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View Structure Prediction Details

Protein: sv-PF
Organism: Drosophila melanogaster
Length: 792 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sv-PF.

Description E-value Query
Range
Subject
Range
sv-PA - The gene shaven is referred to in FlyBase by the symbol Dmel\sv (CG11049, FBgn0005561). It is a prot...
508.0 [0..1] [773..1]

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Predicted Domain #1
Region A:
Residues: [1-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIMDIQTST HHIHGLGTHE LQHRILHPHI LHSTQEETLN TSTGQLEHDS QHLQQHHLTH  60
   61 HQQQDVSPTL HNLQNTRTGD SLSTTINTNQ NQHGHQHLSG SNMYTSSQME DKSKANKYDE 120
  121 YSSRTLSNIS DANTTPSANN FITQSQGIEW ITAMNDIQNG AEDSH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [166-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSQGSISGDG HGGVNQLGGV FVNGRPLPDV VRQRIVELAH NGVRPCDISR QLRVSHGCVS  60
   61 KILSRYYETG SFKAGVIGGS KPKVATPPVV DAIANYKREN PTMFAWEIRD RLLAEAICSQ 120
  121 DNVPSVSSIN RIVRNKAAEK A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.045757
Match: 1k78A
Description: Pax-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [307-507]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KHVHHHQQHH VSQSLGGGHI ATESVDSSTG TIGEPQPPTS NSSANSVNTN VSASASVHAS  60
   61 IPTSGTDSVQ VSVGHINANS NETTHINSTA EQRTTGYSIN GILGIQHGHH SHNNNNNSSV 120
  121 NNNNNTESSC KRKRIEAHDE NHDTNIHSDN DDGKRQRMST YSGDQLYTNI WSGKWCIKDD 180
  181 HKLLAELGNL TASTGNCPAT Y

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [508-583]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEASNGFSTT PISGSGATAS GNDTSMLYDS ITTISQTQSS IYTPAIGPSI GTGSLTPLVP  60
   61 ISMHEMKLSA NSIQEQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [584-792]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVPPFYTALA FDGNYTSMTS LENCSSLVGQ EHIVMPESSD SNTLCPISTR IVPDITETNS  60
   61 TRVKEPLTNS DGCSEDNNKE PEKSNSSQSS DHIASPHLHH IGEEQLRGNR RSNLNASTHP 120
  121 SSLIPLQPSG GSSLLNINPS ENRSDVELNL SNNVGLYSTP TVLPSFNHYS AGCSSVVPGS 180
  181 DYAYNPAYTQ YGGAYGSYGY GTGSGLISN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle