YRC Public Data Repository - Protein Structure Prediction

Protein:	SDS24
Organism:	Saccharomyces cerevisiae
Length:	527 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SDS24.

Description	E-value	Query Range	Subject Range
SDS24 - One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implic... SDS24_YEAS7 - Protein SDS24 OS=Saccharomyces cerevisiae (strain YJM789) GN=SDS24 PE=3 SV=1 SDS24_YEAST - Protein SDS24 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SDS24 PE=1 SV=1	3.0E-74	[1..527]	[1..527]
PRKAG2 - protein kinase, AMP-activated, gamma 2 non-catalytic subunit	8.0E-50	[2..426]	[133..565]
gi\|19570823 - gi\|19570823\|dbj\|BAB86329.1\| Sk-SDS23 [Lachancea kluyveri]	1.0E-49	[2..399]	[3..375]
AAKG2_MOUSE - 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=1	2.0E-49	[2..426]	[133..562]
AAKG3_PIG - 5'-AMP-activated protein kinase subunit gamma-3 OS=Sus scrofa GN=PRKAG3 PE=1 SV=2	5.0E-49	[2..420]	[60..457]
gi\|220948160 - gi\|220948160\|gb\|ACL86623.1\| SNF4Agamma-PC [synthetic construct] SNF4Agamma-PK, S... - The gene SNF4/AMP-activated protein kinase gamma subunit is referred to in FlyBase by the symbol Dme...	4.0E-47	[68..424]	[403..731]

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Predicted Domain #1

Region A:
Residues: [1-95]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASTSNTFPP SQSNSSNNLP TSRHASIVEM LSTPPLLPHV QVNDTDDKEQ PEESTPPTAT  60
   61 AAAPGPGCAA TPAPLRDEKP QFKLSAVPMT QTPSQ

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [96-197]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CLSCVHAQKW QHIPLSQLIE QNKLIFVPGS ISVEEAFNTL IKYHLNSIPV ESFPGDMNCF  60
   61 TFDYNDLNSY LLLVLNKITV SNKQLTADCQ NGKPVPVGEM VK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [333-527]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HVTRTSQYPL LHKTCRHFIS VILNSRGLET GKDSFPIFHV YPSSSLARTL AKLVATKSHR  60
   61 LWIVQPPESS TSASSTNLTA ANTAANAVSA TAQSSANGAT PMSKSSSSTS LNSHSPLMTA 120
  121 MEDPPSPRSS AIAIPPPSPA SSTNTPNLFE KEYRTGKLIG VVSLTDIINL LARKQTGNKE 180
  181 VDPQSARRQR GSIAM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.045757
Match:	1zfjA_
Description:	Inosine monophosphate dehydrogenase (IMPDH); Type II inosine monophosphate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transporter activity	0.961062314616209	bayes_pls_golite062009
transmembrane transporter activity	0.807029018941177	bayes_pls_golite062009
binding	0.804248460382476	bayes_pls_golite062009
substrate-specific transporter activity	0.640881170978843	bayes_pls_golite062009
protein binding	0.5290109527055	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.525366315833255	bayes_pls_golite062009
ion transmembrane transporter activity	0.440262824681055	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [198-332]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTPKNPFYKL PENESLSTVM GILGSGVHRV AITNEEMTKV KGILSQRRLI KYLWDNARSF  60
   61 TSLEPLLNSS LQDLHIGVLN IQSKPTSRQS RVISIQGEEP LIMGLYKMHV ERISSIAVID 120
  121 KQGNLLGNIS VTDVK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.045757
Match:	1zfjA_
Description:	Inosine monophosphate dehydrogenase (IMPDH); Type II inosine monophosphate dehydrogenase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: