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View Structure Prediction Details

Protein: PHO2
Organism: Saccharomyces cerevisiae
Length: 559 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHO2.

Description E-value Query
Range
Subject
Range
PHO2 - Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; bi...
PHO2_YEAST - Regulatory protein PHO2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PHO2 PE=1 SV=1
0.0 [1..559] [1..559]
gi|2696972 - gi|2696972|dbj|BAA24025.1| PAX6 SL [Cynops pyrrhogaster]
2.0E-47 [36..247] [181..402]
gi|2950355 - gi|2950355|emb|CAA11241.1| homebox protein DRx [Drosophila melanogaster]
5.0E-47 [6..333] [483..846]
gi|5758939 - gi|5758939|gb|AAD50903.1|AF169414_1 paired-box transcription factor -+ isoform [Ambystoma mexicanum]
6.0E-47 [36..247] [162..383]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
4.0E-46 [55..298] [195..435]
gi|1685047 - gi|1685047|gb|AAB36681.1| paired-type homeodomain Pax-6 protein [Xenopus laevis]
5.0E-46 [36..247] [195..417]
PAX7 - paired box 7
5.0E-46 [55..298] [195..435]

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Predicted Domain #1
Region A:
Residues: [1-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMEEFSYDHD FNTHFATDLD YLQHDQQQQQ QQQHDQQHNQ QQQPQPQPIQ TQNLEHDHDQ  60
   61 HTNDMSASSN ASDSGPQRPK RTRAKGEALD VLKRKFEINP TPSLVERKKI SDLIGMPEKN 120
  121 VRIWFQNRRA KLRKKQHG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 83.529817
Match: 1fjlA_
Description: Paired protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.41876985649951 bayes_pls_golite062009
nucleic acid binding 4.09724849396574 bayes_pls_golite062009
transcription factor activity 3.86239731611043 bayes_pls_golite062009
binding 3.55096238224843 bayes_pls_golite062009
sequence-specific DNA binding 2.32406445003946 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.04108499638264 bayes_pls_golite062009
protein binding 0.891078200474841 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
chromatin binding 0.821515245941799 bayes_pls_golite062009
transcription corepressor activity 0.12996981272574 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [139-295]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNKDTIPSSQ SRDIANDYDR GSTDNNLVTT TSTSSIFHDE DLTFFDRIPL NSNNNYYFFD  60
   61 ICSITVGSWN RMKSGALQRR NFQSIKELRN LSPIKINNIM SNATDLMVLI SKKNSEINYF 120
  121 FSAMANNTKI LFRIFFPLSS VTNCSLTLET DDDIINS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [329-340]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAKDNFGELK LT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.23
Match: 1ruxA
Description: Adenovirus hexon

Predicted Domain #3
Region A:
Residues: [296-328]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNTSDKNNSN TNNDDDNDDN SNEDNDNSSE DKR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [341-559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTRSPTFAVY FLNNAPDEDP NLNNQWSICD DFSEGRQVND AFVGGSNIPH TLKGLQKSLR  60
   61 FMNSLILDYK SSNEILPTIN TAIPTAAVPQ QNIAPPFLNT NSSATDSNPN TNLEDSLFFD 120
  121 HDLLSSSITN TNNGQGSNNG RQASKDDTLN LLDTTVNSNN NHNANNEENH LAQEHLSNDA 180
  181 DIVANPNDHL LSLPTDSELP NTPDFLKNTN ELTDEHRWI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.23
Match: 1ruxA
Description: Adenovirus hexon

Predicted Domain #4
Region A:
Residues: [458-559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FFDHDLLSSS ITNTNNGQGS NNGRQASKDD TLNLLDTTVN SNNNHNANNE ENHLAQEHLS  60
   61 NDADIVANPN DHLLSLPTDS ELPNTPDFLK NTNELTDEHR WI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle