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View Structure Prediction Details

Protein: sv-PG
Organism: Drosophila melanogaster
Length: 628 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sv-PG.

Description E-value Query
Range
Subject
Range
sv-PD - The gene shaven is referred to in FlyBase by the symbol Dmel\sv (CG11049, FBgn0005561). It is a prot...
448.0 [0..1] [609..1]

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Predicted Domain #1
Region A:
Residues: [1-161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIMDIQTST HHIHGLGTHE LQHRILHPHI LHSTQEETLN TSTGQLEHDS QHLQQHHLTH  60
   61 HQQQDVSPTL HNLQNTRTGD SLSTTINTNQ NQHGHQHLSG SNMYTSSQME DKSKANKYDE 120
  121 YSSRTLSNIS DANTTPSANN FITQSQGIEW ITAMNDIQNG A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [162-308]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDSHSSQGSI SGDGHGGVNQ LGGVFVNGRP LPDVVRQRIV ELAHNGVRPC DISRQLRVSH  60
   61 GCVSKILSRY YETGSFKAGV IGGSKPKVAT PPVVDAIANY KRENPTMFAW EIRDRLLAEA 120
  121 ICSQDNVPSV SSINRIVRNK AAEKAKH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.69897
Match: 1k78A
Description: Pax-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [309-382]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VHHHQQHHVS QSLGGGHIAT ESVDSSTGTI GEPQPPTSNS SANSVNTNVS ASASVHASIP  60
   61 TSGTDSVQVS VGHI

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.34
Match: 2es4D
Description: Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [383-496]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NANSNETTHI NSTAEQRTTG YSINGILGIQ HGHHSHNNNN NSSVNNNNNT ESSCKRKRIE  60
   61 AHDENHDTNI HSDNDDGKRQ RMSTYSGDQL YTNIWSGKWC IKDDHKLLAE LGNL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.154902
Match: 2cueA
Description: Solution structure of the homeobox domain of the human paired box protein Pax-6
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [497-628]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TASTGNCPAT YYEASNGFST TPISGSGATA SGNDTSMLYD SITTISQTQS SIYTPAIGPS  60
   61 IGTGSLTPLV PISMHEMKLS ANSIQEQTVP PFYTGCSSVV PGSDYAYNPA YTQYGGAYGS 120
  121 YGYGTGSGLI SN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle