YRC Public Data Repository - Protein Structure Prediction

Protein:	GAL10
Organism:	Saccharomyces cerevisiae
Length:	699 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GAL10.

Description	E-value	Query Range	Subject Range
GAL10 - UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galacto... gi\|151946412 - gi\|151946412\|gb\|EDN64634.1\| UDP-glucose 4-epimerase [Saccharomyces cerevisiae YJM789] gi\|190408810 - gi\|190408810\|gb\|EDV12075.1\| UDP-glucose 4-epimerase [Saccharomyces cerevisiae RM11-1a] gi\|207347792 - gi\|207347792\|gb\|EDZ73858.1\| YBR019Cp-like protein [Saccharomyces cerevisiae AWRI1631] GAL10_YEAST - Bifunctional protein GAL10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GAL10 PE=1 SV...	0.0	[1..699]	[1..699]
GAL10_SCHPO - Bifunctional protein gal10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=gal10 PE=3 SV=1 SPBPB2B2.12c - UDP-glucose 4-epimerase	0.0	[14..696]	[8..688]
GAL10_KLULA - Bifunctional protein GAL10 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1... GAL10_KLULA, GAL... - (P09609) GAL10 bifunctional protein [Includes: UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenas...	0.0	[9..698]	[2..684]
GAL10_PACTA - Bifunctional protein GAL10 OS=Pachysolen tannophilus GN=GAL10 PE=2 SV=1	0.0	[14..698]	[4..686]
gi\|171565\|gb\|AAA... - gal10 gi\|171565 - gi\|171565\|gb\|AAA34629.1\| gal10	0.0	[305..699]	[4..398]
gi\|221325375 - gi\|221325375\|ref\|ZP_03606669.1\| UDP-glucose 4-epimerase [Bacillus subtilis subsp. subtilis str. SMY] gi\|221321091 - gi\|221321091\|ref\|ZP_03602385.1\| UDP-glucose 4-epimerase [Bacillus subtilis subsp. subtilis str. JH64... gi\|221316179 - gi\|221316179\|ref\|ZP_03597984.1\| UDP-glucose 4-epimerase [Bacillus subtilis subsp. subtilis str. NCIB... GALE_BACSU - UDP-glucose 4-epimerase OS=Bacillus subtilis (strain 168) GN=galE PE=3 SV=1 GALE_BACSU - UDP-glucose 4-epimerase OS=Bacillus subtilis GN=galE PE=3 SV=1	0.0	[12..359]	[1..339]
gi\|23501944, gi\|... - gi\|23501944\|ref\|NP_698071.1\| UDP-glucose 4-epimerase [Brucella suis 1330], gi\|23347889\|gb\|AAN29986.1... gi\|254704356 - gi\|254704356\|ref\|ZP_05166184.1\| NAD-dependent epimerase/dehydratase [Brucella suis bv. 3 str. 686] gi\|2708270, gi\|8... - gi\|82616011\|emb\|CAJ11044.1\| NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epime... gi\|254697426 - gi\|254697426\|ref\|ZP_05159254.1\| NAD-dependent epimerase/dehydratase [Brucella abortus bv. 2 str. 86/... gi\|254730324 - gi\|254730324\|ref\|ZP_05188902.1\| NAD-dependent epimerase/dehydratase [Brucella abortus bv. 4 str. 292... gi\|161335827, gi... - gi\|161619016\|ref\|YP_001592903.1\| UDP-glucose 4-epimerase [Brucella canis ATCC 23365], gi\|161335827\|g... gi\|82699910 - gi\|82699910\|ref\|YP_414484.1\| NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epim... gi\|62289982, gi\|... - gi\|62289982\|ref\|YP_221775.1\| GalE-1, UDP-glucose 4-epimerase [Brucella abortus bv. 1 str. 9-941], gi... gi\|189024224, gi... - gi\|189024224\|ref\|YP_001934992.1\| NAD-dependent epimerase/dehydratase [Brucella abortus S19], gi\|1890... gi\|237815486, gi... - gi\|237815486\|ref\|ZP_04594484.1\| UDP-glucose 4-epimerase [Brucella abortus str. 2308 A], gi\|237790323... gi\|163843333, gi... - gi\|163843333\|ref\|YP_001627737.1\| UDP-glucose 4-epimerase [Brucella suis ATCC 23445], gi\|163674056\|gb...	0.0	[12..356]	[1..335]
gi\|225852568, gi... - gi\|225852568\|ref\|YP_002732801.1\| UDP-glucose 4-epimerase [Brucella melitensis ATCC 23457], gi\|225640... gi\|25292379 - pir\|\|AC3367 UDPglucose 4-epimerase (EC 5.1.3.2) [imported] - Brucella melitensis (strain 16M) gi\|17987204, gi\|... - gi\|17987204\|ref\|NP_539838.1\| UDP-glucose 4-epimerase [Brucella melitensis 16M], gi\|17982874\|gb\|AAL52...	0.0	[12..356]	[1..335]
UGE5_ARATH - UDP-glucose 4-epimerase 5 OS=Arabidopsis thaliana GN=UGE5 PE=1 SV=3	0.0	[11..362]	[3..349]

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Predicted Domain #1

Region A:
Residues: [1-137]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAQLQSEST SKIVLVTGGA GYIGSHTVVE LIENGYDCVV ADNLSNSTYD SVARLEVLTK  60
   61 HHIPFYEVDL CDRKGLEKVF KEYKIDSVIH FAGLKAVGES TQIPLRYYHN NILGTVVLLE 120
  121 LMQQYNVSKF VFSSSAT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [158-191]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPTNPYGHTK YAIENILNDL YNSDKKSWKF AILR

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [254-278]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAKGHIAALQ YLEAYNENEG LCREW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1160.0
Match:	1hzjA_
Description:	Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aldose 1-epimerase activity	2.85100059704396	bayes_pls_golite062009
UDP-glucose 4-epimerase activity	2.13934644118967	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.03956654822048	bayes_pls_golite062009
nucleic acid binding	0.868888700854563	bayes_pls_golite062009
binding	0.835119783772935	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.82673050487418	bayes_pls_golite062009
DNA binding	0.790382977752475	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	0.65743456407889	bayes_pls_golite062009
transcription regulator activity	0.613310508772122	bayes_pls_golite062009
retinol dehydrogenase activity	0.48941662111046	bayes_pls_golite062009
NAD or NADH binding	0.44922383360529	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
transcription factor activity	0.11102650759187	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	0.0498966688564807	bayes_pls_golite062009

Predicted Domain #2

Region A: Residues: [138-157]	1 11 21 31 41 51 \| \| \| \| \| \| 1 VYGDATRFPN MIPIPEECPL [Run NCBI BLAST on this sequence.]
Region B: Residues: [192-196]	1 11 21 31 41 51 \| \| \| \| \| \| 1 YFNPI [Run NCBI BLAST on this sequence.]
Region C: Residues: [247-253]	1 11 21 31 41 51 \| \| \| \| \| \| 1 DYIHVVD [Run NCBI BLAST on this sequence.]
Region D: Residues: [279-285]	1 11 21 31 41 51 \| \| \| \| \| \| 1 NLGSGKG [Run NCBI BLAST on this sequence.]
Region E: Residues: [314-335]	1 11 21 31 41 51 \| \| \| \| \| \| 1 DVLNLTAKPD RAKRELKWQT EL [Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1160.0
Match:	1hzjA_
Description:	Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [197-246]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAHPSGLIGE DPLGIPNNLL PYMAQVAVGR REKLYIFGDD YDSRDGTPIR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [286-313]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STVFEVYHAF CKASGIDLPY KVTGRRAG

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [336-366]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QVEDSCKDLW KWTTENPFGY QLRGVEARFS A

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1160.0
Match:	1hzjA_
Description:	Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase)
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [367-699]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDMRYDARFV TIGAGTRFQA TFANLGASIV DLKVNGQSVV LGYENEEGYL NPDSAYIGAT  60
   61 IGRYANRISK GKFSLCNKDY QLTVNNGVNA NHSSIGSFHR KRFLGPIIQN PSKDVFTAEY 120
  121 MLIDNEKDTE FPGDLLVTIQ YTVNVAQKSL EMVYKGKLTA GEATPINLTN HSYFNLNKPY 180
  181 GDTIEGTEIM VRSKKSVDVD KNMIPTGNIV DREIATFNST KPTVLGPKNP QFDCCFVVDE 240
  241 NAKPSQINTL NNELTLIVKA FHPDSNITLE VLSTEPTYQF YTGDFLSAGY EARQGFAIEP 300
  301 GRYIDAINQE NWKDCVTLKN GETYGSKIVY RFS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	244.67837
Match:	1l7jA_
Description:	Galactose mutarotase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: