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View Structure Prediction Details

Protein: gi|77550896
Organism: Oryza sativa Japonica Group
Length: 521 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|77550896.

Description E-value Query
Range
Subject
Range
DRTS_MAIZE - Bifunctional dihydrofolate reductase-thymidylate synthase OS=Zea mays GN=DRTS PE=2 SV=1
730.0 [0..1] [521..1]

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Predicted Domain #1
Region A:
Residues: [1-521]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATTLSNGVS QNGPQRNYQV VVAATRDMGI GKDGVLPWKL LGDLKFFKEL TVTTADPVKK  60
   61 NAVIMGRKTW ESLPLKARPL PGRLNIILTR SGSFEFATVE NVVICGSMNS ALELLSSTPY 120
  121 CLSIEKVFVI GGGQVLRESL NGPSCEAVHL TDIQSSIECD TFIPPIDLSV FQPWYSSLPV 180
  181 VESNIRHSFV TYVRVRKTMA ETHDSNGKES ANDGIKSDKF ETENFSFLPK LIFDRHEEYH 240
  241 YLNLVEDIIR SGAQKNDRTG TGTLSKFGCQ MRFNLRNSFP LLTTKKVFWR GVVEELLWFI 300
  301 SGSTSAKVLQ EKGIHIWDGN ASREYLDSVG LAHREEGDLG PVYGFQWRHF GAEYTDMHAD 360
  361 YTGKGFDQLM DVIDKIKNNP DDRRIILSAW NPSDLKKMAL PPCHMFAQFY VESGELSCQM 420
  421 YQRSADMGLG VPFNIASYSL LTYMIAHVCG LSPGEFVHVI GDAHVYRTHV RALEEQIQKL 480
  481 PKPFPVLKIN PLKKDIDSFV ASDFKLVGYD PHQKIEMKMA I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 171.0
Match: 1qzfA
Description: Crystal structure of DHFR-TS from Cryptosporidium hominis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
thymidylate synthase activity 6.6988475347328 bayes_pls_golite062009
5,10-methylenetetrahydrofolate-dependent methyltransferase activity 6.29181090719132 bayes_pls_golite062009
dihydrofolic acid binding 5.17709559620199 bayes_pls_golite062009
dihydrofolate reductase activity 4.66343252900911 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4.14137539326183 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors 3.88025481634404 bayes_pls_golite062009
methyltransferase activity 2.19378329702464 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 2.11989367906451 bayes_pls_golite062009
binding 1.89072001556053 bayes_pls_golite062009
catalytic activity 1.73427871128495 bayes_pls_golite062009
transferase activity 1.72626940963556 bayes_pls_golite062009
oxidoreductase activity 0.63757996555211 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle