YRC Public Data Repository - Protein Structure Prediction

Protein:	MSH5
Organism:	Saccharomyces cerevisiae
Length:	901 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSH5.

Description	E-value	Query Range	Subject Range
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	0.0	[1..901]	[1..901]
MSH5 - Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs du... MSH5_YEAST - MutS protein homolog 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSH5 PE=1 SV=1	0.0	[1..901]	[1..901]
gi\|205324663, gi... - gi\|205324663\|gb\|EDZ12502.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enterica se... gi\|167993148, gi... - gi\|205328749\|gb\|EDZ15513.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enterica se... gi\|168242649, gi... - gi\|205338197\|gb\|EDZ24961.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enterica se... MUTS_SALCH - DNA mismatch repair protein MutS OS=Salmonella choleraesuis (strain SC-B67) GN=mutS PE=3 SV=1 lcl\|NC_016856.1_... - [gene=mutS] [protein=DNA mismatch repair protein] [protein_id=YP_005239020.1] [location=3070516..307... MUTS_SALTY - DNA mismatch repair protein mutS OS=Salmonella typhimurium GN=mutS PE=1 SV=1 MUTS_SALCH - DNA mismatch repair protein mutS OS=Salmonella choleraesuis GN=mutS PE=3 SV=1 MUTS_SALCH - DNA mismatch repair protein mutS OS=Salmonella choleraesuis GN=mutS PE=3 SV=1 MUTS_SALTI - DNA mismatch repair protein MutS OS=Salmonella typhi GN=mutS PE=3 SV=1 MUTS_SALG2 - DNA mismatch repair protein MutS OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=mutS PE=3 ... MUTS_SALTY - DNA mismatch repair protein MutS OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=... gi\|213854165 - gi\|213854165\|ref\|ZP_03382697.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica ser... MUTS_SALTY - DNA mismatch repair protein mutS OS=Salmonella typhimurium GN=mutS PE=1 SV=1 MUTS_SALPB - DNA mismatch repair protein mutS OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=mutS PE=... MUTS_SALPB - DNA mismatch repair protein MutS OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=mutS PE=... MUTS_SALTI - DNA mismatch repair protein mutS OS=Salmonella typhi GN=mutS PE=3 SV=1 gi\|168463951, gi... - gi\|195633763\|gb\|EDX52177.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enterica se... MUTS_SALHS - DNA mismatch repair protein MutS OS=Salmonella heidelberg (strain SL476) GN=mutS PE=3 SV=1 gi\|29143167, gi\|... - gi\|29143167\|ref\|NP_806509.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica serova... MUTS_SALA4 - DNA mismatch repair protein MutS OS=Salmonella agona (strain SL483) GN=mutS PE=3 SV=1 gi\|16761683 - gi\|16761683\|ref\|NP_457300.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica serova... gi\|197240275, gi... - gi\|197262020\|ref\|ZP_03162094.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enteric...	0.0	[28..899]	[30..854]
gi\|125617373, gi... - gi\|75829241\|ref\|ZP_00758551.1\| COG0249: Mismatch repair ATPase (MutS family) [Vibrio cholerae MO10],... gi\|229353916, gi... - gi\|229508991\|ref\|ZP_04398479.1\| DNA mismatch repair protein MutS [Vibrio cholerae B33], gi\|229353916... MUTS_VIBCH - DNA mismatch repair protein mutS OS=Vibrio cholerae GN=mutS PE=3 SV=1 MUTS_VIBCH - DNA mismatch repair protein MutS OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N1... gi\|75815683 - gi\|75815683\|ref\|ZP_00746180.1\| COG0249: Mismatch repair ATPase (MutS family) [Vibrio cholerae V52] MUTS_VIBCM - DNA mismatch repair protein MutS OS=Vibrio cholerae serotype O1 (strain M66-2) GN=mutS PE=3 SV=1 gi\|229507146, gi... - gi\|229507146\|ref\|ZP_04396652.1\| DNA mismatch repair protein MutS [Vibrio cholerae BX 330286], gi\|229... gi\|229344348, gi... - gi\|229519659\|ref\|ZP_04409102.1\| DNA mismatch repair protein MutS [Vibrio cholerae RC9], gi\|229344348... MUTS_VIBC3 - DNA mismatch repair protein MutS OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa... gi\|153223827, gi... - gi\|153223827\|ref\|ZP_01954082.1\| DNA mismatch repair protein MutS [Vibrio cholerae MAK 757], gi\|12411... gi\|126510344, gi... - gi\|153819112\|ref\|ZP_01971779.1\| DNA mismatch repair protein MutS [Vibrio cholerae NCTC 8457], gi\|126...	0.0	[26..900]	[31..862]
gi\|22124746, gi\|... - gi\|22124746\|ref\|NP_668169.1\| DNA mismatch repair protein [Yersinia pestis KIM], gi\|21957565\|gb\|AAM84... gi\|218930372, gi... - gi\|218930372\|ref\|YP_002348247.1\| DNA mismatch repair protein MutS [Yersinia pestis CO92], gi\|1612350... gi\|45435046, gi\|... - gi\|45440190\|ref\|NP_991729.1\| DNA mismatch repair protein [Yersinia pestis biovar Microtus str. 91001... MUTS_YERPG - DNA mismatch repair protein MutS OS=Yersinia pestis bv. Antiqua (strain Angola) GN=mutS PE=3 SV=1 gi\|167469363 - gi\|167469363\|ref\|ZP_02334067.1\| DNA mismatch repair protein MutS [Yersinia pestis FV-1] gi\|167423797, gi... - gi\|167423797\|ref\|ZP_02315550.1\| DNA mismatch repair protein MutS [Yersinia pestis biovar Mediaevalis... gi\|149289239, gi... - gi\|153997602\|ref\|ZP_02022702.1\| DNA mismatch repair protein MutS [Yersinia pestis CA88-4125], gi\|149... MUTS_YERPP - DNA mismatch repair protein MutS OS=Yersinia pestis (strain Pestoides F) GN=mutS PE=3 SV=1 gi\|166010151, gi... - gi\|166010151\|ref\|ZP_02231049.1\| DNA mismatch repair protein MutS [Yersinia pestis biovar Antiqua str... MUTS_YERPE - DNA mismatch repair protein MutS OS=Yersinia pestis GN=mutS PE=3 SV=1 gi\|165922488, gi... - gi\|165925876\|ref\|ZP_02221708.1\| DNA mismatch repair protein MutS [Yersinia pestis biovar Orientalis ... gi\|229695346, gi... - gi\|229838980\|ref\|ZP_04459139.1\| methyl-directed mismatch repair protein [Yersinia pestis biovar Orie... gi\|167421538, gi... - gi\|167421538\|ref\|ZP_02313291.1\| DNA mismatch repair protein MutS [Yersinia pestis biovar Orientalis ... gi\|229687039, gi... - gi\|229899547\|ref\|ZP_04514688.1\| methyl-directed mismatch repair protein [Yersinia pestis biovar Orie... gi\|166205736, gi... - gi\|166212949\|ref\|ZP_02238984.1\| DNA mismatch repair protein MutS [Yersinia pestis biovar Antiqua str... gi\|165936708, gi... - gi\|89105881\|ref\|ZP_01178393.1\| COG0249: Mismatch repair ATPase (MutS family) [Yersinia pestis biovar... MUTS_YERPN - DNA mismatch repair protein MutS OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=mutS PE=3 SV=1	0.0	[28..899]	[28..850]
EG10625 - methyl-directed mismatch repair protein / Methyl-directed mismatch repair protein, weak ATPase; dime... MUTS_ECOHS - DNA mismatch repair protein MutS OS=Escherichia coli O9:H4 (strain HS) GN=mutS PE=3 SV=1 gi\|124500877, gi... - gi\|124527985\|ref\|ZP_01699338.1\| DNA mismatch repair protein MutS [Escherichia coli B], gi\|124500877\|... MUTS_ECOLC - DNA mismatch repair protein MutS OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=mutS ... gi\|85675554, gi\|... - gi\|89109520\|ref\|AP_003300.1\| methyl-directed mismatch repair protein [Escherichia coli str. K-12 sub... MUTS_ECODH - DNA mismatch repair protein MutS OS=Escherichia coli (strain K12 / DH10B) GN=mutS PE=3 SV=1 gi\|194438950, gi... - gi\|194438950\|ref\|ZP_03071034.1\| DNA mismatch repair protein MutS [Escherichia coli 101-1], gi\|194422... gi\|254289425, gi... - gi\|254289425\|ref\|YP_003055173.1\| DNA mismatch repair protein [Escherichia coli BL21(DE3)], gi\|253978... gi\|253974565, gi... - gi\|254162664\|ref\|YP_003045772.1\| DNA mismatch repair protein [Escherichia coli B str. REL606], gi\|25... MUTS_ECOLI - DNA mismatch repair protein mutS - Escherichia coli MUTS_ECOBW - DNA mismatch repair protein MutS OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=mutS PE=3 SV=... EG10625 - methyl-directed mismatch repair protein / Methyl-directed mismatch repair protein, weak ATPase; dime... gi\|242378289, gi... - gi\|251786016\|ref\|YP_003000320.1\| hypothetical protein B21_02548 [Escherichia coli BL21], gi\|24237828...	0.0	[28..899]	[28..852]
gi\|254594075, gi... - gi\|254794675\|ref\|YP_003079512.1\| methyl-directed mismatch repair protein [Escherichia coli O157:H7 s... gi\|208739537, gi... - gi\|208819414\|ref\|ZP_03259734.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC40... gi\|208735412, gi... - gi\|208814135\|ref\|ZP_03255464.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC40... MUTS_ECO8A - DNA mismatch repair protein MutS OS=Escherichia coli O8 (strain IAI1) GN=mutS PE=3 SV=1 MUTS_ECO5E - DNA mismatch repair protein MutS OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=mutS PE=3 SV=... gi\|192957000, gi... - gi\|193069637\|ref\|ZP_03050589.1\| DNA mismatch repair protein MutS [Escherichia coli E110019], gi\|1929... gi\|191166787, gi... - gi\|191166787\|ref\|ZP_03028613.1\| DNA mismatch repair protein MutS [Escherichia coli B7A], gi\|19090315... gi\|208807935, gi... - gi\|208807935\|ref\|ZP_03250272.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC42... gi\|195938486 - gi\|195938486\|ref\|ZP_03083868.1\| DNA mismatch repair protein [Escherichia coli O157:H7 str. EC4024] gi\|15832843, gi\|... - gi\|15832843\|ref\|NP_311616.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. Sakai],... gi\|168787991, gi... - gi\|189372119\|gb\|EDU90535.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC869], ... gi\|168778718, gi... - gi\|189003145\|gb\|EDU72131.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC4076],... gi\|188493251, gi... - gi\|188493251\|ref\|ZP_03000521.1\| DNA mismatch repair protein MutS [Escherichia coli 53638], gi\|188488... gi\|189377459, gi... - gi\|189377459\|gb\|EDU95875.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC508], ... gi\|189357264, gi... - gi\|189357264\|gb\|EDU75683.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC4401],... gi\|188015814, gi... - gi\|188015814\|gb\|EDU53936.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC4113],... gi\|168774732, gi... - gi\|187769600\|gb\|EDU33444.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC4196],... gi\|168768827, gi... - gi\|189362111\|gb\|EDU80530.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC4486],... MUTS_ECO57 - DNA mismatch repair protein MutS OS=Escherichia coli O157:H7 GN=mutS PE=3 SV=1 gi\|25317150, gi\|... - gi\|4887554\|emb\|CAB43497.1\| mismatch repair protein [Escherichia coli], pir\|\|E91077 MutS protein [imp...	0.0	[28..899]	[28..852]
gi\|12517186, gi\|... - gi\|15803252\|ref\|NP_289284.1\| DNA mismatch repair protein [Escherichia coli O157:H7 EDL933], gi\|12517... gi\|25317161 - gi\|25317161\|pir\|\|F85922 methyl-directed mismatch repair [imported] - Escherichia coli (strain O157:H...	0.0	[28..899]	[28..852]
gi\|1592569 - gi\|1592569\|gb\|AAB97931.1\| DNA mismatch repair protein [Escherichia coli]	0.0	[28..899]	[28..852]
MUTS_HAEIN - DNA mismatch repair protein mutS OS=Haemophilus influenzae GN=mutS PE=3 SV=1 MUTS_HAEIN - DNA mismatch repair protein MutS OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / R...	0.0	[26..899]	[26..859]

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Predicted Domain #1

Region A:
Residues: [1-244]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHEWLISAS ETMRSIGNGE GLRDKGAVVA NNDGEFNEGD TNREEDSSTI FSFDFDEEIV  60
   61 MCIDFSGGKL GCSILDYHTK TLKAFDQDYV VNKTTISSHD LIDDADMSSN DISLLLGLLI 120
  121 MEANPTVCLV PARLEDWIFD YIKTKCDEIN CRLELQPIKR FKKWDLLQSL QLRGHDNQTI 180
  181 LNDILSNSKF TTTVTLGTVG CILANHEQLG EYNDSTASSN MVTGRLVQNA FEDVIHGIRY 240
  241 IDIR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1265.228787
Match:	1e3mA_
Description:	DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [245-273]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRMVLDENTI SALHIFPTAH KLGHDKMMR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [580-901]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AERNYAEPQL VEDECILEII NGRHALYETF LDNYIPNSTM IDGGLFSELS WCEQNKGRII  60
   61 VVTGANASGK SVYLTQNGLI VYLAQIGCFV PAERARIGIA DKILTRIRTQ ETVYKTQSSF 120
  121 LLDSQQMAKS LSLATEKSLI LIDEYGKGTD ILDGPSLFGS IMLNMSKSEK CPRIIACTHF 180
  181 HELFNENVLT ENIKGIKHYC TDILISQKYN LLETAHVGED HESEGITFLF KVKEGISKQS 240
  241 FGIYCAKVCG LSRDIVERAE ELSRMINRGD DVVQQCGNLT EKEMREFQKN QEIVKKFLSW 300
  301 DLDLETTTTS ENLRLKLKNF LR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1265.228787
Match:	1e3mA_
Description:	DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [274-439]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGFFSVFELF NQVSSDYARR ILKSWLINPL TNKKRIETRY SIIRTLLDKQ NAIIFSDLSQ  60
   61 SIKRCPDAFG FINQLRSGKS TLGTWSKVAS FLEKGIAIFQ LVSSLKLGSD EANILHDIKN 120
  121 KVDISALKEC LRKVETVIDF DTSRDTKTLT INTGVDNRLD ECRNIY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [532-579]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIYGAISDFE IEILFSLQEQ ILRRKTQLTA YNILLSELEI LLSFAQVS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1265.228787
Match:	1e3mA_
Description:	DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [440-531]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NHLEGILLDV ARETQIFLLN TMPQEDCKTT KSLEKLVNAV YIPQLGYLVT ISVLMEPLLD  60
   61 GIPNLQWEEI FRSSENIYFK NGRVLELDET YG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1265.228787
Match:	1e3mA_
Description:	DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits