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View Structure Prediction Details

Protein: nht-PB
Organism: Drosophila melanogaster
Length: 245 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nht-PB.

Description E-value Query
Range
Subject
Range
gi|54306294 - gi|54306294|gb|AAV33342.1| TAF4 [Drosophila melanogaster]
319.0 [0..1] [245..1]
gi|82996542, gi|... - gi|94405219|ref|XP_983292.1| PREDICTED: similar to Transcription initiation factor TFIID 105 kDa sub...
227.0 [0..48] [242..643]
TAF4 - TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
gi|189442831 - gi|189442831|gb|AAI67776.1| TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor...
226.0 [0..47] [242..871]

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Predicted Domain #1
Region A:
Residues: [1-140]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIISLEVPI QPYAGQLLII NDLILPDSGS QDASKAKVSI KKNQRASFFD RSSIYKKIMK  60
   61 HLSQGNQADD INISEQEWLL DSFLAALETY MKHVVKKTIE LCEHRTSYHL HNDERCVMKN 120
  121 DMRVTMMFLN DLEIADYGSS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.221849
Match: 1h3oA
Description: TAF(II)-135, (TAF(II)-130, hTAF4), histone fold domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 9.25279783093877 bayes_pls_golite062009
DNA binding 4.24625687315724 bayes_pls_golite062009
transcription regulator activity 4.08606081850613 bayes_pls_golite062009
transcription initiation factor activity 3.96621818094279 bayes_pls_golite062009
nucleic acid binding 3.93473976418251 bayes_pls_golite062009
binding 3.79827182235984 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.28941584139552 bayes_pls_golite062009
transcription factor activity 2.31114764804139 bayes_pls_golite062009
protein binding 1.2861218811362 bayes_pls_golite062009
transcription activator activity 1.25487495162413 bayes_pls_golite062009
transcription factor binding 1.15204005455906 bayes_pls_golite062009
transcription coactivator activity 1.1297723528047 bayes_pls_golite062009
nucleotidyltransferase activity 1.10331930589736 bayes_pls_golite062009
transcription cofactor activity 1.01502031330902 bayes_pls_golite062009
transcription repressor activity 0.72554769377984 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.0792897588268993 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [141-245]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDETGFYRKR RAENIDEERK VARLESVNDT ALLAISGRKR PGEQLAPESA PSGSKVAKLT  60
   61 GAPIQRACAP RFKHMNIRDV LQFMEEDRRY ARSNMLFEAY LKYKS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle