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View Structure Prediction Details

Protein: MCA1_SCHPO
Organism: Schizosaccharomyces pombe 972h-
Length: 425 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCA1_SCHPO.

Description E-value Query
Range		 Subject
Range
gi|66848051, gi|... - gi|70991140|ref|XP_750419.1| metacaspase, putative [Aspergillus fumigatus Af293], gi|66848051|gb|EAL...
 325.0 [0..74] [425..209]
MCA1B_NEUCR - Metacaspase-1B OS=Neurospora crassa GN=mca-2 PE=3 SV=1
MCA1B_NEUCR - Metacaspase-1B OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 9...
 305.0 [0..3] [417..9]
gi|27803045 - gi|27803045|emb|CAD60748.1| unnamed protein product [Podospora anserina]
 301.0 [0..85] [425..1]
MCA1_ASHGO - Metacaspase-1 OS=Ashbya gossypii GN=MCA1 PE=3 SV=1
MCA1_ASHGO - Metacaspase-1 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) GN=MCA1 ...
 290.0 [0..16] [425..47]
gi|116179586, gi... - gi|88184718|gb|EAQ92186.1| conserved hypothetical protein [Chaetomium globosum CBS 148.51], gi|11617...
 287.0 [0..88] [422..2]
MCA1_COCIM - Metacaspase-1 OS=Coccidioides immitis GN=MCA1 PE=3 SV=1
MCA1_COCIM - Metacaspase-1 OS=Coccidioides immitis (strain RS) GN=MCA1 PE=3 SV=1
 282.0 [0..7] [425..48]
gi|50310199, gi|... - gi|50310199|ref|XP_455119.1| unnamed protein product [Kluyveromyces lactis], gi|49644255|emb|CAG9782...
 281.0 [0..15] [425..46]
MCA1_USTMA - Metacaspase-1 OS=Ustilago maydis (strain 521 / FGSC 9021) GN=MCA1 PE=3 SV=1
MCA1_USTMA - Metacaspase-1 OS=Ustilago maydis GN=MCA1 PE=3 SV=1
 280.0 [0..13] [425..3]
gi|111057020 - gi|111057020|gb|EAT78140.1| hypothetical protein SNOG_14600 [Phaeosphaeria nodorum SN15]
 278.0 [0..2] [425..4]
MCA1B_ASPTN - Metacaspase-1B OS=Aspergillus terreus (strain NIH 2624 / FGSC A1156) GN=casB PE=3 SV=1
 276.0 [0..51] [425..3]

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Predicted Domain #1
Region A:
Residues: [1-140] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYNSNPYNG GQYPPYNTYT RPNYSPNNGS QSNNTVHQYQ PPRMPPPSTR PQTDGNSNQI  60
   61 PMENVGHISL SSANSHAYAP PSGPPPNTGA NSYGNPNYSG PQLPNTQTQS YNLAGGGNFQ 120
  121 YQYSTCQGKR KALLIGINYL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.221849
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [141-425] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTQNELQGCI NDVMSMSQLL IQRYGYKQED MVIMTDTASN QRAIPTRQNM LDAMRWLVSD  60
   61 AQPNDALFFH YSGHGGQTKD LDGDEVDGYD ETIYPLDHQY AGQIIDDEMH EIMVKPLPAG 120
  121 CRLTALFDSC HSGGALDLPF TYSTKGVLKE PNMLKESGMD VLHAGLSYAS GDIMGAINNV 180
  181 KNIFTSATNG FNNNALQYSR QVKFSPADVI SLSGCKDNQT SADTSVNGFA TGALSYAFRE 240
  241 VVTQNPQLSY LQLLRGIRQV LSNKYSQLPQ LSCSHPLDMN LAMVL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.74
Match: 1jxqA
Description: Caspase-9
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.1899507591953 bayes_pls_golite062009
binding 2.22924561610124 bayes_pls_golite062009
hydrolase activity 2.12972595354571 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.11446327232186 bayes_pls_golite062009
endopeptidase activity 1.925193622235 bayes_pls_golite062009
cysteine-type peptidase activity 1.92343694153446 bayes_pls_golite062009
protein binding 1.52087463248142 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.35765607557567 bayes_pls_golite062009
catalytic activity 0.976874866811795 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle