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View Structure Prediction Details

Protein: PCBP1_BOVIN
Organism: Bos taurus
Length: 356 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PCBP1_BOVIN.

Description E-value Query
Range		 Subject
Range
gi|5453854, gi|4... - gi|5453854|ref|NP_006187.1| poly(rC) binding protein 1 [Homo sapiens], gi|460771|emb|CAA55016.1| hnR...
 2.0E-73 [1..356] [1..356]
gi|57093423 - gi|57093423|ref|XP_538537.1| PREDICTED: similar to Poly(rC)-binding protein 1 (Alpha-CP1) (hnRNP-E1)...
 2.0E-73 [1..356] [1..356]
gi|109065037 - gi|109065037|ref|XP_001099433.1| PREDICTED: similar to poly(rC) binding protein 3 isoform 3 [Macaca ...
gi|114684791 - gi|114684791|ref|XP_001157797.1| PREDICTED: hypothetical protein isoform 6 [Pan troglodytes]
 1.0E-65 [1..354] [33..391]
gi|114577926 - gi|114577926|ref|XP_001140593.1| PREDICTED: poly(rC) binding protein 1 isoform 2 [Pan troglodytes]
 2.0E-65 [1..356] [1..333]
PCBP2 - poly(rC) binding protein 2
gi|61557337, gi|... - gi|61557337|ref|NP_001013241.1| poly(rC) binding protein 2 [Rattus norvegicus], gi|50926841|gb|AAH78...
 3.0E-64 [1..353] [1..361]

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Predicted Domain #1
Region A:
Residues: [1-89] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAGVTESGL NVTLTIRLLM HGKEVGSIIG KKGESVKRIR EESGARINIS EGNCPERIIT  60
   61 LTGPTNAIFK AFAMIIDKLE EDINSSMTN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.69897
Match: 2axyA
Description: Crystal Structure of KH1 domain of human Poly(C)-binding protein-2 with C-rich strand of human telomeric DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.18414740305744 bayes_pls_golite062009
nucleic acid binding 4.78650555542715 bayes_pls_golite062009
mRNA binding 3.82977088614136 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
transcription regulator activity 2.28364833275102 bayes_pls_golite062009
DNA binding 2.03207983673692 bayes_pls_golite062009
transcription factor activity 1.30278154718684 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
1.02980840568405 bayes_pls_golite062009
poly-pyrimidine tract binding 0.63404501189528 bayes_pls_golite062009
mRNA 3'-UTR binding 0.489176583045793 bayes_pls_golite062009
transcription repressor activity 0.392035003865213 bayes_pls_golite062009
transcription activator activity 0.324382863054631 bayes_pls_golite062009
transcription factor binding 0.254024117548226 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
sequence-specific DNA binding 0.0321875054165348 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [90-183] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STAASRPPVT LRLVVPATQC GSLIGKGGCK IKEIRESTGA QVQVAGDMLP NSTERAITIA  60
   61 GVPQSVTECV KQICLVMLET LSQSPQGRVM TIPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.0
Match: 1x4mA
Description: Solution structure of KH domain in Far upstream element binding protein 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.18414740305744 bayes_pls_golite062009
nucleic acid binding 4.78650555542715 bayes_pls_golite062009
mRNA binding 3.82977088614136 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
transcription regulator activity 2.28364833275102 bayes_pls_golite062009
DNA binding 2.03207983673692 bayes_pls_golite062009
transcription factor activity 1.30278154718684 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
1.02980840568405 bayes_pls_golite062009
poly-pyrimidine tract binding 0.63404501189528 bayes_pls_golite062009
mRNA 3'-UTR binding 0.489176583045793 bayes_pls_golite062009
transcription repressor activity 0.392035003865213 bayes_pls_golite062009
transcription activator activity 0.324382863054631 bayes_pls_golite062009
transcription factor binding 0.254024117548226 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
sequence-specific DNA binding 0.0321875054165348 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [184-269] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPMPASSPVI CAGGQDRCSD AAGYPHATHD LEGPPLDAYS IQGQHTISPL DLAKLNQVAR  60
   61 QQSHFAMMHG GTGFAGIDSS SPEVKG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [270-356] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YWASLDASTQ TTHELTIPNN LIGCIIGRQG ANINEIRQMS GAQIKIANPV EGSSGRQVTI  60
   61 TGSAASISLA QYLINARLSS EKGMGCS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.522879
Match: 1wvnA
Description: Crsytal Structure of domain 3 of human alpha polyC binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.18414740305744 bayes_pls_golite062009
nucleic acid binding 4.78650555542715 bayes_pls_golite062009
mRNA binding 3.82977088614136 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
transcription regulator activity 2.28364833275102 bayes_pls_golite062009
DNA binding 2.03207983673692 bayes_pls_golite062009
transcription factor activity 1.30278154718684 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
1.02980840568405 bayes_pls_golite062009
poly-pyrimidine tract binding 0.63404501189528 bayes_pls_golite062009
mRNA 3'-UTR binding 0.489176583045793 bayes_pls_golite062009
transcription repressor activity 0.392035003865213 bayes_pls_golite062009
transcription activator activity 0.324382863054631 bayes_pls_golite062009
transcription factor binding 0.254024117548226 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
sequence-specific DNA binding 0.0321875054165348 bayes_pls_golite062009
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