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View Structure Prediction Details

Protein: h0004690
Organism: SPECIES UNKNOWN
Length: 1303 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for h0004690.

Description E-value Query
Range		 Subject
Range
gi|10440468 - gi|10440468|dbj|BAB15767.1| FLJ00070 protein [Homo sapiens]
 0.0 [1..1303] [81..1382]
gi|114627589 - gi|114627589|ref|XP_520371.2| PREDICTED: notch1 isoform 2 [Pan troglodytes]
 0.0 [68..1300] [21..1187]
gi|31339070 - gi|31339070|dbj|BAC77039.1| transmembrane receptor Notch1 D [Mus musculus]
 0.0 [70..1300] [16..1182]
gi|73967531 - gi|73967531|ref|XP_537795.2| PREDICTED: similar to notch1 preproprotein [Canis familiaris]
 0.0 [96..1300] [18..1158]

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Predicted Domain #1
Region A:
Residues: [1-395] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGPRGAAGG LAPEMRGAGA AGLLALLLLL LLLLLGLGGR VEGGPAGERG AGGGGALARE  60
   61 RFKVVFAPVI CKRTCLKGQC RDSCQQGSNM TLIGENGHST DTLTGSGFRV VVCPLPCMNG 120
  121 GQCSSRNQCL CPPDFTGRFC QVPAGGAGGG TGGSGPGLSR TGALSTGALP PLAPEGDSVA 180
  181 SKHAIYAVQV IADPPGPGEG PPAQHAAFLV PLGPGQISAE VQAPPPVVNV RVHHPPEASV 240
  241 QVHRIESSNA ESAAPSQHLL PHPKPSHPRP PTQKPLGRCF QDTLPKQPCG SNPLPGLTKQ 300
  301 EDCCGSIGTA WGQSKCHKCP QLQYTGVQKP GPVRGEVGAD CPQGYKRLNS THCQDINECA 360
  361 MPGVCRHGDC LNNPGSYRCV CPPGHSLGPS RTQCI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.60755835611133 bayes_pls_golite062009
growth factor activity 4.38305031783896 bayes_pls_golite062009
extracellular matrix structural constituent 3.98005075037205 bayes_pls_golite062009
epidermal growth factor receptor binding 2.63546895705146 bayes_pls_golite062009
ErbB-2 class receptor binding 2.42443754640644 bayes_pls_golite062009
binding 2.33940742543305 bayes_pls_golite062009
protein binding 1.97546801934296 bayes_pls_golite062009
pattern binding 1.68711415550213 bayes_pls_golite062009
glycosaminoglycan binding 1.59362625477231 bayes_pls_golite062009
heparin binding 1.18377533277052 bayes_pls_golite062009
ErbB-3 class receptor binding 1.17748426017837 bayes_pls_golite062009
polysaccharide binding 0.907482471490999 bayes_pls_golite062009
transcription regulator activity 0.282532662545359 bayes_pls_golite062009
transcription factor binding 0.25804698792789 bayes_pls_golite062009
transcription cofactor activity 0.154111600670615 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [396-621] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADKPEEKSLC FRLVSPEHQC QHPLTTRLTR QLCCCSVGKA WGARCQRCPT DGTAAFKEIC  60
   61 PAGKGYHILT SHQTLTIQGE SDFSLFLHPD GPPKPQQLPE SPSQAPPPED TEEERGVTTD 120
  121 SPVSEERSVQ QSHPTATTTP ARPYPELISR PSPPTMRWFL PDLPPSRSAV EIAPTQVTET 180
  181 DECRLNQNIC GHGECVPGPP DYSCHCNPGY RSHPQHRYCV DVNECE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.08
Match: 1z1yA
Description: Crystal structure of Methylated Pvs25, an ookinete protein from Plasmodium vivax
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [622-734] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEPCGPGRGI CMNTGGSYNC HCNRGYRLHV GAGGRSCVDL NECAKPHLCG DGGFCINFPG  60
   61 HYKCNCYPGY RLKASRPPVC EDIDECRDPS SCPDGKCENK PGSFKCIACQ PGY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1lmjA
Description: Fibrillin-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.60755835611133 bayes_pls_golite062009
growth factor activity 4.38305031783896 bayes_pls_golite062009
extracellular matrix structural constituent 3.98005075037205 bayes_pls_golite062009
epidermal growth factor receptor binding 2.63546895705146 bayes_pls_golite062009
ErbB-2 class receptor binding 2.42443754640644 bayes_pls_golite062009
binding 2.33940742543305 bayes_pls_golite062009
protein binding 1.97546801934296 bayes_pls_golite062009
pattern binding 1.68711415550213 bayes_pls_golite062009
glycosaminoglycan binding 1.59362625477231 bayes_pls_golite062009
heparin binding 1.18377533277052 bayes_pls_golite062009
ErbB-3 class receptor binding 1.17748426017837 bayes_pls_golite062009
polysaccharide binding 0.907482471490999 bayes_pls_golite062009
transcription regulator activity 0.282532662545359 bayes_pls_golite062009
transcription factor binding 0.25804698792789 bayes_pls_golite062009
transcription cofactor activity 0.154111600670615 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [735-823] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSQGGGACRD VNECAEGSPC SPGWCENLPG SFRCTCAQGY APAPDGRSCL DVDECEAGDV  60
   61 CDNGICSNTP GSFQCQCLSG YHLSRDRSH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1emnA
Description: NMR STUDY OF A PAIR OF FIBRILLIN CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, MINIMIZED AVERAGE STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [824-1083] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CEDIDECDFP AACIGGDCIN TNGSYRCLCP QGHRLVGGRK CQDIDECSQD PSLCLPHGAC  60
   61 KNLQGSYVCV CDEGFTPTQD QHGCEEVEQP HHKKECYLNF DDTVFCDSVL ATNVTQQECC 120
  121 CSLGAGWGDH CEIYPCPVYS SAEFHSLCPD GKGYTQDNNI VNYGIPAHRD IDECMLFGSE 180
  181 ICKEGKCVNT QPGYECYCKQ GFYYDGNLLE CVDVDECLDE SNCRNGVCEN TRGGYRCACT 240
  241 PPAEYSPAQR QCLSPEEMDV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.29
Match: 1z1yA
Description: Crystal structure of Methylated Pvs25, an ookinete protein from Plasmodium vivax
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1084-1303] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DECQDPAACR PGRCVNLPGS YRCECRPPWV PGPSGRDCQL PESPAERAPE RRDVCWSQRG  60
   61 EDGMCAGPLA GPALTFDDCC CRQGRGWGAQ CRPCPPRGAG SHCPTSQSES NSFWDTSPLL 120
  121 LGKPPRDEDS SEEDSDECRC VSGRCVPRPG GAVCECPGGF QLDASRARCV DIDECRELNQ 180
  181 RGLLCKSERC VNTSGSFRCV CKAGFARSRP HGACVPQRRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1uzjA
Description: Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, holo form.
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle