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View Structure Prediction Details

Protein: HMLALPHA2, MATALPHA2
Organism: Saccharomyces cerevisiae
Length: 210 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMLALPHA2, MATALPHA2.

Description E-value Query
Range		 Subject
Range
ORFP:2769 - Multiple, Contig c90 47204-47836 reverse complement
HMLALPHA2, MATALPHA2 - Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells ...
Sbay_623.22, Sba... - probable YCL067C HMLALPHA2 (37996-38628), null
gi|151943860 - gi|151943860|gb|EDN62160.1| mating type protein alpha [Saccharomyces cerevisiae YJM789]
MTAL2_YEAST, HMA... - Mating-type protein ALPHA2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MATALPHA2 PE=...
gi|190406384 - gi|190406384|gb|EDV09651.1| mating-type protein alpha-2 [Saccharomyces cerevisiae RM11-1a]
 1.0E-43 [1..210] [1..210]
HXA7_MOUSE - Homeobox protein Hox-A7 OS=Mus musculus GN=Hoxa7 PE=2 SV=2
 2.0E-35 [2..207] [12..204]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 8.0E-35 [2..207] [12..204]
HXA7_XENLA - Homeobox protein Hox-A7 OS=Xenopus laevis GN=hoxa7 PE=2 SV=1
 8.0E-34 [2..209] [12..199]
PBX4 - pre-B-cell leukemia homeobox 4
gi|148745216 - gi|148745216|gb|AAI43093.1| Pre-B-cell leukemia homeobox 4 [synthetic construct]
 2.0E-33 [28..210] [101..292]
MTAL2_KLULA - Mating-type protein ALPHA2 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1...
MTAL2_KLULA - Mating-type protein ALPHA2 OS=Kluyveromyces lactis GN=HMLALPHA2 PE=3 SV=1
 1.0E-32 [1..201] [1..223]

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Predicted Domain #1
Region A:
Residues: [1-101] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKIPIKDLL NPQITDEFKS SILDINKKLF SICCNLPKLP ESVTTEEEVE LRDILGFLSR  60
   61 ANKNRKISDE EKKLLQTTSQ LTTTITVLLK EMRSIENDRS N

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.994 0.031 regulation of transcription, mating-type specific a.47.2 t-snare proteins

Predicted Domain #2
Region A:
Residues: [102-210] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YQLTQKNKSA DGLVFNVVTQ DMINKSTKPY RGHRFTKENV RILESWFAKN IENPYLDTKG  60
   61 LENLMKNTSL SRIQIKNWVS NRRRKEKTIT IAPELADLLS GEPLAKKKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 399.522879
Match: 1mnmC_
Description: mat alpha2 Homeodomain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle