transcription activator activity 3.62180682771335 bayes_pls_golite062009
sequence-specific DNA binding 3.17029130860224 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.11931609869373 bayes_pls_golite062009
protein binding 2.53793947976093 bayes_pls_golite062009
transcription factor binding 2.33137487648005 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.01283700957804 bayes_pls_golite062009
transcription cofactor activity 1.30186253699056 bayes_pls_golite062009
transcription repressor activity 0.828519845330998 bayes_pls_golite062009
transcription corepressor activity 0.560586077390024 bayes_pls_golite062009
promoter binding 0.531949034115114 bayes_pls_golite062009
protein heterodimerization activity 0.328788240668351 bayes_pls_golite062009
transcription coactivator activity 0.172100901723138 bayes_pls_golite062009
protein dimerization activity 0.0815596840205237 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle