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View Structure Prediction Details

Protein: nhr-154
Organism: Caenorhabditis elegans
Length: 469 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-154.

Description E-value Query
Range
Subject
Range
gi|5702091 - gi|5702091|gb|AAD47137.1|AF061181_1 green fluorescent protein-estrogen receptor alpha fusion [Mammal...
306.0 [0..4] [468..370]

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Predicted Domain #1
Region A:
Residues: [1-160]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTFEEFESP STSFNFQTFD RYQPDFKMID YSHQQATHEY HLPDQEVFQN QNEFSASPPD  60
   61 ISSPFADEKI YKSLPRNKCP SKCLVCRNPA IGYHYDVPSC NGCKTFFRRT IITGRKFTCA 120
  121 KQKKCMDGTE PVDMSKRLCR ACRFAKCVEV GMNPMAIQAE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.09691
Match: 2hanB
Description: No description for 2hanB was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription activator activity 2.9532663930699 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
sequence-specific DNA binding 2.72967350701574 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.55186574506963 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.40923942043513 bayes_pls_golite062009
nuclear hormone receptor binding 1.91348392022358 bayes_pls_golite062009
transcription repressor activity 1.88834375049208 bayes_pls_golite062009
hormone receptor binding 1.8288193687002 bayes_pls_golite062009
steroid hormone receptor binding 1.72196998170947 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
androgen receptor binding 1.48596869620742 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
steroid hormone receptor activity 1.28090460550476 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.26452462867497 bayes_pls_golite062009
transcription coactivator activity 0.61572149323953 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
structural constituent of ribosome 0.525229083081488 bayes_pls_golite062009
structural molecule activity 0.281585397269403 bayes_pls_golite062009
receptor activity 0.230063209127305 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [161-469]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKTDEGKVLR SEVLNQRESL GVVSSLIVTE EDLLSRMIEK LTFVESKVEP LHRSGMPPGY  60
   61 RDIRKLEEIL DSKPVLVVTD IPNLKFCPSP CANEKRPRRH FTNYVHTSYL ASLESSKMFE 120
  121 FSSQLDLESR ILLMKHATLI CSNMMNAFFS INEMKSDILR HPDGSMSGHM RKFDRENDVM 180
  181 TDHVKLIQKT LITFLNHKVD KIEYLLFKAI MLCNPAVPGL DSWNQEIIEK ERNQYVKALL 240
  241 NYCLLQHGKL QGPTRFATIL AMAPIIENQS KNQKDFHVYI KAKHFQKHKK MGTTFRKCIS 300
  301 CMFDQIMET

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.0
Match: 1z5xE
Description: hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone A
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
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