YRC Public Data Repository - Protein Structure Prediction

Protein:	TBS1
Organism:	Saccharomyces cerevisiae
Length:	1094 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TBS1.

Description	E-value	Query Range	Subject Range
TBS1_YEAST - Uncharacterized transcriptional regulatory protein TBS1 OS=Saccharomyces cerevisiae (strain ATCC 204... TBS1 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purifi...	0.0	[1..952]	[1..952]
gi\|6901427 - gi\|6901427\|emb\|CAB71797.1\| pathway-specific nitrogen regulator [Tolypocladium inflatum]	7.0E-82	[47..780]	[1..628]
YC79_SCHPO - Uncharacterized transcriptional regulatory protein C417.09c OS=Schizosaccharomyces pombe (strain 972... SPCC417.09c - transcription factor	8.0E-81	[75..862]	[41..736]
gi\|245224 - gi\|245224\|gb\|AAB21394.1\| NIT4=protein product involved in nitrate assimilation [Neurospora intermedi... NIT4_NEUCR - Nitrogen assimilation transcription factor nit-4 - Neurospora crassa	8.0E-79	[63..763]	[8..597]
gi\|1706177 - sp\|P52959\|CT1B_FUSSO CUTINASE TRANSCRIPTION FACTOR 1 BETA CTF1B_FUSSO - Cutinase transcription factor 1 beta OS=Fusarium solani subsp. pisi GN=CTF1-BETA PE=2 SV=1	2.0E-77	[71..732]	[3..607]

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Predicted Domain #1

Region A:
Residues: [1-57]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMDSGITSS HGSMDKTQKQ SSEWAANQKH NQRVENTRVL MGPAVPAMPP VPSNFPP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.731	0.853	nucleus	a.4.1	Homeodomain-like

Predicted Domain #2

Region A:
Residues: [58-178]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPTGTIMSPQ LSPFPDHRLR HHPLAHMMPA DKNFLAYNME SFKSRVTKAC DYCRKRKIRC  60
   61 TEIEPISGKC RNCIKYNKDC TFHFHEELKR RREEALNNKG NGKSVKKPRL DKENKFKDEN 120
  121 F

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.512579
Match:	1cld__
Description:	CD2-Lac9
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleic acid binding	2.55832554210202	bayes_pls_golite062009
DNA binding	2.48009340951204	bayes_pls_golite062009
transcription regulator activity	2.39344671016496	bayes_pls_golite062009
binding	2.32645838605286	bayes_pls_golite062009
transcription factor activity	1.25308658158845	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.75311920044374	bayes_pls_golite062009
sequence-specific DNA binding	0.68524247899289	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.53107237892739	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [179-338]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIAVRSRNTS STDSSPKLHT NLSQEYIGVS AGKSASDKED TWPDFVPIDR TVLEKIELNH  60
   61 TKVAGKVFVL EEICKNMKGT IEKLAEKSKI DVIDKEYMKR PKRKQYSKAL LTKQKMFHFR 120
  121 QNVLSHLTDE EFLSPINEMF TTTFKYSILQ TKLVLDFSFR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
nucleic acid binding	2.36440811505803	bayes_pls_golite062009
DNA binding	2.25848660128916	bayes_pls_golite062009
binding	2.23525969523197	bayes_pls_golite062009
transcription regulator activity	2.17762225700059	bayes_pls_golite062009
transcription factor activity	1.07713564675134	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.523017357555093	bayes_pls_golite062009
sequence-specific DNA binding	0.479128525355337	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.176810808981692	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [339-624]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SASSPSSDNI LYPLPRLAIA KRLLKNIKCP SLASLLHIVD VDQCLQFADV HFDPAKGRLT  60
   61 SSQAFLLNIC LCLGATVTNF EEKQELVDED NHETYYFEKF ELWRLRSFTF LNSVYYYHKL 120
  121 SVARADMTAL KALLLLAKFA QQKISASSAV KVLSVAIKVA LDLRLNLHST YEDLELDEII 180
  181 KRRRLWCYCF STDKFFSVVL SRPPFLKEEN TDVLTDESYV ELFRDKILPN LSIKYDDSKL 240
  241 EGVKDIVSVV NLLANHLEYV PYIQSYFLSR LSLIESQIYY SCFSIR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [625-915]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTLDDTLDEI IENVLENQKA LDRMRDDLPT ILSLENYKEN MRILSLDSSK LDFEVSCCTT  60
   61 ILLHLRWYHQ KITLSLFVIS IIGDNLDQRE SSRHDIAEII RRSRLDFKRN CIEVLNILKD 120
  121 FEYYPTVQNE FLYFSLTTVF SMFLYLSEIM VNDEHAMETG YIIGLLRDTH TRMLGSEERC 180
  181 LSVHNLKWQT SLFFYTFFLR STMEKFNLTS KYAKFYAFDS NYYEGVLNRL VKHTRESKDD 240
  241 MVELLKTSFI NKEKMAAFGS FVTEDQEKME VSFNIFNEIT IQDLNFLQFS S

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [916-975]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPKLWENKTL EPGEEYHHSN GTNTDNNETT GADDTDDNNN NNNNNNKNGN NSSSTINNNN  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.16
Match:	1l8mA
Description:	No description for 1l8mA was found.

Predicted Domain #7

Region A:
Residues: [976-1094]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNYSNSNNND NDNNINDDDD DDDDDDDDDD DDDDDDDNDD DYSNNGADDD EEDDDYDRSL  60
   61 FPTGLASLLD ASYPERTAND YRDENEQSNK LFEKIEGHLE HGVFFYDRDF FFKNVCVKM

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.16
Match:	1l8mA
Description:	No description for 1l8mA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: