YRC Public Data Repository - Protein Structure Prediction

Protein:	ADE_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	367 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADE_SCHPO.

Description	E-value	Query Range	Subject Range
ADE_HAHCH - Adenine deaminase OS=Hahella chejuensis (strain KCTC 2396) GN=HCH_01503 PE=3 SV=1	284.0	[0..6]	[349..1]
ADD2_VIBPA, ADE_... - Adenine deaminase OS=Vibrio parahaemolyticus GN=VPA1292 PE=3 SV=1, Adenosine deaminase 2 OS=Vibrio p... ADE_VIBPA - Adenine deaminase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=VPA1292 PE=3 SV...	282.0	[0..6]	[349..1]
ADD_CLOAB - Adenosine deaminase OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 /... ADD_CLOAB - Adenosine deaminase OS=Clostridium acetobutylicum GN=add PE=3 SV=1	281.0	[0..6]	[343..3]
ADE_CUPNH - Adenine deaminase OS=Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) GN=H16_A1...	281.0	[0..6]	[346..7]
ADE_PSYCK - Adenine deaminase OS=Psychrobacter cryohalolentis (strain K5) GN=Pcryo_0456 PE=3 SV=1	279.0	[0..6]	[345..1]
gi\|84379137, gi\|... - gi\|84385821\|ref\|ZP_00988851.1\| adenosine deaminase [Vibrio splendidus 12B01], gi\|84379137\|gb\|EAP9599...	279.0	[0..6]	[346..1]
ADE_WOLSU, ADD_WOLSU - Adenine deaminase OS=Wolinella succinogenes GN=WS0737 PE=3 SV=1, Adenosine deaminase OS=Wolinella su... ADE_WOLSU - Adenine deaminase OS=Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / ...	279.0	[0..6]	[342..4]
gi\|91190970, gi\|... - gi\|91224059\|ref\|ZP_01259322.1\| adenosine deaminase [Vibrio alginolyticus 12G01], gi\|91190970\|gb\|EAS7...	279.0	[0..6]	[351..1]
ADE_ACIAD - Adenine deaminase OS=Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) GN=ACIAD1245 PE=3 SV=1	278.0	[0..1]	[344..1]
gi\|90327787, gi\|... - gi\|90411258\|ref\|ZP_01219270.1\| adenosine deaminase [Photobacterium profundum 3TCK], gi\|90327787\|gb\|E...	277.0	[0..6]	[349..1]

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Predicted Domain #1

Region A:
Residues: [1-367]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNLPIYNFI RKLPKCEHHV HLEGCLSPDL VFRLAKKNGI TLPSDDAAYT TPSTLLASYE  60
   61 HFGCLDDFLR YYYIAVSVLI EASDFEALAY EYFSIAHSQG VHHAEVFFDP QTHTSRGISY 120
  121 DVVVSGFSAA CERANRDFGM STNLIMCFLR HLPSEAAHET FAEALKRNDF ENGIVAGVGL 180
  181 DSSEVDFPPE LFQEVYKLAA EKGIRRTGHA GEEGDPSYIR SGLDNLSLQR IDHGIRLVED 240
  241 KELMKRVAEE NIMLTMCPLS NLKLRCVNSI AELPVREFLE AGVPFSINCD DPAYFGGYTL 300
  301 ENYFAIQKHF NLTVKEWVFI ANAAINGSWI SGKRKEELLS SVQKCVKEYT AEIQQPKTLE 360
  361 TAVEVQA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.69897
Match:	2bgnE
Description:	HIV-1 Tat protein derived N-terminal nonapeptide Trp2-Tat(1-9) bound to the active site of Dipeptidyl peptidase IV (CD26)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
purine nucleoside binding	5.77008212157543	bayes_pls_golite062009
adenosine deaminase activity	4.58148305437166	bayes_pls_golite062009
adenine deaminase activity	3.70002828902508	bayes_pls_golite062009
hydrolase activity	3.62199995345412	bayes_pls_golite062009
dihydropyrimidinase activity	3.41635858763209	bayes_pls_golite062009
deaminase activity	1.79186203771221	bayes_pls_golite062009
catalytic activity	1.70199291046899	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.60895003474033	bayes_pls_golite062009
binding	1.20793368650496	bayes_pls_golite062009
protein binding	0.928500526896831	bayes_pls_golite062009
guanine deaminase activity	0.861706835095856	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	0.787370269329878	bayes_pls_golite062009
nucleic acid binding	0.629962267754185	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.573107361273483	bayes_pls_golite062009
transcription regulator activity	0.530552339840648	bayes_pls_golite062009
DNA binding	0.462348875991261	bayes_pls_golite062009
glycosaminoglycan binding	0.408989331337656	bayes_pls_golite062009
peptidase activity	0.356051335471361	bayes_pls_golite062009
dihydroorotase activity	0.203044795244555	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: