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View Structure Prediction Details

Protein: HIR1
Organism: Saccharomyces cerevisiae
Length: 840 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIR1.

Description E-value Query
Range		 Subject
Range
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=...
gi|25530855 - pir||AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)
 0.0 [138..783] [865..1492]
HIR1 - Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene tra...
 0.0 [1..840] [1..840]
gi|17225210 - gi|17225210|gb|AAL37301.1|AF323585_1 beta transducin-like protein HET-D2Y [Podospora anserina]
 0.0 [9..576] [823..1341]

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Predicted Domain #1
Region A:
Residues: [1-77] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVVKFPWLA HREESRKYEI YTVDVSHDGK RLATGGLDGK IRIWSIDSIL RCMELESLTP  60
   61 EIPLPQDLQM PLCSMSR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 130.67837
Match: 1gg2B_
Description: beta1-subunit of the signal-transducing G protein heterotrimer
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [78-130] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HTGSITCVKF SPDGKYLASG SDDRILLIWA LDEEQSSQPA FGSEHEREHW TVR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 142.38764
Match: 1erjA_
Description: Tup1, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
6.67009948605948 bayes_pls_golite062009
snoRNA binding 4.78410616474982 bayes_pls_golite062009
RNA binding 3.77273677738815 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.79445416141967 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
transcription regulator activity 2.3610959773142 bayes_pls_golite062009
nucleic acid binding 2.30918780727915 bayes_pls_golite062009
transcription repressor activity 2.29049708962212 bayes_pls_golite062009
dynein binding 1.74989209255308 bayes_pls_golite062009
DNA binding 1.71685536470455 bayes_pls_golite062009
transcription corepressor activity 1.41752877005447 bayes_pls_golite062009
structural molecule activity 1.31060431370834 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
cytoskeletal protein binding 1.19593750149343 bayes_pls_golite062009
transcription factor activity 1.08768505897883 bayes_pls_golite062009
mRNA binding 1.05053985350578 bayes_pls_golite062009
histone binding 0.685319917508843 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.676924760416604 bayes_pls_golite062009
DNA-dependent ATPase activity 0.625780732991652 bayes_pls_golite062009
actin binding 0.529861581509437 bayes_pls_golite062009
transcription factor binding 0.489473003915035 bayes_pls_golite062009
transcription cofactor activity 0.30761651528651 bayes_pls_golite062009
DNA helicase activity 0.220747580531792 bayes_pls_golite062009
chromatin binding 0.151977098745772 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [131-535] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRLVAHDNDI QDICWAPDSS ILVTVGLDRS VIVWNGSTFE KLKRFDVHQS LVKGVVFDPA  60
   61 NKYFATTSDD RTMKIFRYHK TGDISFTIEH IITEPFKESP LTTYFRRPSW SPDGQHIAVP 120
  121 NATNGPVSSM AIVNRGTWDT NVSLIGHDAP TEVARFNPRL FERNAGVKQK KDDDPENALV 180
  181 GQNDDKVHHF DKNIDSVVAT AGQDKSLAVW STSRPRPILV AFDIANKSIT DMSWNPDGSL 240
  241 LFVASLDSSI TLFKFENNEL GKPIPLEKNM EQLYRYGVDK DSLDFPESIN QLLLEDQTKS 300
  301 FKHTKISTSK LGENHPTLAT NSASNQKDNN DASVSRSEHI NILIPKRKKD AILNKAVTLK 360
  361 SGKKRVAPTL ISTSSSSPFS NGIKKPTLDS KRIENNVKSS TKTIN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.221849
Match: 1k32A_
Description: Tricorn protease; Tricorn protease N-terminal domain; Tricorn protease domain 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
6.67009948605948 bayes_pls_golite062009
snoRNA binding 4.78410616474982 bayes_pls_golite062009
RNA binding 3.77273677738815 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.79445416141967 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
transcription regulator activity 2.3610959773142 bayes_pls_golite062009
nucleic acid binding 2.30918780727915 bayes_pls_golite062009
transcription repressor activity 2.29049708962212 bayes_pls_golite062009
dynein binding 1.74989209255308 bayes_pls_golite062009
DNA binding 1.71685536470455 bayes_pls_golite062009
transcription corepressor activity 1.41752877005447 bayes_pls_golite062009
structural molecule activity 1.31060431370834 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
cytoskeletal protein binding 1.19593750149343 bayes_pls_golite062009
transcription factor activity 1.08768505897883 bayes_pls_golite062009
mRNA binding 1.05053985350578 bayes_pls_golite062009
histone binding 0.685319917508843 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.676924760416604 bayes_pls_golite062009
DNA-dependent ATPase activity 0.625780732991652 bayes_pls_golite062009
actin binding 0.529861581509437 bayes_pls_golite062009
transcription factor binding 0.489473003915035 bayes_pls_golite062009
transcription cofactor activity 0.30761651528651 bayes_pls_golite062009
DNA helicase activity 0.220747580531792 bayes_pls_golite062009
chromatin binding 0.151977098745772 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [536-607] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKNTLLNVPE GVEKKISISS FPLPRLGIHS LIMGTKERSA WKISNSELEN DDADNAGGKG  60
   61 SDGTSNSIDD IA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.304 d.58.7 RNA-binding domain, RBD
View Download 0.253 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.309 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.259 a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.221 d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.214 g.3.7 Scorpion toxin-like
View Download 0.209 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.201 a.74.1 Cyclin-like

Predicted Domain #5
Region A:
Residues: [608-840] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLSEEENDFH RMTLNAKLTQ EKIWSEEPTT RCLLQSDVIP DTDVVVLEGG SLDDIAVLEI  60
   61 RNGVERSIQF DSEALLDNPT RILGYQGGKR TIETFIPEVI ICAIGSKDCK CWCLASANGS 120
  121 IYILSYNGQQ RIPKICLGHK VIKMVTSSKY LLVLTERGLF FAWDLLDLKL VLRNVPILPI 180
  181 LNGQPIHGNK VRINKVIKCF RLDGSSCDLL LEVGDPKNVY KWTKDLGCWS LYK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle