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View Structure Prediction Details

Protein: Hsf-PD
Organism: Drosophila melanogaster
Length: 733 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Hsf-PD.

Description E-value Query
Range
Subject
Range
Hsf-PB - The gene Heat shock factor is referred to in FlyBase by the symbol Dmel\Hsf (CG5748, FBgn0001222). I...
583.0 [0..1] [733..1]

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Predicted Domain #1
Region A:
Residues: [1-154]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRSRSSAKA VQFKHESEEE EEDEEEQLPS RRMHSYGDAA AIGSGVPAFL AKLWRLVDDA  60
   61 DTNRLICWTK DGQSFVIQNQ AQFAKELLPL NYKHNNMASF IRQLNMYGFH KITSIDNGGL 120
  121 RFDRDEIEFS HPFFKRNSPF LLDQIKRKIS NNKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.30103
Match: 1hksA
Description: SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription activator activity 3.70589483230587 bayes_pls_golite062009
sequence-specific DNA binding 3.58179858678904 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
protein binding 1.80415286835431 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.23177057841536 bayes_pls_golite062009
structural molecule activity 0.111941063082739 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [155-248]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDDKGVLKPE AMSKILTDVK VMRGRQDNLD SRFSAMKQEN EVLWREIASL RQKHAKQQQI  60
   61 VNKLIQFLIT IVQPSRNMSG VKRHVQLMIN NTPE

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 10.102373
Match: PF00447.8
Description: No description for PF00447.8 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [249-381]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDRARTTSET ESESGGGPVI HELREELLDE VMNPSPAGYT AASHYDQESV SPPAVERPRS  60
   61 NMSISSHNVD YSNQSVEDLL LQGNGTAGGN ILVGGAASPM AQSVSQSPAQ HDVYTVTEAP 120
  121 DSHVQEVPNS PPY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [382-477]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEEQNVLTTP MVREQEQQKR QQLKENNKLR RQAGDVILDA GDILVDSSSP KAQRTSIQHS  60
   61 TQPDVMVQPM IIKSEPENSS GLMDLMTPAN DLYSVN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [478-602]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FISEDMPTDI FEDALLPDGV EEAAKLDQQQ KFGQSTVSSG KFASNFDVPT NSTLLDANQA  60
   61 STSKAAAKAQ ASEEEGMAVA KYSGAENGNN RDTNNSQLLR MASVLVDQKN TNSSRISHNQ 120
  121 AANSY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [603-733]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CCSDELHGHL ESMQDELETL KDLLRGDGVA IDQNMLMGAL SRTPNFQLPE DELLLKLFND  60
   61 SDLMDNYGLS FPNDSISSEK KAPSGSELIS YQPMYDLSDI LDTDDGNNDQ EASRRQMQTQ 120
  121 SSVLNTPRHE L

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle