| Protein: | MEC1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 2368 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MEC1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [461..2367] | [710..2643] |
|
|
0.0 | [522..2368] | [534..2386] |
|
|
0.0 | [698..2367] | [1226..3065] |
|
|
0.0 | [1..2368] | [1..2368] |
|
|
0.0 | [820..2367] | [1..1707] |
|
|
0.0 | [462..2368] | [520..2454] |
|
|
0.0 | [480..2368] | [701..2702] |
|
|
0.0 | [618..2367] | [875..2653] |
|
Region A: Residues: [1-555] |
1 11 21 31 41 51
| | | | | |
1 MESHVKYLDE LILAIKDLNS GVDSKVQIKK VPTDPSSSQE YAKSLKILNT LIRNLKDQRR 60
61 NNIMKNDTIF SKTVSALALL LEYNPFLLVM KDSNGNFEIQ RLIDDFLNIS VLNYDNYHRI 120
121 WFMRRKLGSW CKACVEFYGK PAKFQLTAHF ENTMNLYEQA LTEVLLGKTE LLKFYDTLKG 180
181 LYILLYWFTS EYSTFGNSIA FLDSSLGFTK FDFNFQRLIR IVLYVFDSCE LAALEYAEIQ 240
241 LKYISLVVDY VCNRTISTAL DAPALVCCEQ LKFVLTTMHH FLDNKYGLLD NDPTMAKGIL 300
301 RLYSLCISND FSKCFVDHFP IDQWADFSQS EHFPFTQLTN KALSIVYFDL KRRSLPVEAL 360
361 KYDNKFNIWV YQSEPDSSLK NVTSPFDDRY KQLEKLRLLV LKKFNKTERG TLLKYRVNQL 420
421 SPGFFQRAGN DFKLILNEAS VSIQTCFKTN NITRLTSWTV ILGRLACLES EKFSGTLPNS 480
481 TKDMDNWYVC HLCDIEKTGN PFVRINPNRP EAAGKSEIFR ILHSNFLSHP NIDEFSESLL 540
541 SGILFSLHRI FSHFQ
|
| Detection Method: |  |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [556-974] |
1 11 21 31 41 51
| | | | | |
1 PPKLTDGNGQ INKSFKLVQK CFMNSNRYLR LLSTRIIPLF NISDSHNSED EHTATLIKFL 60
61 QSQKLPVVKE NLVIAWTQLT LTTSNDVFDT LLLKLIDIFN SDDYSLRIMM TLQIKNMAKI 120
121 LKKTPYQLLS PILPVLLRQL GKNLVERKVG FQNLIELLGY SSKTILDIFQ RYIIPYAIIQ 180
181 YKSDVLSEIA KIMCDGDTSL INQMKVNLLK KNSRQIFAVA LVKHGLFSLD ILETLFLNRA 240
241 PTFDKGYITA YLPDYKTLAE ITKLYKNSVT KDASDSENAN MILCSLRFLI TNFEKDKRHG 300
301 SKYKNINNWT DDQEQAFQKK LQDNILGIFQ VFSSDIHDVE GRTTYYEKLR VINGISFLII 360
361 YAPKKSIISA LAQISICLQT GLGLKEVRYE AFRCWHLLVR HLNDEELSTV IDSLIAFIL
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [975-1241] |
1 11 21 31 41 51
| | | | | |
1 QKWSEFNGKL RNIVYSILDT LIKEKSDLIL KLKPYTTLAL VGKPELGILA RDGQFARMVN 60
61 KIRSTTDLIP IFANNLKSSN KYVINQNLDD IEVYLRRKQT ERSIDFTPKK VGQTSDITLV 120
121 LGALLDTSHK FRNLDKDLCE KCAKCISMIG VLDVTKHEFK RTTYSENEVY DLNDSVQTIK 180
181 FLIWVINDIL VPAFWQSENP SKQLFVALVI QESLKYCGLS SESWDMNHKE LYPNEAKLWE 240
241 KFNSVSKTTI YPLLSSLYLA QSWKEYV
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [1242-1376] |
1 11 21 31 41 51
| | | | | |
1 PLKYPSNNFK EGYKIWVKRF TLDLLKTGTT ENHPLHVFSS LIREDDGSLS NFLLPYISLD 60
61 IIIKAEKGTP YADILNGIII EFDSIFTCNL EGMNNLQVDS LRMCYESIFR VFEYCKKWAT 120
121 EFKQNYSKLH GTFII
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.834 | 0.233 | DNA damage checkpoint | a.25.1 | Ferritin-like |
| View | Download | 0.730 | 0.041 | DNA damage checkpoint | f.13.1 | Family A G protein-coupled receptor-like |
| View | Download | 0.751 | 0.017 | protein kinase activity | a.29.5 | alpha-ketoacid dehydrogenase kinase, N-terminal domain |
| View | Download | 0.820 | 0.013 | DNA damage checkpoint | a.63.1 | Apolipophorin-III |
| View | Download | 0.647 | N/A | N/A | a.8.3 | Families 57/38 glycoside transferase middle domain |
| View | Download | 0.645 | N/A | N/A | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.614 | N/A | N/A | a.24.11 | Bacterial GAP domain |
| View | Download | 0.605 | N/A | N/A | a.24.14 | FAT domain of focal adhesion kinase |
| View | Download | 0.568 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.554 | N/A | N/A | a.46.1 | Methionine synthase domain |
| View | Download | 0.547 | N/A | N/A | a.7.1 | Spectrin repeat |
| View | Download | 0.529 | N/A | N/A | f.31.1 | Photosystem I reaction center subunit XI, PsaL |
| View | Download | 0.473 | N/A | N/A | f.36.1 | Neurotransmitter-gated ion-channel pransmembrane pore |
| View | Download | 0.466 | N/A | N/A | a.7.3 | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain |
| View | Download | 0.438 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.436 | N/A | N/A | f.32.1 | a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) |
| View | Download | 0.435 | N/A | N/A | f.1.4 | Bcl-2 inhibitors of programmed cell death |
| View | Download | 0.435 | N/A | N/A | f.13.1 | Family A G protein-coupled receptor-like |
| View | Download | 0.430 | N/A | N/A | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.428 | N/A | N/A | a.8.2 | Plasmid maintenance system epsilon/zeta, antidote epsilon subunit |
| View | Download | 0.428 | N/A | N/A | a.24.4 | Hemerythrin |
| View | Download | 0.425 | N/A | N/A | f.14.1 | Voltage-gated potassium channels |
| View | Download | 0.424 | N/A | N/A | c.23.5 | Flavoproteins |
| View | Download | 0.420 | N/A | N/A | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.403 | N/A | N/A | f.36.1 | Neurotransmitter-gated ion-channel pransmembrane pore |
| View | Download | 0.400 | N/A | N/A | a.47.2 | t-snare proteins |
| View | Download | 0.395 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.386 | N/A | N/A | a.25.1 | Ferritin-like |
| View | Download | 0.377 | N/A | N/A | a.118.8 | TPR-like |
| View | Download | 0.365 | N/A | N/A | a.69.1 | C-terminal domain of alpha and beta subunits of F1 ATP synthase |
| View | Download | 0.358 | N/A | N/A | a.29.2 | Bromodomain |
| View | Download | 0.352 | N/A | N/A | d.8.1 | Urease, gamma-subunit |
| View | Download | 0.351 | N/A | N/A | a.73.1 | Retrovirus capsid protein, N-terminal core domain |
| View | Download | 0.349 | N/A | N/A | f.1.4 | Bcl-2 inhibitors of programmed cell death |
| View | Download | 0.346 | N/A | N/A | a.24.11 | Bacterial GAP domain |
| View | Download | 0.341 | N/A | N/A | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.336 | N/A | N/A | f.14.1 | Voltage-gated potassium channels |
| View | Download | 0.331 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.330 | N/A | N/A | a.118.9 | ENTH/VHS domain |
| View | Download | 0.325 | N/A | N/A | a.7.7 | BAG domain |
| View | Download | 0.303 | N/A | N/A | f.21.1 | Transmembrane di-heme cytochromes |
| View | Download | 0.299 | N/A | N/A | a.29.2 | Bromodomain |
| View | Download | 0.299 | N/A | N/A | a.2.3 | Chaperone J-domain |
| View | Download | 0.283 | N/A | N/A | a.2.11 | Fe,Mn superoxide dismutase (SOD), N-terminal domain |
| View | Download | 0.282 | N/A | N/A | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.277 | N/A | N/A | a.7.8 | GAT domain |
| View | Download | 0.277 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.272 | N/A | N/A | d.58.26 | GHMP Kinase, C-terminal domain |
| View | Download | 0.269 | N/A | N/A | a.7.4 | Smac/diablo |
| View | Download | 0.267 | N/A | N/A | a.118.13 | Arp2/3 complex 16 kDa subunit ARPC5 |
| View | Download | 0.266 | N/A | N/A | a.118.1 | ARM repeat |
| View | Download | 0.266 | N/A | N/A | a.78.1 | Fatty acid responsive transcription factor FadR, C-terminal domain |
| View | Download | 0.266 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.265 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.262 | N/A | N/A | i.11.1 | Computational models partly based on NMR data |
| View | Download | 0.251 | N/A | N/A | a.7.3 | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain |
| View | Download | 0.250 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.249 | N/A | N/A | a.29.3 | Acyl-CoA dehydrogenase C-terminal domain-like |
| View | Download | 0.247 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.246 | N/A | N/A | a.7.7 | BAG domain |
| View | Download | 0.243 | N/A | N/A | a.29.4 | RecG, N-terminal domain |
| View | Download | 0.243 | N/A | N/A | a.133.1 | Phospholipase A2, PLA2 |
| View | Download | 0.242 | N/A | N/A | b.82.4 | Regulatory protein AraC |
| View | Download | 0.239 | N/A | N/A | c.44.1 | Phosphotyrosine protein phosphatases I |
| View | Download | 0.238 | N/A | N/A | a.118.11 | Cytochrome c oxidase subunit E |
| View | Download | 0.237 | N/A | N/A | a.29.3 | Acyl-CoA dehydrogenase C-terminal domain-like |
| View | Download | 0.236 | N/A | N/A | a.2.3 | Chaperone J-domain |
| View | Download | 0.234 | N/A | N/A | g.52.1 | Inhibitor of apoptosis (IAP) repeat |
| View | Download | 0.234 | N/A | N/A | d.87.2 | CO dehydrogenase flavoprotein C-terminal domain-like |
| View | Download | 0.232 | N/A | N/A | a.91.1 | Regulator of G-protein signalling, RGS |
| View | Download | 0.230 | N/A | N/A | a.133.1 | Phospholipase A2, PLA2 |
| View | Download | 0.221 | N/A | N/A | a.29.2 | Bromodomain |
| View | Download | 0.217 | N/A | N/A | a.118.9 | ENTH/VHS domain |
| View | Download | 0.217 | N/A | N/A | a.47.2 | t-snare proteins |
| View | Download | 0.216 | N/A | N/A | f.17.1 | F1F0 ATP synthase subunit C |
| View | Download | 0.214 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.210 | N/A | N/A | a.23.1 | HSC20 (HSCB), C-terminal oligomerisation domain |
| View | Download | 0.207 | N/A | N/A | a.2.7 | tRNA-binding arm |
| View | Download | 0.206 | N/A | N/A | a.24.2 | Aspartate receptor, ligand-binding domain |
| View | Download | 0.203 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| Term | Confidence | Notes |
| binding | 2.96084803796407 | bayes_pls_golite062009 |
| protein binding | 2.66176697577398 | bayes_pls_golite062009 |
| nucleic acid binding | 2.39117996950187 | bayes_pls_golite062009 |
| transcription regulator activity | 1.93307188158984 | bayes_pls_golite062009 |
| DNA binding | 1.77969838181048 | bayes_pls_golite062009 |
| protein transporter activity | 1.51072955431931 | bayes_pls_golite062009 |
| protein kinase activity | 1.40981221970766 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.19667256014399 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.18159704569055 | bayes_pls_golite062009 |
| kinase activity | 1.155617721412 | bayes_pls_golite062009 |
| transcription factor activity | 1.02508422532466 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.68280791022469 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.647706371567682 | bayes_pls_golite062009 |
| transferase activity | 0.567560860286018 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.19278880370842 | bayes_pls_golite062009 |
| hydrolase activity | 0.0962597719675237 | bayes_pls_golite062009 |
| clathrin binding | 0.0923079381755934 | bayes_pls_golite062009 |
| transcription activator activity | 0.061709024440191 | bayes_pls_golite062009 |
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Region A: Residues: [1377-1817] |
1 11 21 31 41 51
| | | | | |
1 KDTKTTNMLL RIDEFLRTTP SDLLAQRSLE TDSFERSALY LEQCYRQNPH DKNQNGQLLK 60
61 NLQITYEEIG DIDSLDGVLR TFATGNLVSK IEELQYSENW KLAQDCFNVL GKFSDDPKTT 120
121 TRMLKSMYDH QLYSQIISNS SFHSSDGKIS LSPDVKEWYS IGLEAANLEG NVQTLKNWVE 180
181 QIESLRNIDD REVLLQYNIA KALIAISNED PLRTQKYIHN SFRLIGTNFI TSSKETTLLK 240
241 KQNLLMKLHS LYDLSFLSSA KDKFEYKSNT TILDYRMERI GADFVPNHYI LSMRKSFDQL 300
301 KMNEQADADL GKTFFTLAQL ARNNARLDIA SESLMHCLER RLPQAELEFA EILWKQGEND 360
361 RALKIVQEIH EKYQENSSVN ARDRAAVLLK FTEWLDLSNN SASEQIIKQY QDIFQIDSKW 420
421 DKPYYSIGLY YSRLLERKKA E
|
| Detection Method: | |
| Confidence: | 68.026872 |
| Match: | PF02259 |
| Description: | FAT domain |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [1818-1972] |
1 11 21 31 41 51
| | | | | |
1 GYITNGRFEY RAISYFLLAF EKNTAKVREN LPKVITFWLD IAAASISEAP GNRKEMLSKA 60
61 TEDICSHVEE ALQHCPTYIW YFVLTQLLSR LLHSHQSSAQ IIMHILLSLA VEYPSHILWY 120
121 ITALVNSNSS KRVLRGKHIL EKYRQHSQNP HDLVS
|
| Detection Method: | |
| Confidence: | 166.9897 |
| Match: | 1e8yA_ |
| Description: | Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [1973-2133] |
1 11 21 31 41 51
| | | | | |
1 SALDLTKALT RVCLQDVKSI TSRSGKSLEK DFKFDMNVAP SAMVVPVRKN LDIISPLESN 60
61 SMRGYQPFRP VVSIIRFGSS YKVFSSLKKP KQLNIIGSDG NIYGIMCKKE DVRQDNQYMQ 120
121 FATTMDFLLS KDIASRKRSL GINIYSVLSL REDCGILEMV P
|
|
Region B: Residues: [2294-2322] |
1 11 21 31 41 51
| | | | | |
1 KNEVALMNVI ETIMYDRNMD HSIQKALKV
|
| Detection Method: | |
| Confidence: | 166.9897 |
| Match: | 1e8yA_ |
| Description: | Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [2134-2293] |
1 11 21 31 41 51
| | | | | |
1 NVVTLRSILS TKYESLKIKY SLKSLHDRWQ HTAVDGKLEF YMEQVDKFPP ILYQWFLENF 60
61 PDPINWFNAR NTYARSYAVM AMVGHILGLG DRHCENILLD IQTGKVLHVD FDCLFEKGKR 120
121 LPVPEIVPFR LTPNLLDALG IIGTEGTFKK SSEVTLALMR
|
|
Region B: Residues: [2323-2368] |
1 11 21 31 41 51
| | | | | |
1 LRNKIRGIDP QDGLVLSVAG QTETLIQEAT SEDNLSKMYI GWLPFW
|
| Detection Method: | |
| Confidence: | 166.9897 |
| Match: | 1e8yA_ |
| Description: | Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [1644-1820] |
1 11 21 31 41 51
| | | | | |
1 SNTTILDYRM ERIGADFVPN HYILSMRKSF DQLKMNEQAD ADLGKTFFTL AQLARNNARL 60
61 DIASESLMHC LERRLPQAEL EFAEILWKQG ENDRALKIVQ EIHEKYQENS SVNARDRAAV 120
121 LLKFTEWLDL SNNSASEQII KQYQDIFQID SKWDKPYYSI GLYYSRLLER KKAEGYI
|
| Detection Method: | |
| Confidence: | 5.69897 |
| Match: | 2fo7A |
| Description: | Crystal structure of an 8 repeat consensus TPR superhelix (trigonal crystal form) |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [1821-2368] |
1 11 21 31 41 51
| | | | | |
1 TNGRFEYRAI SYFLLAFEKN TAKVRENLPK VITFWLDIAA ASISEAPGNR KEMLSKATED 60
61 ICSHVEEALQ HCPTYIWYFV LTQLLSRLLH SHQSSAQIIM HILLSLAVEY PSHILWYITA 120
121 LVNSNSSKRV LRGKHILEKY RQHSQNPHDL VSSALDLTKA LTRVCLQDVK SITSRSGKSL 180
181 EKDFKFDMNV APSAMVVPVR KNLDIISPLE SNSMRGYQPF RPVVSIIRFG SSYKVFSSLK 240
241 KPKQLNIIGS DGNIYGIMCK KEDVRQDNQY MQFATTMDFL LSKDIASRKR SLGINIYSVL 300
301 SLREDCGILE MVPNVVTLRS ILSTKYESLK IKYSLKSLHD RWQHTAVDGK LEFYMEQVDK 360
361 FPPILYQWFL ENFPDPINWF NARNTYARSY AVMAMVGHIL GLGDRHCENI LLDIQTGKVL 420
421 HVDFDCLFEK GKRLPVPEIV PFRLTPNLLD ALGIIGTEGT FKKSSEVTLA LMRKNEVALM 480
481 NVIETIMYDR NMDHSIQKAL KVLRNKIRGI DPQDGLVLSV AGQTETLIQE ATSEDNLSKM 540
541 YIGWLPFW
|
| Detection Method: | |
| Confidence: | 105.0 |
| Match: | 1e8yA |
| Description: | Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain |
| Matching Structure (courtesy of the PDB): |
|
