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View Structure Prediction Details

Protein: gi|73971067
Organism: Canis lupus familiaris
Length: 346 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|73971067.

Description E-value Query
Range		 Subject
Range
gi|905387, gi|21... - gi|905387|gb|AAA70417.1| Hel-N2, pir||I39077 RNA-binding protein Hel-N2 - human
 3.0E-53 [1..346] [1..346]
gi|73971071 - gi|73971071|ref|XP_865082.1| PREDICTED: similar to ELAV-like 2 isoform 3 isoform 4 [Canis familiaris...
 7.0E-52 [1..346] [1..348]
gi|15020254 - gi|15020254|gb|AAK74152.1| ELAV-like neuronal protein-3 [Mus musculus]
 7.0E-52 [1..346] [1..348]
gi|109476919, gi... - gi|109476919|ref|XP_001063056.1| PREDICTED: similar to ELAV-like 4 isoform 5 [Rattus norvegicus], gi...
 9.0E-52 [1..346] [8..353]
gi|109004742 - gi|109004742|ref|XP_001110529.1| PREDICTED: similar to ELAV-like 4 isoform 2 [Macaca mulatta]
gi|114556480 - gi|114556480|ref|XP_001135194.1| PREDICTED: similar to RNA binding protein Elavl4 isoform 5 [Pan tro...
 1.0E-51 [1..346] [1..346]

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Predicted Domain #1
Region A:
Residues: [1-252] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METQLSNGPT CNNTANGPTT INNNCSSPVD SGNTEDSKTN LIVNYLPQNM TQEELKSLFG  60
   61 SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL NGLRLQTKTI KVSYARPSSA 120
  121 SIRDANLYVS GLPKTMTQKE LEQLFSQYGR IITSRILVDQ VTGISRGVGF IRFDKRIEAE 180
  181 EAIKGLNGQK PPGATEPITV KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRFS 240
  241 PMTIDGMTSL AG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.09691
Match: 1fnxH
Description: Hu antigen C (Huc)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.83802439076672 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
poly-pyrimidine tract binding 1.69629099229571 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
transcription repressor activity 1.06887262556449 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
mRNA 5'-UTR binding 0.625848256054783 bayes_pls_golite062009
translation repressor activity, nucleic acid binding 0.461000905454505 bayes_pls_golite062009
structure-specific DNA binding 0.43716526938634 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
snRNA binding 0.249682711188639 bayes_pls_golite062009
single-stranded DNA binding 0.2202184446161 bayes_pls_golite062009
structural molecule activity 0.166336846372115 bayes_pls_golite062009
translation regulator activity 0.117211881967154 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [253-346] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INIPGHPGTG WCIFVYNLAP DADESILWQM FGPFGAVTNV KVIRDFNTNK CKGFGFVTMT  60
   61 NYDEAAMAIA SLNGYRLGDR VLQVSFKTNK THKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.39794
Match: 1d8zA
Description: Hu antigen C (Huc)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.83802439076672 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
poly-pyrimidine tract binding 1.69629099229571 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
transcription repressor activity 1.06887262556449 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
mRNA 5'-UTR binding 0.625848256054783 bayes_pls_golite062009
translation repressor activity, nucleic acid binding 0.461000905454505 bayes_pls_golite062009
structure-specific DNA binding 0.43716526938634 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
snRNA binding 0.249682711188639 bayes_pls_golite062009
single-stranded DNA binding 0.2202184446161 bayes_pls_golite062009
structural molecule activity 0.166336846372115 bayes_pls_golite062009
translation regulator activity 0.117211881967154 bayes_pls_golite062009
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