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View Structure Prediction Details

Protein: nht-PB
Organism: Drosophila melanogaster
Length: 245 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nht-PB.

Description E-value Query
Range
Subject
Range
gi|54306294 - gi|54306294|gb|AAV33342.1| TAF4 [Drosophila melanogaster]
319.0 [0..1] [245..1]
gi|82996542, gi|... - gi|94405219|ref|XP_983292.1| PREDICTED: similar to Transcription initiation factor TFIID 105 kDa sub...
227.0 [0..48] [242..643]
TAF4 - TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
gi|189442831 - gi|189442831|gb|AAI67776.1| TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor...
226.0 [0..47] [242..871]

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Predicted Domain #1
Region A:
Residues: [1-140]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIISLEVPI QPYAGQLLII NDLILPDSGS QDASKAKVSI KKNQRASFFD RSSIYKKIMK  60
   61 HLSQGNQADD INISEQEWLL DSFLAALETY MKHVVKKTIE LCEHRTSYHL HNDERCVMKN 120
  121 DMRVTMMFLN DLEIADYGSS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.221849
Match: 1h3oA
Description: TAF(II)-135, (TAF(II)-130, hTAF4), histone fold domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 9.25279783093877 bayes_pls_golite062009
DNA binding 4.24625687315724 bayes_pls_golite062009
transcription regulator activity 4.08606081850613 bayes_pls_golite062009
transcription initiation factor activity 3.96621818094279 bayes_pls_golite062009
nucleic acid binding 3.93473976418251 bayes_pls_golite062009
binding 3.79827182235984 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.28941584139552 bayes_pls_golite062009
transcription factor activity 2.31114764804139 bayes_pls_golite062009
protein binding 1.2861218811362 bayes_pls_golite062009
transcription activator activity 1.25487495162413 bayes_pls_golite062009
transcription factor binding 1.15204005455906 bayes_pls_golite062009
transcription coactivator activity 1.1297723528047 bayes_pls_golite062009
nucleotidyltransferase activity 1.10331930589736 bayes_pls_golite062009
transcription cofactor activity 1.01502031330902 bayes_pls_golite062009
transcription repressor activity 0.72554769377984 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.0792897588268993 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [141-245]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDETGFYRKR RAENIDEERK VARLESVNDT ALLAISGRKR PGEQLAPESA PSGSKVAKLT  60
   61 GAPIQRACAP RFKHMNIRDV LQFMEEDRRY ARSNMLFEAY LKYKS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.355 N/A N/A d.26.1 FKBP-like
View Download 0.206 N/A N/A c.55.3 Ribonuclease H-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle