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View Structure Prediction Details

Protein: SDS24
Organism: Saccharomyces cerevisiae
Length: 527 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SDS24.

Description E-value Query
Range
Subject
Range
SDS24 - One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implic...
SDS24_YEAS7 - Protein SDS24 OS=Saccharomyces cerevisiae (strain YJM789) GN=SDS24 PE=3 SV=1
SDS24_YEAST - Protein SDS24 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SDS24 PE=1 SV=1
3.0E-74 [1..527] [1..527]
PRKAG2 - protein kinase, AMP-activated, gamma 2 non-catalytic subunit
8.0E-50 [2..426] [133..565]
gi|19570823 - gi|19570823|dbj|BAB86329.1| Sk-SDS23 [Lachancea kluyveri]
1.0E-49 [2..399] [3..375]
AAKG2_MOUSE - 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=1
2.0E-49 [2..426] [133..562]
AAKG3_PIG - 5'-AMP-activated protein kinase subunit gamma-3 OS=Sus scrofa GN=PRKAG3 PE=1 SV=2
5.0E-49 [2..420] [60..457]
gi|220948160 - gi|220948160|gb|ACL86623.1| SNF4Agamma-PC [synthetic construct]
SNF4Agamma-PK, S... - The gene SNF4/AMP-activated protein kinase gamma subunit is referred to in FlyBase by the symbol Dme...
4.0E-47 [68..424] [403..731]

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Predicted Domain #1
Region A:
Residues: [1-95]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASTSNTFPP SQSNSSNNLP TSRHASIVEM LSTPPLLPHV QVNDTDDKEQ PEESTPPTAT  60
   61 AAAPGPGCAA TPAPLRDEKP QFKLSAVPMT QTPSQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.378 a.3.1 Cytochrome c
View Download 0.313 a.77.1 DEATH domain
View Download 0.283 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.366 c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.309 d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.378 a.3.1 Cytochrome c
View Download 0.366 c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.313 a.77.1 DEATH domain
View Download 0.309 d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.283 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.255 a.4.5 "Winged helix" DNA-binding domain
View Download 0.250 d.52.2 GMP synthetase C-terminal dimerisation domain
View Download 0.248 a.26.1 4-helical cytokines
View Download 0.224 d.52.1 Alpha-lytic protease prodomain
View Download 0.211 c.78.2 Aspartate/glutamate racemase
View Download 0.206 d.52.2 GMP synthetase C-terminal dimerisation domain

Predicted Domain #2
Region A:
Residues: [96-197]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CLSCVHAQKW QHIPLSQLIE QNKLIFVPGS ISVEEAFNTL IKYHLNSIPV ESFPGDMNCF  60
   61 TFDYNDLNSY LLLVLNKITV SNKQLTADCQ NGKPVPVGEM VK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [333-527]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HVTRTSQYPL LHKTCRHFIS VILNSRGLET GKDSFPIFHV YPSSSLARTL AKLVATKSHR  60
   61 LWIVQPPESS TSASSTNLTA ANTAANAVSA TAQSSANGAT PMSKSSSSTS LNSHSPLMTA 120
  121 MEDPPSPRSS AIAIPPPSPA SSTNTPNLFE KEYRTGKLIG VVSLTDIINL LARKQTGNKE 180
  181 VDPQSARRQR GSIAM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.045757
Match: 1zfjA_
Description: Inosine monophosphate dehydrogenase (IMPDH); Type II inosine monophosphate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transporter activity 0.961062314616209 bayes_pls_golite062009
transmembrane transporter activity 0.807029018941177 bayes_pls_golite062009
binding 0.804248460382476 bayes_pls_golite062009
substrate-specific transporter activity 0.640881170978843 bayes_pls_golite062009
protein binding 0.5290109527055 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.525366315833255 bayes_pls_golite062009
ion transmembrane transporter activity 0.440262824681055 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [198-332]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTPKNPFYKL PENESLSTVM GILGSGVHRV AITNEEMTKV KGILSQRRLI KYLWDNARSF  60
   61 TSLEPLLNSS LQDLHIGVLN IQSKPTSRQS RVISIQGEEP LIMGLYKMHV ERISSIAVID 120
  121 KQGNLLGNIS VTDVK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.045757
Match: 1zfjA_
Description: Inosine monophosphate dehydrogenase (IMPDH); Type II inosine monophosphate dehydrogenase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle